PATHOPHYSIOLOGY OF CAD- NSTEMI 2nd to CKD

MODIFIABLE FACTORS
 Diabetes mellitus with
or without insulin
resistance NON MODIFIABLE FACTORS
 Cigarette smoking  Age 45 years old and
 Hypercholesterolemia = above
increased LDL levels  Gender : male
and decreased HDL  Familial History of heart
 Increase blood pressure diseases
 Obesity = BMI greater
than 30kg/m
 Stressors
 Alcohol use
 Sedentary lifestyle

Disrupted atherosclerotic
plaque at coronary artery

Total occlusion of artery

due to atherosclerosis

Plaques become unstable

and moves

Thrombus formation which

occludes the artery

Plaque ruptures at the

coronary blood vessels
 MYOCARDIAL INFARCTION

Impaired blood flow to the heart

creating an imbalance in myocardial
oxygen supply and demand FINDINGS in the
DIAGNOSTIC EXAMS

 Troponin level =
ISCHEMIA detectable 3-
6hours post MI

S/SX: Cellular injury  Increased CKMB

*Chest pain –
heaviness or
 Increased
tightness myoglobin levels
*heatburn Occlusion of heart cells wherein C.A.
with nausea
dies causing CELL DEATH  ECG results
and vomiting
*persistent o ST and T
shortness of
breath wave
*weakness abnormalit
and dizziness y