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Unit 6 Learning Guide and Goals: Chapters 15, 20
Unit 6 Learning Guide and Goals: Chapters 15, 20
Students will be able to explain how transcriptional regulators alter chromatin structure to bring
about activation or repression of transcription.
Students will be able to explain how transcription factors act in eukaryotic cells and their role
in regulating gene expression in a combinatorial fashion to bring about cellular differentiation.
Students will gain an appreciation of the potential of different types of stem cells.
Students will be able to explain how different types of genetic misregulation can lead to
disease.
Learning Objectives
November 13
Explain how transcription factors act in a combinatorial fashion to regulate gene expression.
Describe how regulated gene expression leads to cell differentiation.
November 11-14 (Discussion 11)
Explain the difference between spatial, temporal and conditional gene regulation with regards
to cellular differentiation.
Describe how microarray analysis works.
Analyze the results of a microarray experiment in the context of cellular differentiation.
November 18
Arrange the sequence of gene regulation events needed to specify individual segments of the
fruit fly.
Describe the inheritance pattern of maternal-effect genes.
Compare and contrast homeotic genes with homeobox containing genes.
Explain the role of cell-cell interactions in specifying cell fate in the nematode.
Explain shared developmental pathways that exist among diverse organisms, based on
evolutionary relatedness.
November 20
Predict the consequences of genetic mutations on the development process in Drosophila and
humans
Characterize the different types of stem cells, with regards to their developmental potential.
Describe the role chromatin structure plays in restricting cell fates.
Compare and contrast the amount of heterochromatin in stem cells versus differentiated cells.