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Document 1 of 1

IgE, Mast Cells, and Eosinophils in Atopic Dermatitis

Author: Liu, Fu-tong; Goodarzi, Heidi; Chen, Huan-yuan
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Abstract: Issue Title: Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and
inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but
is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This
review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The
known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and
eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of
IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by
abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is
supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of
mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in
AD lesions and the association between mast cell activation and AD. It is further suggested by
their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can
affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD
patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD
to cytokines and chemokines associated with production, recruitment, and activation of
eosinophils.[PUBLICATION ABSTRACT]

MeSH: Animals, Humans, Dermatitis, Atopic -- immunology (major), Eosinophils -- immunology

(major), Immunoglobulin E -- immunology (major), Mast Cells -- immunology (major)
Substance: Immunoglobulin E;
Publication title: Clinical Reviews in Allergy & Immunology
Volume: 41
Issue: 3
Pages: 298-310
Publication year: 2011
Publication date: Dec 2011
Year: 2011
Publisher: Springer Science & Business Media
Place of publication: Totowa
Country of publication: Netherlands
Publication subject: Medical Sciences--Allergology And Immunology
ISSN: 10800549
Source type: Scholarly Journals
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Language of publication: English

Document type: Feature, Journal Article
DOI: http://dx.doi.org/10.1007/s12016-011-8252-4
Accession number: 21249468
ProQuest document ID: 896020631
Document URL: http://search.proquest.com/docview/896020631?accountid=50673
Copyright: Springer Science+Business Media, LLC 2011
Last updated: 2014-08-30
Database: ProQuest Medical Library

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