Jessica Li Resume Page 1 of 2

Bo (Jessica) Li
3925 Long Ridge Blvd.
Westfield, IN 46074
Email: jessli_09@yahoo.com
Cell phone: 317-698-2337

Visa Status:
Permanent residence

Skill Summary:
1. Working experience in developing methods for complex chemical testing, complying
with GMP/GLP.
2. Excellent skills in instrumental analysis including DESI-MS, LC-MS, GC, HPLC, UV-
Vis, IR, NMR and Fluorescence Spectrophotometer.
3. Solid knowledge in organic chemistry, analytical chemistry and
biochemistry.
4. Excellent skills in solid-phase synthesis and purification of compounds.
5. Sound computer skills including MS Excel, MS Word, MS PowerPoint and
ChemBioDraw.
6. Adaptive to new technique, hard working.
7. Ability to consistently conduct multiple routine tasks, procedures, and operations
concurrently.
8. Teaching and mentor skills.

Professional Experience:
2009 - Present Prosolia Inc. R & D chemist
• Develop and optimize method (full scan, SRM, MRM) to analyze samples with DESI-
MS (LTQ, TSQ):
 Perform wet chemistry assays by MS within GLP environment.
 Analyze solid samples and preparing sample solutions to analyze on glass slide.
 Extract ganglioside from tissue and analyzing the extraction using coupled DESI-
MS (LTQ) mass spectrometry and thin-layer chromatography (TLC).
 Analyze drug metabolism in CYP human liver microsome by DESI-MS (TSQ)
mass spectrometry.
 Image:
➢ Cut different thickness tissues (rat brain, gland and liver) with a cryostat
at -22 °C and thawing the tissue section on a glass slide.
➢ Scan the image of tissue section in full scan and MSMS mode with
DESI-LTQ to distinguish between cancerous and non-cancerous tissue
samples using multiple marker lipids and to measure the distributions of
drugs and their metabolites in tissue.
➢ Convert the data to image using Firefly and Biomap software.
• Analyze data, and submit written report to the director weekly.
• Publish research notes on company’s website.
• Maintain instrument.
• Classify chemicals, update inventory and dispose waste (chemicals and biohazards).

Research & Lab Experiences:

Dr. Eric C. Long’s Lab, Chemistry & Chemical Biology, Indian University,
 Jessica Li Resume Page 2 of 2

Purdue University, Indianapolis

• Synthesize peptides and compounds with DNA binding activity using solid-phase
chemistry.
• Develop methods to purify synthesized compounds using chromatography like HPLC and
Flash Column (2 years).
• Develop methods to verify compounds by instrumental analysis such as LC-MS (3
years), GC, IR and NMR. Use UV-Vis to quantitate concentration of peptides and DNA,
obtain λmax and calculate extinction coefficient of new compounds.
• Confirm binding affinity and selectivity of compounds to DNA by High Throughput
(HT) - Fluorescence Intercalate Displacement (FID) Assay to find potential anti-cancer
drugs.
• Maintain appropriate inventories of all laboratory materials. All of the operations follow
GLP operations.
Professor Fangming Miao’s Lab, Chemistry Department, Tianjin Normal
University
• Synthesize metal alcoholates using solution-phase chemistry.
• Culture crystals of compounds.
• Determine crystal structure of compounds by x-ray diffraction.

Teaching Experiences:
• Teach undergraduate Organic Chemistry Lab as a TA.
• Guide undergraduate’s research.

Education:
• Indiana University, Purdue University, Indianapolis
M.S., Biochemistry
• Tianjin Normal University
M.S., Physical Chemistry
• Tianjin Normal University
B.S., Chemistry

Publications:
1. Li, Bo M.S. thesis: Design, synthesis and FID analysis of DNA minor groove
binding : amino acid-benzimidazole conjugates.
2. Opperman T. J.; Li, J. B.; Lewis M.A.; Houseweart C.; Aiello, D.; Williams J.d.; Peet, N.
P.; Moir, D.T.; Long, E. C.; Bowlin T. L. DNA binding activity of novel bis-indole
antibiotics (to be published).
3. Wang, Jinling, Li, Guiping, Zhang, Lijuan, Li, Bo, Ma, shikun, Niu, Zhongcheng and
Miao, Fangming Sodium 1-Naphthylamine-6-sulfonate-Water (1/4) Acta Cryst.
(1996). C52. 2476-2477.
4. Wang, Jinling, Li, Bo, Miao, Fangming Crystal Structure of 1-Aminonaphthyl-6-
sulfonate Hexaqua-magnesium (II) Hexahydrate Chinese J. Struct. Chem. (1994)
Vol. 13, No. 4