26/09/2015

NeriumBiotechnology,Inc.,SkinResearchOverview
HOME

ABOUT

RESEARCH

PRODUCTDEVELOPMENT

NEWS

CONTACT

SkinResearch
From historical/anecdotal use, continuing cancer and antiviral research with Nerium oleander extracts,

NBIResearch

Nerium Biotechnology, Inc. (NBI) has identified the potential for use of Nerium Ingredients in topical
skincare applications. NBIs proprietary technologies and product formulation provides for Nerium
Ingredients to be the key ingredient in each product that will be designed and formulated for a specific
target. This provides NBI with the opportunity to develop for the consumer an ever expanding series of
naturalbotanicalhealthcare,topical,cosmeticandOTCskinproducts.

Overview
ResearchPublications
CancerResearch
SkinCancerResearch

NewExtractionTechnology

AntiviralResearch
NBI has developed a new technology a patented process NBioPL (PlanttoPlant process) that
provides for the formulation of numerous new enhanced topical skincare products. This proprietary

SkinResearch

technologyincorporatespureliquidAloeVeraasthemediausedtoacquiretheuniqueNeriumoleander

FarmOperationsResearch

plant components in a way that preserves the unique and beneficial properties of both plants, without
additional solvents. The result of this process combines the unique beneficial properties of the Nerium

ImmuneResearch

oleander plant with the known beneficial properties of the Aloe Vera plant, providing the NAE8
ingredientfortopicalproductformulation.

HistoricalUse(Neriumoleanderplant)
HistoricaluseoftheNeriumoleanderplantformedicinalapplications
has been reported in ancient texts and folklore for more than 1500
years.TheNeriumoleanderplanthasbeenusedtraditionallyasfolk
remedies for a wide variety of maladies and conditions, including
dermatitis,eczema,psoriasis,herpes,sores,abscesses,warts,corns,
skin cancer, ringworm, scabies, epilepsy, asthma, malaria
dysmenorrheal,emetics,diureticsandhearttonics.

HistoricalUse(AloeVeraplant)
The Aloe Vera plant has been well known for centuries for its healing properties the raw plant and
commercialpreparationscanbeused,andbothoralintakeandtopicaldressingshavebeendocumented
tofacilitatehealingofanykindofskinwound,burn,orscaldevenspeedingrecoverytimeaftersurgery.
Historicaluseincludesblisters,insectbites,rashes,sores,herpes,urticaria,athlete'sfoot,fungus,vaginal
infections,conjunctivitis,sties,allergicreactions,anddryskin.Othertopicalusesincludeacne,sunburn,
frostbite (it appears to prevent decreased blood flow), shingles, screening out xray radiation, psoriasis,
preventingscarring,rosacea,warts,wrinklesfromaging,andeczema.

Top

Research
NBIhascontinuingindependentresearchfortopicalskinapplicationswiththepatentedNAE8ingredient
andNeriumADproducts.Thisresearchisbeingconductedatvariouscontractresearchfacilitiesandwell
known US academic institutions. With several publications in process, the data is peerreviewed and
publishedattheappropriatetime.

Publication
Antioxidant,antiinflammatory,antiapoptotic,andskinregenerativepropertiesofanAloeverabased
extractofNeriumoleanderleaves(NAE8)
DovePress05/02/15
KathleenFBenson,RobertANewman,GitteSJensen
NIS Labs, Klamath Falls, Oregon, USA University of Texas MD Anderson Cancer Center, Houston, TX,
USANeriumBiotechnology,Inc,SanAntonio,TX,USA

http://www.neriumbiotech.com/skin_research.htm

1/2

26/09/2015

NeriumBiotechnology,Inc.,SkinResearchOverview
Video abstract of original research paper Antioxidant, antiinflammatory, antiapoptotic, and skin
regenerativepropertiesofanAloeverabasedextractofNeriumoleanderleaves(NAE8)

3:22

SafetyandClinicalTesting
Research for NAE8 safety and clinical application was initiated with ST&T Research (Science,
Toxicology&Technology).ST&TResearchiscomprisedofagroupofprominentscientist,includingM.D.
and Ph.D. pharmacologists/toxicologist and research product development oriented physicians, scientist,
and regulatory compliance specialists which include a legal team specializing in US FDA/FTC/Customs
regulations. ST&T Research provides product development, product compliance, regulatory compliance,
clinicaltesting,andinformationanddataforsafetyandefficacy.
Dr.RobertA.NewmanasscientificadvisortoNBIprovidedassistancetoST&T.Withdatafromprevious
research studies, clinical trial experience, and utilization of validated analytical methods, Dr. Newman
assistedwithNAE8safetysupportandanalysis.
ST&TResearchinitiatedclinicalhumanstudies(4)forsafetywithtopicalapplicationofabasecreamwhich
included the NAE8 ingredient. The NBI topical test article application was first applied as a spot
treatment, then to increasingly larger areas of skin application with each new clinical study to evaluate
absorption. The studies included participants that exhibited various skin conditions to assist in the
evaluation of the absorption of the NBI topical test article with different skin conditions. A variety of
compromised/damaged/brokenskinconditionswerepresentedastheapplicationcoverageareaincreased
(agespots,actinickeratosis,acnevulgaris,sunburn,andfeverblisters/coldsores).Two(2)oftheseclinical
studiesincludedacomparisontowellknownOTCproductscurrentlyavailabletoconsumers.
Eachstudy'sprimaryendpointwastoevaluatetheNBItestarticlesforsafety/toxicity,a)Determineifthe
Neriumoleandermetaboliteswerebeingabsorbedthroughtheskin,b)Ifso,howmuch,c)Iftherewasany
noticeablebloodpressureorheartratechanges,andd)Iftherewerechangesinbloodchemistryororgan
systemfunctions.Inaddition,subjectswereobservedforinflammation,rash,ortendernesspossiblyrelated
tothecreamapplication.
ST&T Research utilized blood chemistry and CBC analysis whereby a comparison was made of the
participant's initial baseline results with additional measurements taken throughout the study. As an
example, participant blood samples were taken on day one (1) (one hour after cream application), day
seven(7),dayfifteen(15),andondaythirty(30)ofNAE8usetotestforabsorptionandaccumulation.
Analysis was noneventful. The analysis showed all subjects within normal ranges, there were no
detectable metabolites absorbed systemically and no adverse reactions noted. With regard to efficacy,
ST&Twassurprisedtofindtherewereastatisticallysignificantnumberofsubjectsreportingpositiveresults
sincetheNBItestarticlescontainedno"additivesorcleansingcompounds"liketheOTCproducts.
Investigators:Science,Toxicology&Technologyanditsphysicians/healthcarepractitioners.
Sponsor:NeriumBiotechnologyInc.(Nerium)

ProductClinicalTesting,withSafetyComponents
WithcompletionoftheseinitialNAE8safetytrials,continuingresearchandnewlyformulatedproducts
(NeriumADNightCream,NeriumADDayCream,etc.)haveproceededtoclinicaltrialsandtheconsumer
market. The clinical results of these trials have continued to demonstrate safety and the effective use of
theseproductsasatopicalapplicationfortheconsumer.

HOME|ABOUT|RESEARCH|PRODUCTDEVELOPMENT|NEWS|CONTACT

http://www.neriumbiotech.com/skin_research.htm

Copyright20112015NeriumBiotechnologyInc.

2/2