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Exp 11, 12, 13
Exp 11, 12, 13
Exp 11, 12, 13
AMINES
AMINES
R1 NH
NH2
R2
R3
R1 N
R2
PROPERTIES OF AMINES
urine-like odor
Polar
Basic
HINSBERG TEST
differentiating test for 10, 20 and 30 amines
Reagent: benzenesulfonyl chloride/NaOH
Cl
O
S
O
Soluble ppt
White ppt
Amine
10 or 20 Amine
benzenesulfonylchloride
No ppt
10 Amine
+NaOH (aq)
Insoluble ppt
20 Amine
30 Amine
ASPIRIN
O
OH
O
O
CH3
SYNTHESIS OF ASPIRIN
O
OH
OH
H3C
OH
H2SO4
CH3
O
CH3
H2O
O
OH
OH
+ H3C
OH
H2SO4
OH
O
CH3
H2O
STARCH TEST
Role of starch in pharmaceutical preparation:
Excipient: diluent or binder
Reagent: I2
Formation of iodo-starch complex: bluishblack suspension
DEFINITION OF TERMS
Soap sodium salt of fatty acid
Fatty acid long chain carboxylic acid
Detergent sodium salt of long HC chain of
thioester
SYNTHESIS OF SOAP
+ NaOH
+ H2O
SYNTHESIS OF DETERGENT
NaCl
BASIS OF
COMPARISON
Structure
Activity in distilled
water
Activity in Hard
Water
Test for Glycerol
SOAP
DETERGENT
Formation of suds
Formation of suds
KHSO4
+ 2H2O
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