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Biochemistry MCQs
Biochemistry MCQs
Protein structure which is the folding of short (3- to 30- residue), contiguous
segments of polypeptide into geometri- cally ordered units
a. Primary structure
b. Secondary structure
c. Tertiary structure
d. Quarternary structure
Answer: B
Primary structure is the sequence of the amino acids in a polypeptide chain;
Secondary structure is the folding of short (3- to 30- residue), contiguous
segments of polypeptide into geometrically ordered units; Tertiary structure is
the assembly of secondary structural units into larger functional units such as
the mature polypeptide and its component domains; and Quaternary
structure is the number and types of polypeptide units of oligomeric proteins
and their spatial arrangement.
b. 2,3 Biphosphoglycerate
c. Oxygen
d. Carbon dioxide
Answer: B. 2,3 Biphosphoglycerate stabilizes deoxygenated (T state)
hemoglobin by forming salt bridges that must be broken prior to
conversion to the R state
2. Physiologic changes that accompany prolonged exposure to high altitude:
a. Increase in the number of erythrocytes
b. Elevated BPG
c. Both
d. Neither
Answer: C. Both are physiologic changes that accompany prolonged
exposure to high altitude.
3. Condition following massive crush injury, myoglobin released from damaged muscle
fibers colors the urine dark red.
a. Myoglobinuria
b. Anemia
c. Thalassemia
d. Methemoglobinemia
Answer: A.
Anemias are reductions in the number of red blood cells or of hemoglobin in the
blood; Thalassemias result from the partial or total absence of one or more or
chains of hemoglobin. In methemoglobinemia, the heme iron is ferric rather than
ferrous
Chapter 7: Enzymes: Mechanism of Action
1. Enzyme reaction type which catalyze oxidations and reductions
a. Oxidoreductases
b. Transferases
c. Isomerases
d. Ligases
Answer: A.
Oxidoreductases catalyze oxidations and reductions. Transferases
catalyze transfer of moieties such as glycosyl, methyl, or phosphoryl
groups. Isomerases catalyze geometric or structural changes within a
molecule. Ligases catalyze the joining together of two molecules
coupled to the hydrolysis of ATP.
b. Transferases
c. Isomerases
d. Ligases
Answer: B.
Oxidoreductases catalyze oxidations and reductions. Transferases
catalyze transfer of moieties such as glycosyl, methyl, or phosphoryl
groups. Isomerases catalyze geometric or structural changes within a
molecule. Ligases catalyze the joining together of two molecules
coupled to the hydrolysis of ATP.
Answer: C.
Oxidoreductases catalyze oxidations and reductions. Transferases
catalyze transfer of moieties such as glycosyl, methyl, or phosphoryl
groups. Isomerases catalyze geometric or structural changes within a
molecule. Ligases catalyze the joining together of two molecules
coupled to the hydrolysis of ATP.
Competitive inhibition competes for the binding site. Noncompetitive inhibition bind to
either the enzyme or ES complex. Uncompetitive inhibition react to only ES complex.
Irreversible inhibition chemically modifies the enzyme that generally involves making or
breaking covalent bonds.
3. Inhibition that chemically modifies the enzyme that generally involves making or
breaking covalent bonds
a. Competitive
b. Noncompetitive
c. Uncompetitive
d. Irreversible
Answer: D.
Competitive inhibition competes for the binding site. Noncompetitive inhibition bind to
either the enzyme or ES complex. Uncompetitive inhibition react to only ES complex.
Irreversible inhibition chemically modifies the enzyme that generally involves making or
breaking covalent bonds.
1. The process where knowledge of an individuals genetic profile also will be used to guide
the selection of safe and effective drugs or vaccines.
a. Pharmacogenomics
b. Bioinformatics
c. Computer-Aided Drug Design (CADD)
d. None of the above
Answer A:
Pharmacogenomics is the process where knowledge of an individuals genetic profile also
will be used to guide the selection of safe and effective drugs or vaccines. Bioinformatics
exploits the formidable information storage and processing capabilities of the computer
to develop tools for the collection, collation, retrieval, and analysis of biologic data on a
mass scale. Computer-Aided Drug Design (CADD) employs the same type of moleculardocking algorithms used to identify ligands for unknown proteins.
2. It exploits the formidable information storage and processing capabilities of the computer
to develop tools for the collection, collation, retrieval, and analysis of biologic data on a
mass scale.
a. Pharmacogenomics
b. Bioinformatics
c. Computer-Aided Drug Design (CADD)
d. None of the above
Answer B.
Pharmacogenomics is the process where knowledge of an individuals genetic profile also
will be used to guide the selection of safe and effective drugs or vaccines. Bioinformatics
exploits the formidable information storage and processing capabilities of the computer
to develop tools for the collection, collation, retrieval, and analysis of biologic data on a
mass scale. Computer-Aided Drug Design (CADD) employs the same type of moleculardocking algorithms used to identify ligands for unknown proteins.
3. It employs the same type of molecular-docking algorithms used to identify ligands for
unknown proteins.
a. Pharmacogenomics
b. Bioinformatics
c. Computer-Aided Drug Design (CADD)
d. None of the above
Answer C.
Pharmacogenomics is the process where knowledge of an individuals genetic profile also
will be used to guide the selection of safe and effective drugs or vaccines. Bioinformatics
exploits the formidable information storage and processing capabilities of the computer
to develop tools for the collection, collation, retrieval, and analysis of biologic data on a
mass scale. Computer-Aided Drug Design (CADD) employs the same type of moleculardocking algorithms used to identify ligands for unknown proteins.
Chapter 11: Bioenergetics
1. It is the extent of disorder or randomness of the system and becomes maximum as
equilibrium is approached.
a.
b.
c.
d.
Entropy
Enthalpy
Exergonic
Endergonic
Answer: A
Entropy is the extent of disorder or randomness of the system and becomes maximum as
equilibrium is approached. If G is negative, the reaction proceeds spontaneously with
loss of free energy; ie, it is exergonic. On the other hand, if G is positive, the reaction
proceeds only if free energy can be gained; ie, it is endergonic. Enthalpy is heat.
2. If G is negative, the reaction proceeds spontaneously with loss of free energy; ie, it is
___________
a.
b.
c.
d.
Entropy
Enthalpy
Exergonic
Endergonic
Answer: B
Entropy is the extent of disorder or random- ness of the system and becomes
maximum as equilibrium is approached. If G is negative, the reaction proceeds
spontaneously with loss of free energy; ie, it is exergonic. On the other hand, if G is
posi- tive, the reaction proceeds only if free energy can be gained; ie, it is endergonic.
Enthalpy is heat.
3. If G is positive, the reaction proceeds only if free energy can be gained; ie, it is _____
a. Entropy
b. Enthalpy
c. Exergonic
d. Endergonic
Answer: B
Entropy is the extent of disorder or randomness of the system and becomes maximum
as equilibrium is approached. If G is negative, the reaction proceeds spontaneously
with loss of free energy; ie, it is exergonic. On the other hand, if G is positive, the
reaction proceeds only if free energy can be gained; ie, it is endergonic. Enthalpy is
heat.
a.
b.
c.
d.
Fat
Waxes
Phospholipids
Glycolipids
Answer: A. Fat are esters of fatty acids with glycerol. Waxes are esters of fatty acids
with higher molecular weight monohydric alcohols. Phospholipids are lipids containing,
in addition to fatty acids and an alcohol, a phosphoric acid residue. Glycolipids are lipids
containing a fatty acid, sphingosine, and carbohydrate.
2. __________ are esters of fatty acids with higher molecular weight monohydric alcohols.
a.
b.
c.
d.
Fat
Waxes
Phospholipids
Glycolipids
Answer: B. Fat are esters of fatty acids with glycerol. Waxes are esters of fatty acids
with higher molecular weight monohydric alcohols. Phospholipids are lipids containing,
in addition to fatty acids and an alcohol, a phosphoric acid residue. Glycolipids are lipids
containing a fatty acid, sphingosine, and carbohydrate.
a. Fat
b. Waxes
c. Phospholipids
d. Glycolipids
Answer: D. Fat are esters of fatty acids with glycerol. Waxes are esters of fatty acids
with higher molecular weight monohydric alcohols. Phospholipids are lipids containing,
in addition to fatty acids and an alcohol, a phosphoric acid residue. Glycolipids are lipids
containing a fatty acid, sphingosine, and carbohydrate.
d. Aldolase
Answer: B
3. Which enzyme would synthesize D-Fructose 6-phosphate to D-Frustose 1,6
biphosphate?
a. Hexokinase
b. Phosphohexose isomerase
c. Phosphofructokinase
d. Aldolase
Answer: C
Chapter 19: Metabolism of Glycogen
1. ________ is known as protein primer
a. Glycogenin
b. Glycogen storage disease
c. Glycogen
d. Glycogen Synthase
Answer: A. Glycogenin is known as protein primer. Glycogen storage
diseases are a group of inherited disorders characterized by deficient
mobilization of glycogen or deposition of abnormal forms of glycogen.
Glycogen is the major storage carbohydrate in animals. Glycogen
synthase catalyzes the formation of a glycoside bond between C-1 of the
glucose of UDPGlc and C-4 of a terminal glucose residue of glycogen.
2. ________ are a group of inherited disorders characterized by deficient
mobilization of glycogen or deposition of abnormal forms of glycogen.
a. Glycogenin
b. Glycogen storage disease
c. Glycogen
d. Glycogen Synthase
Answer: B. Glycogenin is known as protein primer. Glycogen storage
diseases are a group of inherited disorders characterized by deficient
mobilization of glycogen or deposition of abnormal forms of glycogen.
Glycogen is the major storage carbohydrate in animals. Glycogen
synthase catalyzes the formation of a glycoside bond between C-1 of the
glucose of UDPGlc and C-4 of a terminal glucose residue of glycogen.
3. ________ is the major storage carbohydrate in animals.
a. Glycogenin
b. B. Glycogen storage disease
c. Glycogen
d. Glycogen Synthase
Answer: C. Glycogenin is known as protein primer. Glycogen storage
diseases are a group of inherited disorders characterized by deficient
mobilization of glycogen or deposition of abnormal forms of glycogen.