Pathology Assignment

MD 4 Summer 2015
1. Please draw the Hematopoiesis flow chart from Stem cell to mature
cell (both Myeloid and lymphoid series).
2. Explain in a flowchart - hemolytic anemia leading to gall stones
3. What are the lab findings in intravascular hemolysis and extra
vascular hemolysis
4. Explain hereditary spherocytosis
5. What are Heinz bodies, Howell Jolly bodies
6. For each of the following give few conditions where we see those
cells in peripheral blood and reasons that are causing appearance of
those cells in each condition
a. Anisocytosis
b. Poikilocytosis
c. Tear drop cell
d. Bite cell
e. Schistocyte
7. How G6PD deficiency can lead to hemolytic anemia, please write
flow chart of G6PD role in production of NADPH and break down of
H2O2
8. Please write down pathophysiology of sickle cell anemia
9. How sickle cell anemia can lead to autosplenectomy
10. Explain both alfa and beta thalssemias in detail ( including
subtypes)
Iron deficiency Anemia
11. Explain absorption and transportation of Iron in to the body
12. What is the normal iron content in the body
13. What are transferrin, haptoglobin, hepcidin, total iron binding
capacity
14. Pathogenesis Anemia of chronic disease can lead to iron deficiency
anemia
15 Lab findings in Anemia of chronic disease
Megaloblastic anemia:
16. How B12 & folic acid deficiency can lead to megaloblastic anemia (
flow chart)
17. Differences between folate and megaloblastic anemias and lab
differences

18. How B12 is absorbed in the body

19. Pathogenesis of Aplastic anemia
20 What is myelophthisic anemia
21. Explain the difference between leukemia and leucocytosis and how
do we differentiate in lab
22. Please write a note on diagnostic procedures discussed in this
article http://blogs.nejm.org/now/index.php/a-girl-withseizures/2015/05/22/
23. What is the molecular pathogenesis of leukemias and lymphomas
24. Explain Burkitts lymphoma
25. Explain Reed sternberg cell and its effect on immunity and
inflammation
26. Write down 'practical classification of NHL' .
27. For each of the type of NHL write down
a. Predominant cell
b. CD marker
c. Translocation if any
d. Signs and symptoms
28. Explain Mycosis Fungoides, pathology and signs and symptoms
29. For ALL, AML, CLL, CML please write down
a. Trans location
b. Predominant cell
c. Signs and synptoms
30. Please write down WHO classification of Hodkins Lymphoma
31. Please draw the flowcytometry of AML and ALL.
32. Explain various types of Plasma cell dyscrasias and how do we
differentiate each from each other
33. Explain translocation 9/22 and how it can lead to leukemia
34. Please draw flow chart of coagulation cascade explaining intrinsic
and extrinsic pathways.
35. What are Bernard soulier syndrome and glansman thromboesthenia
36. What are normal PT and aPTT.
37. Why there can be DIC in AML 3
38. What is plummer winson syndrome

PS: Some questions about leukemias are repeated from in class

assignment. If you did submit them already, you don't have to do it
again. Study it again though. :)
The objective of this assignment is that you study the topic in detail.
Good luck. Good day.