1.

a) Translate from Latin to English:

Praecipitatus
Conspergens
Talcum
Cortex
Horis alternis
Sub cutem
Ante usum agitator
Divide in doses aequales
Ad usum proprium
Da sub signo veneni

b). Excipient 1 is mixture of solid and liquid hydrocarbons.

Name of the mixture:__________________________________________________________
40 g of the excipient 1, 10 g of olive oil, 5 g of surface active agent, and 50 g of purified water
was mixed with technological procedure. Clotrimazole was incorporated to this dosage form
for treatment of fungal infection of the skin.
Name the dosage form:_______________________________________________________
Sub-group:

_________________________________________________________

i) Calculate HLB of used surface active agent, if you know M (lipophilic part) = 205, M
(hydrophilic part) = 1090 and M (total molecule) = 1295.

2.Compoun
d2

a. Chemical name :

_________________________________________________________

b. Purpose of this compound for saponification of glyceryl tristearate with NaOH:

___________________________________________________________________________
c. The purpose of compound 2 for preparation of aromatic water with peppermint:
___________________________________________________________________________
1

3.

a.Name the compound:

b.Which group of excipients this compound is in? Why?
c. Which dosage forms can this group of excipients are used in? What is their purpose in these
dosage forms? (Write at least three cases)

__________________________
__________________________
__________________________

___________________________
___________________________
___________________________

4. Please answer the next questions:

Rp
Morphini chloridi
0,010
Lactosi
ad
0,300
M. f. plv.
D. t. dos. No. XX (viginti)
D. S.: 1 powder in case of
pain
a. What is the form of the receipt: ______________
b. How we can divide these powders according to:

The place of application: ____________

division:__________________
compounds:_________________
c. The correct preparation of the powders we need to prepare triturate. Why?

d.We prepare triturate, which contains 5 % of active substance. For the preparation of 20 g of
triturate we need to weight ___________ g morphine chloride and ___________ g lactose.
e. For preparation of powders we need to weight ____________g triturate and ___________g
lactose.

f.Which rules do we need to use before and between mixing of the powders?

5. Please answer the next questions:

Rp
Menthol
Procaine
Benzocaine
Ethanol 50 %

7,5
3,0
3,0
ad
300

D. S.: grease to painful part of

the skin
We can prepare upper dosage using aethanolum dilutum and purified water. How much of
both do we need for the preparation?

How much will be the volume contraction?

6. Encircle the correct statements!

a. Refractive index is described by ratio between velocity of light in the vacuum (or air)
and velocity of light in investigated substance. T
b. The reflective index can be between 0 and 1. F (water 1,33)
c. The refractive index depends on the type of the substance, temperature and
wavelength. T
d. Refractive index can be used for investigation of the purity of the substance.
a.
b.
c.
d.

Suspensions are part of the solid perioral dosage forms.

The velocity of sedimentation is described by Stokeses equation. T
The velocity of sedimentation depends on density and size of the particles. T
Suspension of barium sulfate is used as purgative. F

a.
b.
c.
d.

Emulsions are colloid disperse systems liquid-liquid.

Bancroftovts rule describes the type of the prepared emulsion.
The size of the droplets in emulsion we can measure with the optical microscope.
The physical stability of the emulsion can be increased with addition of conservans.

7. Write the name of the container and its separate parts:

8. Write down 5 official dosage forms, which will be in the form of powders but from
different general monographs in Ph.Eur. 8.0 (krovnih monografij). Write down next to them
the required microbiological quality level.
Dosage form

microbiological quality level

1._______________________________________________________________________________
2._______________________________________________________________________________
3._______________________________________________________________________________
4. _______________________________________________________________________________
5._______________________________________________________________________________

9. Emulsions
i. Define emulsion and compounds needed for their preparation
ii. How do we divide them and what do we take into account in this
division?
iii. How do we prepare them?
iv. How do we characterise them?

10. Write down at least 5 dosage forms and the most often used pharmaceutical procedure for
their preparation

Dosage form___________________________Procedure_______________________
1._______________________________________________________________________________
2._______________________________________________________________________________
3._______________________________________________________________________________
4. _______________________________________________________________________________
5._______________________________________________________________________________