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Pengaktifan Limfosit TN
Pengaktifan Limfosit TN
Pengaktifan Limfosit TN
Outlines
Development in primary
lymphoid organs
Activation in secondary or
peripheral lymphoid
organs
Outlines:
STRUCTURE OF T CELL
RECEPTOR
T cells
TCR Complex
Complete functional receptor
complex contains :
heterodimers associated with
the six invariant accessory
chains - signalling protein [a
complex of four other signaling
chains -two , one , one collectively called CD3 and a
homodimer of chains]
ITAM (Immunoreceptor
tyrosine based activation
motifs)
5
T CELL DEVELOPMENT
Immature T
cells
Mature T cells
Thymus
10
The numbers of
human T-cell
receptor gene
segments and the
sources of T-cell
receptor diversity
11
Double
negative
thymocytes
Double positive
thymocytes
T cell receptor
CD4+ CD8+
12
No interaction die
Thymic epithelial cell
Interaction
survive
and become single
positive thymocytes
CD4+ OR CD8+
13
Double positive
thymocytes
Double
positive
thymocytes
T cell receptor
CD4+ CD8+
Single positive
thymocytes
T cell receptor
CD4+ OR CD8+
14
Single positive
thymocytes
Interaction die
(removal of self reactive cells)
No interaction survive
15
Positive selection
Negative selection
16
17
Activated dendritic
cells from tissue
meet nave T cells
in T cells area of
secondary
lymphoid organs
APCs deliver three kinds of signals for the clonal expansion and
differentiation of naive T cells
20
21
22
23
24
25
CD4+ helper
T cells
Infected tissue
26
Activation signals
should be
stopped:
Negative feedback
of TCR signaling
27
Developmental Phase
28
29
30
Interfolliculer area
31
32