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Hypolipidemic Activity of Caralluma Adscendens On Triton and Methimazole Induced Hyperlipidemic Rats
Hypolipidemic Activity of Caralluma Adscendens On Triton and Methimazole Induced Hyperlipidemic Rats
Hypolipidemic Activity of Caralluma Adscendens On Triton and Methimazole Induced Hyperlipidemic Rats
Abstract
In the United States as well as in India, coronary heart disease is a leading cause of death for both men and
women and large number of epidemiological and experimental evidences have proved that elevated plasma
cholesterol carry high risk of heart diseases. Caralluma adscendens belongs to family Ascalpedaceae has been
used to treat obesity traditionally. According to the literature survey Caralluma adscendens is used as a thirst
quenching agent. Caralluma adscendens contains high amount of pregnane glycoside, flavone glycoside;
Literature survey also showed that pregnane glycoside and flavone glycoside are linked with lowering the risk of
heart disease. So we have carried out present study to evaluate the hypolipidemic activity of Caralluma
adscendens by using various animal models.
Key Words: Hypolipidemic activity, Caralluma fimbriata, Ascalpedaceae, Triton
Introduction
Hyperlipidemia is a collective term used to describe
human conditions when a plasma level of one or
more classes of lipids, namely cholesterol,
triglycerides, phospholipids and fatty acids increases
above normal levels. Hyperlipidemia is one of the
major causes of the development of cardiovascular
disorders. Heart disease is leading cause of death in
India as well as in western country.
Caralluma is a genus in the Asclepiadaceous family.
There are approximately 100 variable species in the
genus. The plant Caralluma adscendens (Roxb) ver.
fimbriata (Ascalpedaceae) is a tender succulents
found wild in Africa, the Canary Islands, India,
Arabia, Southern Europe, Ceylon, and Afghanistan.
It is known as Ranshabar, Makad Shenguli,
Shindala Makadi in Marathi.
The Phytochemistry of genus Caralluma is
characterized by many pregnane glycosides, while
recently megastigmane glycosides also have been
isolated from Caralluma negevensi as well as few
flavones (Bader et al., 2003).
Address for Correspondence:
E-mail: somnath.sakore@cadilapharma.co.in
Tel: +91-9998949344
Received: 15.01.12
Accepted: 28.02.12
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8312**
822.6*
decreasing
high-density
lipoprotein
(HDL)
cholesterol, and increased lipoprotein.
Present study clearly showed that aqueous extract at
a dose of 250, 500, 750 mg/kg/p.o significantly
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