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Psych Obj 2015
Psych Obj 2015
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21. List the major side effects of the tricyclic antidepressants (TCAs)
and discuss the difference between tertiary amine TCAs and
secondary amine TCAs regarding these side effects.
22. Predict drug interactions of TCAs based on receptor mechanisms.
23. Describe the role of gut MAO and brain MAO in terms of tyraminerelated hypertensive crisis.
24. Compare fluoxetine and sertraline in terms of half-life and P450
2D6 interactions.
25. Discuss why SSRIs are thought to be safer than TCAs.
26. Discuss the similarities and differences of SSRIs and SNRIs.
27. Discuss the ways bupropion may be a different type of
antidepressant.
28. Describe the receptor influences of mirtazapine.
29. Describe trazodone's use as an antidepressant vs. its use as a
soporific.
30. Answer the study questions on the lecture handout.
31. A patient with a three-month history of major depression is started
on paroxetine. Three days later she calls reporting marked
improvement. What are some possible explanations of this and
how does this information influence your treatment plan?
32. The t1/2 of tranylcypromine (Parnatean MAO inhibitor) is about
2 hours. You have decided to stop this medication in order to start
a patient on another category of antidepressant. How long does it
take for this drug to no longer be detectable in plasma? Why is it
necessary to wait at least 10 days before starting the new
medication?
33. You have an elderly patient who has been successfully treated for
chronic depression with amitriptyline. (She has been on it without
difficulties for 20 years.) A neurologist starts this patient on
trihexyphenidyl (Artane), a medication used to treat Parkinsonism,
at a dose of 2 mg three times a day. What side effects would you
specifically watch for? If they appear, what do you do?
34. An elderly patient was only partially responsive to 125 mg of
imipramine, so the general practitioner lowered the dose to 100
mg and added 20 mg of fluoxetine. The next week the patient
returned confused, dizzy, and mildly agitated. In addition, his EKG
showed first-degree heart block. What happened? How could you
determine whether your hypothesis is correct and what would you
do?
35. To develop an understanding of concepts of developmental theory
(e.g., stages, critical periods, risk and protective factors).
36. To understand fundamental stages of cognitive development
according to Piaget.
37. To understand milestones in motor, sensory and language
development.
54. List three mood stabilizers and discuss their putative mechanisms
of action.
55. Compare the mechanisms of clearance and VOD of lithium vs. a
TCA (e.g., nortriptyline.)
56. Discuss the mechanisms underlying the interaction of lithium and
hydrochlorthiazide as well as lithium and a NSAID (non-steroidal
anti-inflammatory drug).
57. Describe the changes in steady state levels of carbamazepine
over the first 8 weeks of use.
58. Discuss the use of plasma level monitoring with regard to mood
stabilizers.
59. Discuss the problems of giving high dose aspirin to a patient on
valproate.
60. Answer the study questions on the handout.
61. Would regulating the lithium level be more difficult in a patient
with chronic renal failure or hepatic disease? Why?
62. Describe the effect of aging on T1/2, VOD, and clearance for
lithium.
63. A patient has treatment resistant mania and has failed lithium.
She partially responds to valproate alone and carbamazepine
alone. She does better on both together. What are the
pharmacokinetic effects of each drug on the other?
64. A young, female patient with mania is on birth control pills and
requires carbamazepine for treatment of her bipolar illness. What
are your concerns?
65. Describe diagnostic criteria for mania.
66. Describe diagnostic criteria for depression.
67. Describe the impact of Bipolar Disorder on mortality.
68. Features of psychosis. DDX
69. Mania. DDX
70. Depression. DDX
71. Common childhood disordersAttention Deficit Hyperactivity
Disorder (ADHD) and conduct disorder. DDX
72. Describe Familial Disorder.
73. Treatments (Lithium. Anticonvulsants. Antidepressants. ECT.
Antipsychotics. Psychotherapy.)
74. Alcohol use complications
75. Describe and define schizophrenia. (Ep, Etiol, PG, PP, Sx, PG)
76. Understand basic principles for diagnosis and management of
schizophrenia. (Criteria, DDX)
77. Compare the old generation and new generation antipsychotics in
terms of the dopaminergic and serotonergic systems.
78. List the differences in common side effects between the low
potency old generation antipsychotics and the high potency old
generation antipsychotics.