PHARMACOLOGIC MANAGEMENT

DRUG CLASS
EFFICACY
SAFETY
TREATMENT FOR HYPERTENSION
It increases the rate of urine Erectile dysfunction, gout,
DIURETICS
flow, excretion of Na and other hyponatremia,
accompanying ions, usually Cl.
hypercalcemia
and
arrhythmias
Loop

Thiazide

BetaBlockers

ACE
Inhibitors

Increases excretion of water by

interfering
with
chloridebinding cotransport system,
which in turn inhibits sodium
and chloride reabsorption in
the ascending loop of Henle
and distal tubule.
Inhibits Na-K-Cl symporter in
the
distal
renal
tubules,
resulting in increased excretion
of Na, water and K.
Beta blockers primarily block
1 and 2 receptors and
thereby
and
thereby
the
effects of norepinephrine and
epinephrine. By blocking the
effects of norepinephrine and
epinephrine,
beta
blockers
reduce
heart
rate;
reduce blood
pressure by
dilating blood vessels
Prevents
conversion
of
angiotensin I to angiotensin II,
which
is
a
potent
vasoconstrictor, resulting in
lower aldosterone secretion.

SUITABILITY
Helps our patient to get rid
of excess salt and fluid
helps lower blood pressure
and can make it easier for
the heart to pump.

Hyperuricemia,
hypokalemia, anaphylaxis,
glycosuria.

Scaling eczema, StevenJohnsons syndrome, TEN,

disorder of hematopoietic
structure, hepatotoxicity
Beta blockers should not
be withdrawn suddenly
because
sudden
withdrawal may worsen
angina (chest pain) and
cause heart
attacks or sudden death.

First line treatment for

hypertension.

Used with caution to

patients with congestive
heart failure. Do not use
in
patiens
with
hypersensitivity.
Side/Adverse
effects:
Hyperkalemia,
hypersensitivity reactions,
hypotension, cough, chest
pain,
palpitations,
proteinuria.

It is suitable for the patient

because of its faster
remodeling of the heart. Its
effect is more on
hemodynamic and not on
the structural effect.

It is suitable for the patient

because it can reduce the
patients heart rate.

Should be taken on an
empty stomach. Take 1hr
before or 2hr after meals.

Calciumchannel
blockers

It relaxes coronary smooth

muscle and produces coronary
vasodilation which improves
myocardial oxygen delivery.

TREATMENT FOR HIGH TOTAL CHOLESTEROL

Competitively inhibits HMGStatins
CoA reductase, the enzyme
that catalyses the conversion
of HMG-CoA to mevalonate.
This results in the induction of
the
LDL
receptors
and
stimulation of LDL catabolism,

Edema,
pulmonary
edema,
headache,
fatigue,
palpitations,
dizziness,
nausea,
flushing, abdominal pain,
somnolence.

It is suitable for our

hypertensive patient
because it can improve the
myocardial oxygen delivery
and coronary vasodilation.

Adverse Effects:
Chest
pain, face edema, fever,
neck
rigidity,
malaise,
photosensitivity reaction,
generalized edema.

Reduces LDL-cholesterol,
apolipoprotein B &
triglycerides; increases
HDL-cholesterol in the
treatment of
hyperlipidemias.

leading
to
lowered
cholesterol levels.
P-DRUGS
DRUG CLASS
DIURETIC
Hydrochlorothiazide
(Diuzid)
25 mg given 1tab
once a day
BETA-BLOCKER
Atenolol (Tenorvas)
25mg given1/2tab
once daily

ACE INHIBITOR
Captopril (Hartylox)
25 mg 1 tab twice a
day

LDL-

EFFICACY

SAFETY

Inhibits Na-K-Cl symporter in

the
distal
renal
tubules,
resulting in increased excretion
of Na, water and K.

Scaling eczema, StevenJohnsons syndrome, TEN,

disorder of hematopoietic
structure, hepatotoxicity

SUITABILIT
Y
First line
treatment for
hypertension
.

Beta blockers primarily block

1 and 2 receptors and
thereby
and
thereby
the
effects of norepinephrine and
epinephrine. By blocking the
effects of norepinephrine and
epinephrine,
beta
blockers
reduce
heart
rate;
reduce blood
pressure by
dilating blood vessels
Prevents
conversion
of
angiotensin I to angiotensin II,
which
is
a
potent
vasoconstrictor, resulting in
lower aldosterone secretion.

Beta blockers should not

be withdrawn suddenly
because
sudden
withdrawal may worsen
angina (chest pain) and
cause heart
attacks or sudden death.

It is suitable
for the
patient
because it
can reduce
the patients
heart rate.

Tenorvas
tab 50mg

Used with caution to

patients with congestive
heart failure. Do not use
in
patiens
with
hypersensitivity.
Side/Adverse
effects:
Hyperkalemia,
hypersensitivity reactions,
hypotension, cough, chest
pain,
palpitations,
proteinuria.

It is suitable
for the
patient
because of
its faster
remodeling
of the heart.
Its effect is
more on
hemodynami
c and not on
the
structural
effect.

Hartylox
tab 25mg

It is suitable
for our
hypertensive
patient
because it
can improve
the
myocardial
oxygen
delivery and
coronary
vasodilation.
Reduces
LDLcholesterol,
apolipoprotei
n
B
&
triglycerides;
increases
HDLcholesterol in
the
treatment of
hyperlipidem

Calcibloc
cap 10mg

Should be taken on an
empty stomach. Take 1hr
before or 2hr after meals.
CALCIUM CHANNEL
BLOCKER
Nifedipine (Cacibloc)
10mg 1cap twice a
day

It relaxes coronary smooth

muscle and produces coronary
vasodilation which improves
myocardial oxygen delivery.

Edema,
pulmonary
edema,
headache,
fatigue,
palpitations,
dizziness,
nausea,
flushing, abdominal pain,
somnolence.

STATINS
Atorvastatin
(Avamax)
10mg once daily

Atorvastatin
competitively
inhibits HMG-CoA reductase,
the enzyme that catalyses the
conversion of HMG-CoA to
mevalonate. This results in the
induction of the LDL receptors
and
stimulation
of
LDL
catabolism, leading to lowered
LDL-cholesterol levels.

Adverse Effects:
Chest
pain, face edema, fever,
neck
rigidity,
malaise,
photosensitivity reaction,
generalized edema.

COST
Diuzid tab
25mg
P4.25/tab

P8.75/tab

100s
P843/pack

100s
P2334.76/p
ack

Atorvastati
n 10mg/tab
P26.00/filmcoated tab

ias.