Professional Documents
Culture Documents
Defining Uterine Tachysystole: How Much Is Too Much?: Obstetrics
Defining Uterine Tachysystole: How Much Is Too Much?: Obstetrics
www. AJOG.org
OBSTETRICS
creasing number of contractions per 10 minutes. Six or more contractions in 10 minutes were significantly associated with fetal heart rate
decelerations (P .001). Analysis was performed using the maximum
number of contractions per 30 minutes with similar results.
Cite this article as: Stewart RD, Bleich AT, Lo JY, et al. Defining uterine tachysystole: how much is too much? Am J Obstet Gynecol 2012;207:290.e1-6.
290.e1
Obstetrics
www.AJOG.org
TABLE 1
Demographic characteristics in
584 women undergoing labor
induction
Characteristic
No. of women,
n 584
Parity
..................................................................................................
288 (49)
112 (19)
..................................................................................................
..................................................................................................
184 (32)
...........................................................................................................
Epidural
370 (63)
...........................................................................................................
Maternal age, y
25.9 6.3
...........................................................................................................
Race/ethnicity
..................................................................................................
Hispanic
465 (80)
..................................................................................................
African American
70 (12)
White
32 (5)
Other
17 (3)
..................................................................................................
..................................................................................................
...........................................................................................................
Pregnancy
complications
..................................................................................................
Diabetes
63 (11)
..................................................................................................
Hypertension
141 (24)
Severe
preeclampsia
89 (15)
..................................................................................................
..................................................................................................
Abruption
..................................................................................................
Premature ruptured
membranes
164 (28)
Postterm induction
151 (26)
..................................................................................................
...........................................................................................................
associated decelerations, we would continue to monitor for evidence of fetal distress, however the second dose of misoprostol would not be administered.
At the conclusion of labor, the paper
copy of the FHR tracing was collected.
The contraction patterns were recorded
with tocodynamometer unless an intrauterine pressure catheter was placed for
obstetrical indications. These tracings
were subsequently analyzed by visual assessment for the number of contractions
per each 10-minute epoch during the
initial 4 hours of misoprostol induction.
In addition, for each 10-minute epoch
the presence of uterine hypertonus, defined as a contraction lasting 120 seconds, was recorded. Similarly, variable,
late, or prolonged decelerations and fetal
tachycardia or bradycardia were recorded, using standard definitions as
outlined by ACOG.2 The time and mode
of delivery was also recorded. All FHR
tracing analysis was conducted by 1 investigator (R.D.S.) who was blinded to
the infant outcomes.
Obstetric and infant clinical outcome
data were obtained using the preexisting
Parkland Hospital obstetric database.
Nurses attending each delivery complete
an obstetric data sheet, and research
nurses assess the data for completeness
and consistency before electronic storage. Data on infant outcomes are also abstracted from discharge records and entered into a separate database. The
outcome of interest for this study was infant condition at birth assessed using a
composite outcome termed the fetal vulnerability composite, which included:
5-minute Apgar scores 3, umbilical artery blood pH 7.1, intubation in the
delivery room, neonatal seizures, admission to intensive care, or perinatal death.
These results were electronically linked
to the previously collected FHR tracing
analyses. Patients were then divided into
4 groups based on the greatest number of
contractions within any 10-minute epoch during the initial 4 hours of labor
induction: 4, 5, 6, 7 contractions per
10 minutes. Analysis was also performed
using the maximum number of contractions per 10 minutes averaged over 30
minutes.
Research
R ESULTS
A total of 584 women undergoing induction of labor with misoprostol were analyzed. Maternal demographic characteristics and pregnancy complications are
shown in Table 1.
Of the women undergoing induction,
253 (43%) had at least one 10-minute
epoch with 6 contractions during the
initial 4 hours of induction; however
when averaged over 30 minutes, 129
(22%) of the 584 women met this criteria
for uterine tachysystole. Of the 584
women within the cohort, 253 (43%) required oxytocin infusion. Intrauterine
pressure catheters were placed in 519
women (89%) during their labor. Infant
outcomes, both the composite and individual components of the composite, according to number of uterine contractions per 10 minutes during the first 4
hours of induction are shown in Table 2. The fetal vulnerability composite
showed no association with increasing
number of uterine contractions, and no
individual component was significantly
associated with increasing number of
uterine contractions. Route of delivery
similarly showed no association with the
number of contractions per 10 minutes.
When the infant outcomes were analyzed
using the number of contractions averaged
290.e2
Research
Obstetrics
www.AJOG.org
TABLE 2
<4, n 152
5, n 179
6, n 134
>7, n 119
P value
5 (3)
6 (3)
2 (1)
6 (5)
.86
5-min Apgar 3
1 (1)
.86
1 (1)
4 (2)
2 (1)
6 (5)
.06
Seizures
Intubation at delivery
1 (1)
.11
Stillborn
Neonatal death
NICU admission
5 (3)
3 (2)
1 (1)
.03
.18
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
a
................................................................................................................................................................................................................................................................................................................................................................................
Route of delivery
.......................................................................................................................................................................................................................................................................................................................................................................
Cesarean
31 (20)
35 (19)
26 (19)
17 (14)
.34
121 (80)
144 (81)
108 (81)
102 (86)
.28
.......................................................................................................................................................................................................................................................................................................................................................................
Vaginal
................................................................................................................................................................................................................................................................................................................................................................................
All data shown as n (%) unless otherwise indicated. P value is for Mantel-Haenszel 2 for trend.
NICU, neonatal intensive care unit.
a
the composite (Table 3). However, admission to neonatal intensive care was
associated with decreasing uterine contractions when analyzed per 10 minutes
or per 30 minutes (P .03 and P .04).
TABLE 3
<13, n 292
14-16, n 163
10 (7)
17-19, n 83
>20, n 46
P value
3 (2)
2 (1)
4 (3)
.82
.......................................................................................................................................................................................................................................................................................................................................................................
5-min Apgar 3
1 (1)
.33
4 (3)
3 (2)
2 (1)
4 (3)
.06
Seizures
Intubation at delivery
1 (1)
.33
Stillborn
Neonatal death
NICU admission
8 (3)
1 (2)
.04
.03
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
.......................................................................................................................................................................................................................................................................................................................................................................
................................................................................................................................................................................................................................................................................................................................................................................
a
................................................................................................................................................................................................................................................................................................................................................................................
Route of delivery
.......................................................................................................................................................................................................................................................................................................................................................................
Cesarean
65 (22)
26 (15)
12 (14)
6 (13)
.02
137 (85)
71 (86)
40 (87)
.04
.......................................................................................................................................................................................................................................................................................................................................................................
Vaginal
227 (78)
................................................................................................................................................................................................................................................................................................................................................................................
All data shown as n (%) unless otherwise indicated. P value is for Mantel-Haenszel for trend.
NICU, neonatal intensive care unit.
2
290.e3
Obstetrics
www.AJOG.org
Research
TABLE 4
<4,
n 152
5,
n 179
6,
n 134
>7,
n 119
P value
<13,
n 292
14-16,
n 163
17-19,a
n 83
>20,
n 46
P value
Any
61 (40)
88 (49)
77 (57)
69 (58)
.001
125 (43)
94 (58)
48 (58)
28 (61)
.001
Variable
48 (32)
78 (44)
64 (48)
62 (52)
.001
102 (35)
84 (52)
41 (49)
25 (54)
.001
Late
24 (16)
38 (21)
34 (25)
31 (26)
.02
54 (18)
38 (23)
24 (29)
11 (24)
.05
Prolonged
10 (7)
16 (9)
17 (33)
19 (16)
.017
24 (8)
19 (12)
9 (11)
10 (22)
.03
................................................................................................................................................................................................................................................................................................................................................................................
a
a
................................................................................................................................................................................................................................................................................................................................................................................
a
a
................................................................................................................................................................................................................................................................................................................................................................................
a
a
................................................................................................................................................................................................................................................................................................................................................................................
Cutpoint for threshold of most significant P value based on minimum P value technique and adjusted with Bonferroni technique.
C OMMENT
Increasing uterine activity during the
first 4 hours of labor induction, quantified as the maximum number of contractions in 10 minutes, or per 30 minutes,
had variable effects depending upon the
outcome of interest. For example, adverse infant outcomes were not related to
the number of uterine contractions per
time period. On the other hand, increased number of contractions per 30
minutes was associated with a significantly increased rate of vaginal birth, and
consequently the opposite effect on cesarean delivery. Time from misoprostol
administration to delivery was also significantly shorter with increased number
of contractions per 30 minutes. Similarly, increased uterine activity, defined
as 6 contractions per 10 minutes and
17-19 per 30 minutes, was associated
with increased FHR decelerations.
Lastly, uterine hypertonus was associated with increased late and prolonged
290.e4
Research
Obstetrics
www.AJOG.org
TABLE 5
0, n 495
1, n 70
85 (17)
17 (24)
2, n 19
7 (37)
P value
.013
..............................................................................................................................................................................................................................................
Decelerations
.....................................................................................................................................................................................................................................
Any
237 (48)
46 (66)
12 (63)
.006
Variable
208 (42)
38 (54)
6 (32)
.54
Late
93 (19)
23 (33)
11 (58)
.001
Prolonged
38 (7)
20 (29)
4 (21)
.001
.....................................................................................................................................................................................................................................
.....................................................................................................................................................................................................................................
.....................................................................................................................................................................................................................................
..............................................................................................................................................................................................................................................
5-min Apgar 3
1 (0.2)
.69
1 (1)
.69
..............................................................................................................................................................................................................................................
12 (2)
..............................................................................................................................................................................................................................................
NICU admission
9 (2)
.23
Intubation at delivery
1 (0.2)
.69
..............................................................................................................................................................................................................................................
..............................................................................................................................................................................................................................................
cally quite difficult without the placement of an intrauterine pressure catheter because of the much increased
uterine contraction frequency and intensity. Intrauterine pressure catheters
were only placed for routine obstetrical
indications, and therefore were not
placed in all patients. Secondly, we
wanted to study uterine tachysystole in
the setting of labor stimulation because this is the most common clinical
scenario when attention is focused on
uterine tachysystole, and therefore has
the potential to alter management decisions. Thirdly, we chose the labor
pattern following a single dose of misoprostol stimulation because we presumed that standardization of the misoprostol dose as was done would also
serve to standardize the circumstances
under which we were analyzing uterine
tachysystole. Taken together, all these
aforementioned caveats limit our conclusion that brief periods of uterine
tachysystole do not harm the fetus.
Said another way, our results can be
interpreted to mean that self-limited
episodes of uterine tachysystole occurring as a result of labor stimulation remote from delivery are not harmful.
We cannot address the issue as to
whether uterine tachysystole produced
enough intrapartum compromise to result in long-term neurological compromise. However, we point out that none
of the infants in our study who experienced episodes of tachysystole had an
umbilical artery pH 7.0, which is an
obligate criterion to define an acute intrapartum hypoxic event sufficient
enough to result in long-term neurologic
morbidity.14
Our findings that vaginal delivery increased, and time to delivery decreased,
with increasing uterine contractions also
suggests that 6 contractions per 10
minutes vs 5 per 10 minutes, averaged
over 30 minutes, may have an advantage.
This potential advantage, however, must
be tempered by the fact that increasing
contractions impact the FHR pattern.
We find that 6 contractions per 10
minutes, or 17-19 per 30 minutes, as well
as uterine hypertonus, have FHR consequences compared to less frequent contractions or no hypertonus, and that the
Obstetrics
www.AJOG.org
number of contractions can significantly
modify the route of delivery. Based upon
these findings, we believe our results suggest continued use of the NICHD and
ACOG definitions of uterine tachysystole as 6 contractions in 10 minutes,
averaged over 30 minutes. Our results,
although showing there is no difference
in infant outcomes when uterine tachysystole occurs remote from delivery, do
show that uterine contractions of 6 per
10 minutes have a discernible impact on
FHR patterns, and as such justify the
continued use of this threshold.
f
REFERENCES
1. Macones GA, Hankins GD, Spong CY, Hauth
J, Moore T. The 2008 National Institute of Child
Health and Human Development workshop report on electronic fetal monitoring: update on
definitions, interpretation, and research guidelines. Obstet Gynecol 2008;112:661-6.
2. American College of Obstetricians and Gynecologists. Intrapartum fetal heart rate monitoring: nomenclature, interpretation, and general
management principles. ACOG practice bulletin
no. 106. Obstet Gynecol 2009;114:192-202.
3. Peebles DM, Edwards AD, Reynolds EOR, et
al. Relation between frequency of uterine contractions and human fetal cerebral oxygen saturation studied during labor by near infrared
spectroscopy. Br J Obstet Gynaecol 1994;101:
44-8.
4. Johnson N, van Oudgaarden E, Montague I,
McNamara H. The effect of oxytocin-induced
hyperstimulation on fetal oxygen. Br J Obstet
Gynaecol 1994;101:805-7.
5. Simpson KR, James DC. Effects of oxytocininduced uterine hyperstimulation during labor
on fetal oxygen status and fetal heart rate patterns. Am J Obstet Gynecol 2008;199:34.e1-5.
6. Lo JY, Alexander JM, McIntire DD, Leveno
KJ. Ruptured membranes at term: randomized,
double-blind trial of oral misoprostol for labor
induction. Obstet Gynecol 2003;101:685-9.
7. Altman DG. Suboptimal analysis using optimal cutpoints. Br J Cancer 1998;78:550-7.
8. Altman DG, Lausen B, Sauerbrei W, Schumacher M. Dangers of using optimal cutpoints in
Research
290.e6