Classic Drug association in MRCP

DR.SHERIF BADRAWY

Dr. Sherif
Badrawy

Digitally signed by Dr.

Sherif Badrawy
DN: cn=Dr. Sherif Badrawy,
o=KKUH, ou=Critical Care,
email=sherif_badrawy@ya
hoo.com, c=SA
Date: 2015.03.23 10:45:36
+03'00'

Psychosis
1a

 levodopa
corticosteroids
1b

Increased risk of
venous
thromboembolism
2a

 combined oral
contraceptive pill
tamoxifen
antipsychotics
2b

increased risk of
endometrial cancer
3a

Tamoxifen
3b

Flushing
4a

 amlodipine
sildenafil
tamoxifen
4b

Mucositis
5a

 methotrexate
fluorouracil (5-FU)
5b

Fluid retention
6a

 pioglitazone
ciclosporin
corticosteroids
hydralazine
6b

Peripheral
neuropathy
7a


vincristine,vinblastine,cisplatin
isoniazid
amiodarone
phenytoin
etanercept

7b

haemorrhagic cystitis
8a

Cyclophosphamide
8b

Carbimazole
9a

myelosuppression/agranulocytosis

9b

Primaquine
10a

haemolysis in
patients with G6PD
deficiency
10b

Toxicity in patients
with thiopurine
methyltransferase
deficiency
11a

azathioprine
11b

Thrombocytopaenia
12a

 heparin
sodium valproate
thiazides
valproic acid
quinidine
12b

antagonist of the
P2Y12 adenosine
diphosphate (ADP)
receptor
13a

Clopidogrel
13b

acetazolamide
14a

Normal anion gap

metabolic acidosis
14b

Sumatriptan contraindicated by:

15a

ischaemic heart
disease
15b

tendon damage
16a

Ciprofloxacin
16b

acts as a decoy
receptor for TNFalpha
17a

Etanercept
17b

Prevents microtubule
depolymerisation &
disassembly,
decreasing free tubulin
18a

docetaxel
18b

Inhibits formation of
microtubules
19a

vincristine
19b

Intracranial
hypertension
20a

 isotretinoin
corticosteroids

20b

Pulmonary,
retroperitoneal and
cardiac fibrosis
21a

bromocriptine
21b

glucagon-like
peptide-1 mimetic
22a

Exenatide
22b

increased risk of
fractures
23a

 Pioglitazone
heparin
bisphosphonates
corticosteroids
23b

Adenosine contraindicated by:

24a

asthma
24b

Weight gain
25a

 sodium valproate
sulfonylureas
pioglitazone
lithium
antipsychotics
corticosteroids

25b

decreases IL-2
release by inhibiting
calcineurin
26a

Ciclosporin 26b

Causes cross-linking
in DNA
27a

cisplatin
27b

Oculogyric crisis
28a

 antipsychotics
metoclopramide
28b

Metformin
Monitoring
29a

review if creatinine is
> 130, stop
metformin if > 150
29b

ACE inhibitors
Monitoring
30a

Acceptable in serum
creatinine , up to 50% from
baseline or up to 265
(whichever is smaller) & an
increase in potassium up to 5.5
30b

oesophagitis
31a

Bisphosphonates
31b

liver fibrosis
32a

Methotrexate
32b

5-HT3 antagonist
33a

Ondansetron 33b

Increased risk of
ischaemic stroke
34a

 combined oral
contraceptive pill
antipsychotics
34b

Hypomagnesaemia
35a

cisplatin
35b

torticollis
36a

Antipsychotics
36b

slate-grey appearance
37a

Amiodarone
37b

Anal ulceration
38a

nicorandil
38b

Increased risk of
cervical cancer
39a

combined oral contraceptive pill

39b

Sildenafil contraindicated by:

40a

recent myocardial
infarction
40b

Aspirin in
breastfeeding
41a

must be avoided
41b

Corneal deposits
42a

 amiodarone
antipsychotics
42b

irreversible blockade
of H+/K+ ATPase
43a

Omeprazole 43b

Metformin contraindicated by:

44a

recent myocardial
infarction
44b

Palpitations
45a

 levodopa
hydralazine
adenosine
45b

Akathisia (severe
restlessness)
46a

antipsychotics
46b

Red man syndrome

47a

vancomycin
47b

Epistaxis
48a

 isotretinoin (dt
dryness)
warfarin
48b

Reactivation of
tuberculosis
49a

 corticosteroids
infliximab
etanercept
49b

recombinant version
of urate oxidase
50a

Rasburicase 50b

Depression
51a

 isotretinoin
corticosteroids
levodopa
51b

Hypertrichosis
52a

 ciclosporin
minoxidil
52b

Cinchonism
53a

quinidine
53b

Thrombophlebitis
54a

 amiodarone
vancomycin
54b

Impotence
55a

thiazides
beta-blockers
55b

Pruritus
56a

 opioids
fenofibrate
56b

Hypocalcaemia
57a

 loop diuretics
foscarnet
57b

Skin necrosis
58a

warfarin
58b

anticoagulant which
don't cross-react
HIT Abs
59a

 Danaparoid
Lepirudin
Argatroban
59b

Oligospermia
60a

sulphasalazine
60b

urinary retention
61a

 Tricyclic
antidepressants
antipsychotics
chlorpheniramine
61b

Proximal myopathy
62a

corticosteroids
62b

Hypothyroidism
63a

 amiodarone
lithium
carbimazole
63b

Blocks T-type calcium

channels in thalamic
neurons
64a

ethosuximide
64b

Binds to TNF-alpha
and prevents it from
binding with TNF
receptors
65a

infliximab
65b

Anti-CD20
monoclonal antibody
66a

rituximab
66b

Decreases absorption
of fat-soluble
vitamins
67a

cholestyramine
67b

Osteoporosis
68a

 corticosteroids
heparin
pioglitazone
68b

Mania
69a

corticosteroids
69b

Competitive
antagonist of nicotinic
acetylcholine
receptors
70a

atracurium
70b

Myalgia
71a

 statins
fenofibrate
71b

Dopamine receptor
agonist
72a

 ropinirole
apomorphine
bromocriptine
cabergoline
72b

Acetylcholinesterase
inhibitor
73a

 donepezil
pyridostigmine
galantamine
rivastigmine
edrophonium
73b

inhibits RANK ligand,

which in turn inhibits
the maturation of
osteoclasts
74a

Denosumab 74b

Insomnia
75a

corticosteroids
75b

Tachycardia
76a

 isosorbide
mononitrate
hydralazine
minoxidil
76b

Neuroleptic
malignant syndrome
77a

antipsychotics
77b

Anorexia
78a

 levodopa
digoxin
interferon-alpha
78b

Optic neuritis
79a

ethambutol
79b

Non-arteritic anterior
ischaemic neuropathy
80a

sildenafil
80b

coarsening of facial
features
81a

Phenytoin
81b

Pneumonitis
82a

 amiodarone
methotrexate
82b

Bronchospasm
83a

 beta-blockers
adenosine
83b

Hypertension
84a

 corticosteroids
ciclosporin
84b

Inhibits microtubule
polymerization by binding to
tubulin, interfering with
mitosis. Also inhibits
neutrophil motility and activity
85a

colchicine
85b

Metabolised to the active

compound
mercaptopurine, a purine
analogue that inhibits
purine synthesis
86a

azathioprine
86b

potassium-channel
activator
87a

Nicorandil 87b

bivalirudin
88a

Reversible direct
thrombin inhibitor
88b

Activates antithrombin
III. Forms a complex that
inhibits thrombin, factors
Xa, Ixa, Xia and XIIa
89a

unfractionated
heparin
89b

Bladder cancer
90a

pioglitazone
90b

Suppression of
growth in children
91a

corticosteroids
91b

Steven-Johnson
syndrome
92a

 lamotrigine
carbamazepine
92b

Increased risk of
breast cancer
93a

combined oral contraceptive pill

93b

MAO-B inhibitor
94a

selegiline
94b

COMT inhibitor
95a

 entacapone
tolcapone
95b

Inhibits sodium
absorption at the
beginning of the distal
convoluted tubule
96a

bendroflumethiazide
96b

Blocks the action of

cyclooxygenase-1 and
2 and thromboxane
A2 formation
97a

aspirin
97b

Hyperprolactinaemia
98a

 antipsychotics
metoclopramide
98b

Enhance the effect of the

inhibitory
neurotransmitter gammaaminobutyric acid (GABA)
99a

benzodiazepines
99b

Alopecia
100a

 sodium valproate
valproic acid
100b

Increased risk of
myocardial infarction
101a

combined oral contraceptive pill

101b

Constipation
102a

 antipsychotics
verapamil
tricyclic antidepressants
opioids
102b

Apomorphine
103a

dopamine receptor
agonist
103b

Retinopathy
104a

hydroxychloroquine
104b

Slurred speech
105a

 antipsychotics
phenytoin
amantadine
105b

Gout
106a

 thiazides
pyrazinamide
loop diuretics
nicotinic acid
106b

Blurred vision
107a

 antipsychotics
tricyclic antidepressants
ivabradine
chlorpheniramine
107b

Gingival hyperplasia
108a

 phenytoin
ciclosporin
amlodipine
diltiazem
verapamil
108b

Dyskinesia
109a

 levodopa
antipsychotics
phenytoin
109b

Photosensitivity
110a

 amiodarone
tetracyclines
isotretinoin
thiazides
110b

Nasal congestion
111a

sildenafil
111b

Ototoxicity
112a

 loop diuretics
aminoglycosides
vancomycin
112b

Ataxia
113a

 phenytoin
sodium valproate
carbamazepine
amantadine
113b

Dry mouth
114a

 isotretinoin
tricyclic antidepressants
levodopa
antipsychotics
chlorpheniramine
114b

Hypoglycaemia
115a

 sulfonylureas
meglitinides
115b

Heart failure
116a

 verapamil
diltiazem
116b

Dry skin
117a

isotretinoin
117b

Cartilage damage
118a

ciprofloxacin
118b

pyrimidine analogue which

induces cell cycle arrest
and apoptosis by blocking
thymidylate synthase
119a

Fluorouracil (5-FU) 119b

discolouration of
teeth
120a

Tetracyclines
120b

Osteonecrosis of the
jaw
121a

bisphosphonates
121b

Blocks the release of

acetylcholine
122a

Botox
122b

Heart block
123a

 verapamil
diltiazem
ivabradine
adenosine
digoxin
123b

Hirsutism
124a

 phenytoin
corticosteroids
124b

growth hormone
receptor antagonist
125a

Pegvisomant 125b

agonist of the A1
receptor in the AV
node
126a

Adenosine 126b

Hypokalaemia
127a

 thiazides
loop diuretics
amphotericin B
127b

Stimulates alpha
adrenergic, dopaminergic
and serotonergic receptors
resulting in uterine
contractions
128a

ergometrine
128b

Blocks the uptake of

dopamine,
noradrenaline and
serotonin
129a

cocaine
129b

Crystalline
nephropathy
130a

aciclovir
130b

Confusion
131a

 digoxin
amantadine
phenytoin
metoclopramide
131b

Haemolysis in
patients with G6PD
deficiency
132a

 primaquine
ciprofloxacin
sulphonamides
sulphasalazine
sulfonylureas
132b

Meglitinides MOA
133a

increase pancreatic
insulin secretion
133b

non-specific
phosphodiesterase
inhibitor and decreases
cellular uptake of
adenosine
134a

Dipyridamole 134b

Pancreatitis
135a

 corticosteroids
sodium valproate
thiazides
valproic acid
135b

Facilitate GABAA
action by increasing the
duration of chloride
channel opening
136a

barbiturates
136b

Yellow-green vision
137a

digoxin
137b

Arachidonic acid product

causing vasoconstriction &
increased platelet
aggregation
138a

TXA2
138b

Lymphadenopathy
139a

phenytoin
139b

Tremor
140a

 lithium
ciclosporin
sodium valproate
antipsychotics
140b

Sumatriptan contraindicated by:

141a

cerebrovascular
disease
141b

Inhibits GABA
transaminase
142a

valproic acid
142b

Increased
susceptibility to
severe infection
143a

 corticosteroids
ciclosporin
143b

Hyponatraemia
144a

 thiazides
loop diuretics
sulfonylureas
carbamazepine
sodium valproate
144b

Non-specific inhibitor
of phosphodiesterase
resulting in an increase
in cAMP
145a

theophylline
145b

Increases cGMP
leading to smooth
muscle relaxation
146a

 isosorbide
mononitrate
hydralazine
146b

Antagonises the
effects of vitamin K
147a

warfarin
147b

Gynaecomastia
148a

spironolactone
148b

Drug-induced lupus
149a

 hydralazine
procainamide
hydralazine
phenytoin
carbamazepine
tetracyclines
isoniazid

149b

Disulfiram-like
reaction with alcohol
150a

metronidazole
150b

Nephrotoxicity
151a

 ciclosporin
aminoglycosides
amphotericin B
foscarnet
vancomycin
loop diuretics

151b

HER2/neu receptor
antagonist
152a

trastuzumab
152b

Respiratory
depression
153a

 benzodiazepines
opioids
153b

Reduced seizure
threshold
154a

 ciprofloxacin
antipsychotics
foscarnet
154b

Dizziness
155a

 phenytoin
carbamazepine
amantadine
nicorandil
155b

Hyperlipidaemia
156a

 isotretinoin
corticosteroids
ciclosporin
protease inhibitors
antipsychotics
156b

Lipodystrophy
157a

 protease inhibitors
corticosteroids
157b

Cholesterol gallstones
158a

 cholestyramine
fenofibrate
158b

Bradycardia
159a

 amiodarone
beta-blockers
digoxin
verapamil
diltiazem
ivabradine

159b