Professional Documents
Culture Documents
Μεταβολικό Σύνδρομο
Μεταβολικό Σύνδρομο
,
. .
. &
To
.
, .
,,
.
(.. 10 ) , Framingham risk score.
..
.
.
.
27
,
. (.)
. (
), , 1.
..
: WHO ( ) , NCEP ATP III (
), IDF ( ), NCEP-R
( NHLBI).
..
(NCEP) 10 ( 2009
NCEP-R)
.2.
. .
. . .
Olivetti heart study3, ,
. .
. , . . EGIR
AACE (.. ) 16% 8,6%.
WHO, ATPIII, NCEP-R, IDF (.. )
23%, 29%, 35%, 44%.
. .
, ,
. 4.
(. .)
,
(
) 5.
, ,
adiponectin (
, , ,
) . .
6 ( : , ,
, ) . .
( -).
stress (
, IGF-1, ,
).
, . . 7,8.
( )
.. (..)
,
. .,
.
. ..;
. .;
..
;
..
. . . KUOPIO 9 . .
(RR=2,43) (RR=3,77).
37 17.200 (Gami et al 2007)10
. 1,74 (1,54)
..
: .
..
,
.
: . . .
. IDF
( )11.
. . .
.. 40.000
4 .
(HR) = 4.3 ,
.
700
10
. . -
HDL12.
:
. .,
. IDF ..
.
..
.
, : .
Framingham score
c-statistic ROC 14.
. .
,
, 15
..
ADA EASD
.,
..
life style
.16,17
, ,
, .
. .
. (WHO) Diabetologia 2010
. .
: Our best wishes for the
Metabolic Syndrome. Rest in peace. 18
, 2010
. (87 951.000 ) 19
(
).
5 2
(RR=2,5 RR=1,6 )
.
WHO 2010.
.
(circulatory)
,
(, GFR,
, , . ).20
stress, ,
. . .
.
.21
95%
.
...
, 2015
.22
, ,
.
.
:
To
,
.
,,
.
(.. 10 ) , Framingham
risk score.
..
.
.
.
Abstract
Metabolic syndrome is a cluster of metabolic risk factors and defines the need
for clinical treatment of obese who have multiple additional risk factors. Nowadays
there is a tendency of evolution of metabolic syndrome in a syndrome of renal,
cardiac and vascular indices which contribute to atherosclerosis and exacerbate
vascular endothelial dysfunction.
Metabolic syndrome can not be considered as a predictor in cardiovascular
risk assessment models with a short study period (e.g., 10-year risk), such as the
Framingham risk score.
The presence of metabolic syndrome is closely linked with an increased risk
of diabetes and cardiovascular disease development. It is also associated with the
urgent need to assess the overall cardiovascular risk and the presence of subclinical
atherosclerosis by noninvasive imaging.
Metabolic syndrome can bring together the fields of cardiovascular disease
and diabetes in an effort to limit the risks of both aforementioned situations.
1. . . :
. . . 2007
Bckhed, et al
9. Lakka HM,, Laaksonen DE, Lakka TA et al The metabolic syndrome and total
and
cardiovascular
disease
mortality
in
middle-aged
men.
JAMA. 2002;;288(21):2709-16.
10. S. Gami, B. J. Witt, D. E. Howard et al Metabolic Syndrome and Risk of
Incident Cardiovascular Events and Death : A Systematic Review and MetaAnalysis of Longitudinal Studies J.
2007;49:403-414
11. Athyros VG, Ganotakis ES, Elisaf MS et al Prevalence of vascular disease in
metabolic syndrome using three proposed definitions. Int J Cardiol.
2007;117(2):204-10
12. L. Guize, F. Thomas, B. Pannier et al All-Cause Mortality Associated With
Specific Combinations of the Metabolic Syndrome According to Recent
Definitions Diabetes Care September 2007 30:2381-2387
13. I. Protopsaltis, Georgios Nikolopoulos , Melidonis A, et al Metabolic syndrome
and its components as predictors of all-cause mortality and coronary heart
disease in type 2 diabetic patients Atherosclerosis 195 (2007) 189194
14. M. P. Stern, K. Williams, C. Gonzlez-Villalpando et al Does the Metabolic
Syndrome Improve Identification of Individuals at Risk of Type 2 Diabetes
and/or Cardiovascular Disease? Diabetes Care 2004 27:2676-2681
19. Mottillo S, Filion KB, Genest J, et al. The metabolic syndrome and
cardiovascular risk a systematic review and meta-analysis. J Am Coll
Cardiol. 2010;56:11131132
N.
Straznicky, E.
- :
Key-words:
Metabolic Syndrome
Insulin Resistance
Circulatory Syndrome
Central obesity