Scribd Logo
Upload

Welcome to Scribd!

  • Table 1 of IMFAR Presentation

    Uploaded by

    sbittker7334
    21 views1 page
    The document summarizes various biochemistry indicators associated with autism compared to controls. Many indicators found in autism subjects show methylation deficits, oxidative stress, dysbiosis, fatty acid and hormone abnormalities, neurotransmission irregularities, autoimmunity, and sulfation deficits. Specifically, subjects with autism commonly have lower levels of beneficial bacteria like bifidobacteria; higher levels of oxidative stress markers, ammonia, and harmful bacteria; and abnormalities in fatty acids, carnitine, hormones, neurotransmitters, antibodies, and sulfur metabolism.

    Original Description:

    Autism Biochemistry Part of Seth Bittker's IMFAR Presentation from 2015

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The document summarizes various biochemistry indicators associated with autism compared to controls. Many indicators found in autism subjects show methylation deficits, oxidative stress, dysbiosis, fatty acid and hormone abnormalities, neurotransmission irregularities, autoimmunity, and sulfation deficits. Specifically, subjects with autism commonly have lower levels of beneficial bacteria like bifidobacteria; higher levels of oxidative stress markers, ammonia, and harmful bacteria; and abnormalities in fatty acids, carnitine, hormones, neurotransmitters, antibodies, and sulfur metabolism.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    21 views1 page

    Table 1 of IMFAR Presentation

    Uploaded by

    sbittker7334
    The document summarizes various biochemistry indicators associated with autism compared to controls. Many indicators found in autism subjects show methylation deficits, oxidative stress, dysbiosis, fatty acid and hormone abnormalities, neurotransmission irregularities, autoimmunity, and sulfation deficits. Specifically, subjects with autism commonly have lower levels of beneficial bacteria like bifidobacteria; higher levels of oxidative stress markers, ammonia, and harmful bacteria; and abnormalities in fatty acids, carnitine, hormones, neurotransmitters, antibodies, and sulfur metabolism.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    of 1

    Table 1: Autism Biochemistry

    Methylation deficit

    Autoimmunity

    Excitory Amino As
    Disordered
    Neurotrans
    Hormonal
    Abmornalities

    sbittker@yahoo.com, Seth Bittker 2015


    p value

    67%

    Adams, 2011

    97

    0.002

    Lack of bifidobacteria

    84%

    West, 2014

    82

    0.0344

    Lack of bifidobacteria

    200%

    Adams, 2011

    82

    0.00002

    Ammonia in stool

    132%

    Wang, 2012

    54

    0.007

    8OHdG in blood

    900%

    87

    < 0.001

    Excess of lactobacilli
    Excess of ammonia producing
    microorganisms
    DNA damage from oxidative
    stress

    Catalase in blood

    412%

    Nitro-tyrosine in blood
    8-isoprostane in urine
    DHA in plasma
    GLA in plasma
    Oleic acid in plasma
    Total carnitine below mean
    Free carnitine below mean

    Dysbiosis

    Sulfation deficit

    Crucial

    Bifidobacteria in stool
    4-hydroxyphenyllactate in
    plasma
    Lactobacilli in stool

    Vascular damage

    Low

    Reference

    Indicator

    Fatty acid
    metabolism
    dysfunction

    High

    Autism relative
    to controls

    Characteristic

    Oxidative stress

    Key:

    Significance

    87

    <0.001

    225%
    147%
    50%
    23%
    19%
    166%
    166%

    GonzlezFraguela, 2013
    GonzlezFraguela, 2013
    Adams, 2011
    Ghezzo, 2013
    El-Ansary, 2011
    El-Ansary, 2011
    El-Ansary, 2011
    Filipek, 2004
    Filipek, 2004

    99
    41
    52
    52
    52
    100
    100

    < 0.0001
    <0.01
    na
    na
    na
    <0.001
    <0.001

    6-keto-PGF1 alpha in urine

    188%

    Yao, 2006

    38

    0.005

    2,3-dinor-TxB2 in urine
    Free sulfate in plasma
    Total sulfate in plasma
    Cystine in blood
    SAM in plasma

    161%
    35%
    72%
    91%
    94%

    Yao, 2006
    Adams, 2011
    Adams, 2011
    West, 2014
    Adams, 2011

    38
    99
    99
    82
    99

    0.01
    < 0.00001
    < 0.0001
    0.028
    < 0.0001

    Succinate in blood

    111%

    West, 2014

    82

    0.0457

    Total sulfate in urine


    Thiosulphate in urine
    Oxidized glutatione to
    reduced glutatione ratio

    225%
    704%

    Waring, 2000
    Waring, 2000

    300
    300

    <0.001
    <0.001

    149%

    Adams, 2011

    99

    < 0.0001

    Insufficient methylation

    SAM to SAH ratio in plasma

    90%

    Adams, 2011

    99

    0.006

    Insufficient methylation

    Anti-ds-DNA antibodies
    ANA antibodies
    Anti-phospholipid antibody
    levels
    Anti-cardiolipin antibody
    levels
    IL-6 cytokines levels
    Aspartate in blood

    850%
    1250%

    Mostafa, 2014
    Mostafa, 2014

    200
    200

    <0.001
    <0.001

    Antibodies to DNA
    Cell nucleus antibodies

    138%

    Carega, 2013

    87

    <0.01

    Cell membrane antibodies

    175%

    Carega, 2013

    87

    <0.001

    Mitochondrial antibodies

    172%

    Ashwood, 2011

    87

    0.008

    Elevation in inflammation

    133%

    West, 2014

    82

    <0.001

    High aspartate

    Glutamate in blood
    Serotonin in platelets
    Serotonin trans binding in
    midfrontal cortex
    Dopamine transport binding
    in brain
    DHEA sulfate
    Free testosterone
    acyl ghrelin

    128%
    131%

    West, 2014
    Mulder, 2004

    82
    121

    0.00144
    na

    44%

    Makkonen, 2008

    25

    0.001

    106%

    Makkonen, 2008

    25

    0.21

    255%
    339%
    71%

    West, 2014
    Al-Zaid, 2014
    Al-Zaid, 2014

    82
    59
    59

    0.00152
    0.001
    0.001

    High glutamate
    High serotonin in platelets
    Low serotonergic activity in
    midfrontal contex
    High dopaminageric activity in
    brain
    Excessive DHEA
    Excessive free testosterone
    Decreased ghrelin

    Antioxidant enzyme activated


    Free radical oxidation
    Peroxidation of fatty acid
    Deficit of an omega-3
    Deficit of an omega-6
    Deficit of an omega-9
    Deficit of total carnitine
    Deficit of free carnitine
    Endothelial activation
    Platelet activation
    Reduced sulfation capacity
    Reduced total sulfate
    Low sulfur amino acid
    Low sulfur compounds
    Low levels of iron-sulfur
    clusters
    Sulfate loss via urine
    Sulfate loss via urine

    You might also like