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A Clinical Study of The Korotkoff Phases of Blood Pressure in Children
A Clinical Study of The Korotkoff Phases of Blood Pressure in Children
ORIGINAL ARTICLE
Introduction
The measurement of blood pressure using the Korotkoff method is done by listening over the brachial
artery during deflation of an upper arm cuff. In 1905
Korotkoff1,2 described three different sounds that
could be distinguished by listening with a stethoscope placed over the brachial artery. The original
description of the sounds has been slightly modified
over the years and we now recognise four different
types of sound (and five phases).2
The pressure in the mercury sphygmomanometer
when the first sounds are heard represents systolic
blood pressure and there is continuing debate as to
whether disappearance (phase V) or muffling of
sounds (phase IV) best represents diastolic pressure
in children.3 Even though it is recognised that phase
V (disappearance of sounds) may be absent in children, the presence or otherwise of the other four
phases has not been described. This study describes
Correspondence: Dr John OSullivan, Department of Paediatric
Cardiology, Freeman Hospital, Newcastle upon Tyne, NE7 7DN,
UK. E-mail: J.J.Osullivanncl.ac.uk
Received 22 May 2000; revised 5 August 2000; accepted 11
August 2000
198
Figure 1 The figure shows the arm cuff which is inflated automatically and which is deflated at an approximate constant rate.
The stethoscope is connected to a microphone, allowing the
investigator to listen through headphones to the sounds being
recorded onto MiniDisc.
The Korotkoff phases were identified by the character of the sounds, as outlined by Geddes;2 phase I
sounds are loud with a clear-cut and snapping tone,
phase II sounds have a murmur-like quality, phase
III sounds are similar in character to first phase
sounds, and phase IV sounds have a dull or muffled
tone. The fifth phase represents the complete disappearance of the sounds. One of the investigators
(JOS) allocated each of the sounds to one of these
phases and repeated it 2 months later (blinded) to
check consistency. Since the cuff deflated rapidly
below 30 mm Hg it was not possible to say if phase
V was absent, but for the purposes of analysis, if
sounds persisted to 30 mm Hg then phase V was
said to be absent. If the first sounds heard had a murmur-like quality then phase I was said to be absent.
The number of beats heard in phases I to IV was
counted and the length of each phase measured.
Statistical methods
The relationship between the blood pressure and
arm circumference was analysed using standard
regression plots. The differences in phase lengths
and also arm circumference for the phase groups
were assessed using the Mann-Whitney test. The
inter-relationship between phases II and III was
assessed using the Chi-squared test. In assessing
paired differences in repeat data the confidence
intervals of 2 standard deviations about a mean difference level, as recommended by Bland and Altman, were calculated.5
Measurement procedure
Results
80.2
99.9
61.7
22.8
150.8
(11.4)
(9.2)
(9.2)
(4.5)
(27.4)
Female
83.8
99.7
63.1
23.3
150
(12.3)
(9.6)
(9.5)
(4.5)
(8.8)
The largest difference was in phase IV with a difference of less than one beat. The discrepancy in phase
IV sounds (muffling) was due to their low amplitude
and these sounds faded rather than abruptly ceased
making it difficult to decide whether the sound had
disappeared or was still faintly present.
199
Discussion
The only previous studies on the clinical description of all Korotkoff phases in the literature were
undertaken in adults over 80 years ago. Swan6
described the Korotkoff phases in 200 adults. All
phases were present in about 40% and phase IV was
detected in less than half of the subjects. Goodman
and Howell7,8 measured the proportion of the pulse
pressure that the phases occupied and reported that
Journal of Human Hypertension
200
Table 2 The table shows the different patterns of phases present in the 70 children. The area is shaded if that phase is present. No. =
number of children with the different patterns of phase distribution
I
II
III
IV
No. (=70)
28
15
7
6
5
3
2
1
1
1
1
68
43
36
Figure 3 The duration of the Korotkoff sounds for each individual was measured and the proportion occupied by each phase
calculated. These proportions are presented in the figure (median
Inter-quartile range (IQR)) for each phase and for the two
occasions when the sounds were assessed. The numbers 1 and 2
on the figure refer to the first and second assessments
(respectively) of the recordings.
62
56
Figure 5 Children were divided into those with (yes) and those
without (no) phase V. The difference in arm circumference
between these two groups is presented with each individual
value shown as an open circle and the group median ( Interquartile range) as the closed circles.
be present in children with larger arm circumference. Arm circumference is positively associated
with increasing height and weight and therefore
larger arm circumference may be the main explanation for the fact that phase V is virtually always
present in normal adults. However other factors
such as pulse pressure and arterial wall compliance
may also be important. As there is no consensus on
how the Korotkoff phases are produced,9,10 one can
only speculate as to the significance of the observed
variation in the presence and length of the phases in
children with similar blood pressure. The apparent
differences between our findings and those reported
in historical adult studies6,7 might suggest that
arterial wall compliance is an important factor, but
methodological differences between the studies
make comparisons difficult.
Our study also provides some insights into the
problems of accurate diastolic blood pressure
measurement in children. It was clear that phase IV
(muffling) sounds are of low amplitude and often
difficult to hear. Under the optimal listening conditions of our study phase IV could not be detected
in 12% of children. The difficulty with the reliable
detection of phase IV is highlighted by the widely
different results of two large studies. A Finnish
study found that phase IV sounds were not detected
in 3% of over 1000 12-year-old children11 and an
American study on children aged 1015 years found
no phase IV in over 50%.12 Using phase V for diastolic blood pressure measurement is also prone to
error as the phase IV sounds generally fade rather
than abruptly cease. The small difference in the
length of phase IV when the recordings were reanalysed suggests that under standard clinical conditions the reproducibility would be much poorer.
This was the case in a study on between- and
within-visit variance of blood pressure, which concluded that diastolic blood pressure (using phase IV
or V) was a strikingly imprecise measurement for
children aged 812 years.13
Our study describes in detail the Korotkoff phases
detectable in normal children under optimal listening conditions. This is the first study to describe all
the Korotkoff phases in children and it provides
insight into the problems of accurate clinical
measurement of diastolic blood pressure in this age
group. It is noteworthy that almost 100 years since
their initial description we have made little progress
201
Acknowledgements
We are grateful to the parents, teachers and children
of Heaton Manor school who supported the study,
and to Mrs Toni Allen who helped to organise the
study and was funded by the Childrens Heart Unit
Fund (CHUF). The equipment for this study was
purchased by a grant from the Freeman Hospital
Special Trustees.
References
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