Patients Name:

Aida Paco

Age:

57 years old
Female

Diagnosis:

AUB-M, Endometrioid Carcinoma

Sex:

Physician:

Dr. Laplana, Charlene

Date of Admission:

Name of Drug
Generic Name: cefuroxime

Classification
Pharmacologic Class:
nd

November 10, 2015

Mechanism of Action

Indication

Chemical:

General Indication:

Trade/Brand Name: Ceftin, Zinacef

2 -generation cephalosporins

Bind to bacterial cell wall membrane, causing cell

Meningitis

Patients Dose: 500 mg TID PO

Therapeutic:

death

Gynecologic Infections

Maximum Dose: 750 mg

Anti-infectives

Therapeutic:

Lyme disease

Minimum Dose: 125 mg

Pregnancy Risk Category:

Bactericidal action against susceptible bacteria.

Contents: Cefuroxime sodium/

Category B

Active against Borrelia burgdorferi

Cefuroxime axetil

Source:

Pharmacokinetics:

Availability:

Daviss Drug Guide for Nurses p.295

Absorption: well absorbed following oral and IM

Patients Indication:

Tablets: 125, 250 and 500

administration

Gynecologic Infection

mg.

Distribution: widely distributed. Penetration into

Powder for Oral Suspension:

CSF is adequate. Crosses placenta and enter

125 or 250 mg per 5 ml

breast milk in low concentrations

(teaspoon).

Metabolism: metabolized by the liver

Injection: 750 mg, 1.5 g and

Elimination: excreted by the kidneys

Route: 7.5 g.Onset:

PO

unknown

Peak:
2-3 hr

Duration:
8-12 hr

IM
15-60
Route(s) ofRapid
Administration:
PO, IV, 6-12 hr
min
IM
IV
rapid
End of
Source: Daviss Drug Guide for
infusion
Nurses p.295

6-12 hr

Drug Half-Life: 60-120 min

Source:

Source

Daviss Drug Guide for Nurses p.295

Daviss Drug Guide for Nurses

p.295

Height:

5 ft

Weight:

45 kg
Contraindication

Side Effects

Nursing Responsibilities
Before:

Contraindication:
Hypersensitivity to cephalosporins

CNS Seizures (High doses)

Observe the 10Rs of drug administration

Serious hypersensitivity to penicillins

GI Pseudomembranous Colitis, diarrhea,

Ask for drug allergies

Precautions:

cramps, nausea, vomiting

Administer the prescribed dosage

Renal impairment
Dose adjustment due to age-related

Derm rashes, urticarial

Assess for infection

Hemat - agranulocytosis, bleeding,

Dont confuse cefuroxime with cefotaxime

decrease in renal function may be

eosinophilia, haemolytic anemia, neutropenia,

necessary
May also increase risk for bleeding

thrombocytopenia

Drug Interactions:

Probenecid decrease excretion and

increase blood levels

Aminoglycosides/Loop diuretics may

Local pain at IM site, phlebitis at IV site

Daviss Drug Guide for Nurses p.295

Tablet may be taken without regard to meals

Observe patient for signs and symptoms of anaphylaxis
Tell patient to swallow the whole tablet (Crushing the tablet

will have persistent bitter taste.)

Administer around the clock at evenly spaced times
Finish the medication completely, even if feeling better

Misc allergic reactions including anaphylaxis

and serum sickness, super infection

After:

increase risk of nephrotoxicity

Source:

During:

Source:
Daviss Drug Guide for Nurses p.295

Advise patient to report signs of any adverse reactions

Instruct patient to notify health care professional if fever or

diarrhea develop
Instruct patient to notify if stool contains blood, pus, or mucus
Advise patient not to treat diarrhea without consulting health

care professional
Documentation

Source:

Daviss Drug Guide for Nurses p.297-300