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Abdominal Tuberculosis
Abdominal Tuberculosis
DEFINITION
Abdominal tuberculosis includes TB of gastro-intestinal tract, peritoneum, omentum,
mesentery, lymph nodes and other solid intra-abdominal organs like liver, pancreas and
spleen.
EPIDEMIOLOGY
Abdominal tuberculosis is one of the most common forms of extra-pulmonary TB (1). TB
peritonitis constitutes 4-10% of all patients with extra pulmonary TB (1). Incidences of
isolated intestinal Tb in unselected autopsy series from India has been reported to vary from
0.02-5.1% (2). In Delhi 0.8% of all hospital admissions were reported to be due to intestinal
TB (3). In India, Tb has been reported to be the cause in 3-5% of patients with intestinal
obstruction (4). About 5-7% of all gastro-intestinal perforations (excluding appendix
perforations) have been reported to be due to TB (5).
CLASSIFICATION OF ABDOMINAL TUBERCULOSIS
1. Gastro-intestinal
Ulcerative
Hypertrophic or hyperplastic
Sclerotic or fibrous
Diffuse colitis
2. Peritoneal
Acute TB peritonitis
Chronic peritoneal tuberculosis
Ascitic form
Encysted or loculated form
Fibrous form (adhesive/ plastic type)
3. Mesentery and its contents
Mesenteric adenitis
Mesenteric cyst
Mesenteric abscess
Bowel adhesions
Rolled-up omentum
4. Solid viscera
Liver, biliary tract & gall bladder, pancreas and spleen
5. Retroperitoneal lymph node TB etc.
MICROBIOLOGY
dull aching, especially when the peritoneum and mesenteric lymph nodes are involved and
colicky in case of intestinal obstruction.
Diarrhoea occurs in 11-20% of the patients (1,6). Liquid to semisolid stools are passed 6-8
times a day. Mucus is usually present. Blood or frank pus may be passed rarely. Diarrhoea is
almost always associated with intestinal ulceration, although it can sometimes occur in the
absence of any mucosal disease and is thought to occur due to generalized inflammatory
response. In primary small bowel disease the stools are large in amount, foul smelling and
resemble those seen in malabsorption. Diarrhoea alternating with constipation has been
described in 8.8-20% of patients (1,6).
Other symptoms include flatulence, nausea, altered bowel habit and borbrygmi. Abdominal
distension suggests ascites or persistent subacute intestinal obstruction. Typical duodenal
ulcer like pain may occur when the duodenum is involved.
Physical examination
Patients with chronic abdominal tuberculosis are often malnourished and anaemic. In some
the abdomen may be completely normal on examination, but most demonstrate some
abnormal findings. There may be visible peristalsis and the distended bowel loops can be
palpated. The abdomen may be distended or the signs may be more localized, usually in the
right lower quadrant. An ileocaecal mass may be felt in the right ileac fossa or higher up in
the right lumbar region. A doughy abdomen suggesting peritoneal disease has become less
common in recent years. A rolled up omentum when present, is felt as transversely placed
mass in the epigastric region. Loculated ascites, mesenteric cysts and mesenteric abscesses
present as cystic masses.
Patients with ascites may have shifting dullness and a fluid thrill. In patients with large bowel
disease a diffusely thickened and tender colon may be felt. Other findings include
hepatosplenomegaly, pelvic abnormalities mimicking gynaecological tumours and the
features of gastric outlet obstruction due to direct involvement of stomach or extrinsic
compression of duodenum by enlarged mesenteric lymph nodes. Rectal examination may
reveal any fistulae, fissures or stricture.
COMPLICATIONS
Mal absorption
Intestinal obstruction
Perforation peritonitis
Acute bleeding from rectum or hemetemesis
Fistulas ( entero-enteric, entero-vesical, enero-cutaneous) etc.
DIAGNOSIS
Since the discovery of tubercle bacilli it has been possible to make a precise diagnosis of
tuberculosis. However, in patients with abdominal tuberculosis the causative organism often
difficult to identify and the diagnosis is generally made by the indirect methods.
1) Haematology and serum biochemistry
Laboratory investigations are nonspecific and do not contribute to the diagnosis. There is a
varying degree of anaemia, leucopenia with relative lymphocytosis. Raised erythrocyte
sedimentation rate (ESR) is reported in 50-100% of patients (1,6). However, ESR was found
to be normal in many histologically proven patients with abdominal TB (1,6). Serum albumin
levels tend to be depressed. Serum alkaline phosphatase may be raised (1,6).
2) Tuberculin skin test
A positive skin test has been reported in 55-100% of patients of abdominal TB (1,6).
However, positive skin test neither confirms nor excludes abdominal TB in areas where TB is
highly endemic and in those who have received BCG vaccine because of high rates of
positivity in healthy individuals.
3) Ascitic fluid analysis
Ascitic fluid leucocytes count is usually 150 4000 cells / mm 3 and consists of lymphocytes
predominantly. For unknown reasons, neutrophilic response has been observed in patients
with TB peritonitis associated with peritoneal dialysis (9). Red blood cells may be found
often in the ascitic fluid.
The serum-ascitic fluid albumin gradient is less than 1.1 in more than 90% of patients (1).
Ascitic fluid reveals AFB in less than 3% of cases and culture for Mycobacterium
tuberculosis is positive in less than 20% of cases (1).
4) Adenosine deaminase ( ADA)
Adenosine deaminase (also known as ADA) is an enzyme involved in purine metabolism. It
is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in
tissues. There are 2 isoforms of ADA: ADA1 and ADA2. ADA1 is found in most body cells,
particularly lymphocytes and macrophages, ADA2 was first identified in human spleen. It
was subsequently found in other tissues including the macrophage where it co-exists with
ADA1. ADA is involved in the proliferation and differentiation of lymphocytes, especially T
lymphocytes; hence, it is a marker of cell mediated immunity (type 4 hypersensitivity
reaction).
When a cut-off value of 32 IU / litre is chosen, the sensitivity and specificity of ascitic fluid
ADA are found to be 98% and 95% respectively ( 10). False negative results are seen in
cirrhosis of liver and HIV infection and false positive results are seen in malignant ascitis.
Interferon ( IFN- ) which is significantly higher in TB ascitis can be used to differentiate
TB ascitis from non-TB ascits.
5) Serodiagnosis
The serum CA-125 level that is normally elevated in ovarian malignancy is also raised in
some patients with abdominal TB. The level falls with anti-tuberculous treatment.
6) Polymerase chain reaction
The technique has been used in a variety of clinical specimens including sputum, CSF,
pleural and peritoneal fluids and biopsy tissues with sensitivity, specificity and positive
predictive value of 85%, 99% and 95% respectively.
7) Imaging studies
Chest x-ray
Associated pulmonary TB has been described in 24-28% of patients with abdominal TB.
X ray abdomen
Features like calcified lymph nodes, calcified granuloma in solid organs, dilated bowel loops,
air-fluid levels and free gas under diaphragm may be found in abdominal TB.
Barium studies
Barium studies have been the most useful investigation for the diagnosis of intestinal TB till
recently. Although the radiological features of intestinal TB are non-specific, several findings
are highly suggestive of disease. Enteroclysis (small bowel enema) followed by barium
enema is useful for evaluation of intestinal TB.
Features of intestinal TB in barium meal follow through (BMFT)
Hyper segmentation ( Stierlins sign) & flocculation of barium because of extreme
irritability due to mucosal ulceration there will be a rapid transit and lack of barium
retention in the inflamed segment of the small bowel one of the earliest signs.
Contractecd and pulled-up caecum
Mucosal ulceration ulcers may be linear or stellate and are situated along the
circumference of the wall.
Irregular thickened mucosal folds
Inverted umbrella sign (Fleischners sign) thickening of ileoceacal valve which
gives a broad triangular appearance with the base towards the caecum.
Stenosis or string sign
Dilated bowel loops
Both Stierlins sign and string sign are also seen in Crohns disease and hence not specific for
intestinal TB.
Oesophageal TB Barium swallow
Ulcers
Stricture
Pseudo tumour
Sinus / fistulae
Traction diverticulae
Abdominal ultrasonography
Abdominal ultrasound often reveals a mass made up of matted loops of small bowel with
thickened walls, diseased omentum, mesentery and loculated ascitis (11). Ultrasound is very
sensitive in detecting small quantities of ascitic fluid. Fine septae may be seen in ascitic
fluid, which are considered to be diagnostic of abdominal Tb (11). These strands are usually
arise from the serosa of small bowel and may be observed in malignant ascitis also (12).
Loculated ascitis probably represents walled-off peritoneal inflammation. Interloop ascitis
gives rise to characteristic club sandwich appearance of alternating echogenic and echo-free
layers of bowel wall and inter loop fluid (13).
Mesenteric thickening is better detected in presence of ascitis and is often seen as the stellate
sign of bowel loops radiating out from its root. Enteritis with bowel wall thickening which is
usually uniform and concentric as opposed to eccentric thickening at the mesenteric border
seen in the Crohns disease and the variegated appearance seen in malignancy. This may be
difficult to appreciate on ultrasonography. Lymphoma of the bowel remains an important
differential diagnosis. Lymphadenopathy which may be discrete or matted particularly in
periportal, peripancreatic and mesenteric region is seen. Calcification, heterogenous
echotexture and necrosis may also be identified in lymphadenopathy.
CECT abdomen
Similar findings as noted on ultrasound, but with better resolution and definition are seen
with the CT scan. The ascitic fluid , thickening and nodularity of peritoneum and mesentery
can be more easily identified on CT scan. Other findings include - lymphadenopathy,
thickened bowel loops, granulomas or abscess in the liver, pancreas and spleen may be seen.
8) Endoscopy
Fibre optic endoscopes have made it possible to visualize directly the gastrointestinal tract.
Colonoscopy is the easiest and most direct method of establishing the diagnosis of TB colitis.
On colonoscopy, the ileocaecal valve may be oedematous or deformed. Other findings may
be, mucosal ulceration, nodules, pseudopolyps, narrowing and stricture of the bowel. Rarely,
there may be diffuse disease of the colon with hyperaemia and friability of mucosa
mimicking ulcerative colitis.
However, as with most diagnostic procedures in intestinal TB, endoscopic findings are not
pathognomonic. The endoscopic findings can be mistaken for Crohns disease. In TB
intestine, ulcers are usually transverse, have sharply defined margins with erythema of
surrounding mucosa. Fibrosis is common with short stricture (<3cms). In Crohns disease
ulcers are serpiginous, often longitudinal, with relatively normal surrounding mucosa.
Endoscopic biopsy specimens show granulomas and epitheloid cells in 40-74% of patients,
caseous necrosis in 8-21% cases and positive cultures in 6-40% of patients with intestinal TB.
A combination of histology and culture of the biopsy specimen can establish the diagnosis in
80% of cases (14). Endoscopy is also useful in excluding other conditions such as carcinoma,
lymphoma and caecal amoeboma.
9) Fine needle aspiration cytology ( FNAC)
In patients with palpable masses, FNAC has been shown to have a high diagnostic accuracy
(15). In patients with lymphadenopathy, abscesses and focal lesions of viscera, FNAC
confirms the diagnosis (16). Lowenstein-Jensen culture of the FNAC material increases the
yield further. The FNAC during colonoscopy s likely to add to the diagnostic yield in patients
with ileocaecal or clonoic TB (15).
10) Laparoscopy
Direct inspection and biopsy of the peritoneum are perhaps the most effective method of
diagnosing TB peritonitis. Characteristic laparoscopic findings include multiple, yellowishwhite military nodules over visceral and parietal peritoneum; erythematous, thickened and
hyperaemic peritoneum; turbid ascitis and adhesions. Laparoscopy alone will facilitate an
accurate presumptive diagnosis in 80-95% of patients (1). Laparoscopic biopsy may reveal
AFB in 75% and caseating granulomas in 85-90% 0f patients (1)
TREATMENT
The treatment of abdominal tuberculosis is primarily medical. Since acid-fast bacilli and
caseation necrosis are seen in minority of patients and culture takes several weeks, empirical
anti tuberculous therapy should be initiated in every patient with suspected tuberculosis.
Earlier, patients with abdominal TB have been treated with antituberculous drug regimens of
8-12 months duration (17). However, recent evidence suggest that six months short course
chemotherapy regimens are effective in all forms of abdominal TB (18). In India, majority of
patients with abdominal TB get treated with DOTS using standardized intermittent treatment
regimens under RNTCP of Govt.of India.
Drug dosage
Daily dosage
Intermittent dosage
( thrice weekly)
Drugs
mg /
kg
Dosage (mg)
mg / kg
Dosage (mg)
Rifampicin (R)
10
600 (450)
10
600 (450)
Isoniazid (H)
300
10
600
Pyrazinamide (Z)
20-30
1.5-2.0 g
(1.0-1.5 g)
30-40
2.0-2.5 g
(1.5-2.0 g)
Ethambutol (E)
15
Streptomycin (S)
12-15
30
750 ( 500750)
12-15
750 (500-750)
Figures in paracentesis indicate drug dosage in patients with weight < 50 kgs.
Dosage schedule
Total duration is 6 months
Initial 2 months is intensive phase followed by 4 months of continuation phase
Rifampicin, isoniazid and pyrazinamide are used in the intensive phase. A fourth drug
ethambutol or streptomycin is added if drug resistance rate is more than 4%
Rifampicin and isoniazid are used in the continuation phase
It is advisable to administer pyridoxine hydrochloride (5-10 mg) to all patients to
prevent isoniazid induced peripheral neuropathy.
Response to treatment
The clinical response to treatment is excellent. Systemic symptoms such as fever, malaise and
weight loss subside in a few weeks. Mucosal abnormalities take longer and barium studies
and endoscopy demonstrate regression of the lesions in most individuals. The majority of
patients (approx. 70%) with subacute intestinal obstruction and evidence of intestinal stricture
show complete resolution of radiological abnormality.
ROLE OF SURGERY
Indications
Surgical options
Stricturoplasty
Resection of the diseased segment with end to end anstomosis
Limited ileocaecal resection with a five cms margin from visibly abnormal tissue or
limited right hemicolectomy and endto-end a anastomosis for hypertrophic
ileocaecal TB (19).
REFERENCES
1.Marshall JB. Tuberculosis of gastro-intestinal tract and peritoneum. Am J Gastroenterol
1993;88:989-99
2.Tribedi BD, Gupta DM. Intestinal tuberculosis in Bengal. J Indian med Assoc 1941;11:41
3.Chuttani HK. Intestinal Tuberculosis. In: Card WI, Creamer B, editors. Modern trends in
gastroenterology. London: Butterworth; 1970. P.309-27
4.Bhansali SK,Sethna JR.Intestinal obstruction:A clinical analtsis of 348 cases.Indian JSurg
1970;32:57-70
5.Bhansali SK.Gastrointestinal perforations;Clinical study of 96 cases.J postgrad
Med1967;13:1-12
6. Pimparker B D Donde U M. Intestinal tuberculosis.I.clinical and radiological studies.J
Assoc physicians india 1974;22:205-18.
7. Fujimura Y.Functional morphology of microfold cells[M cells] in peyers patchesphagocytosis and transport of BCG by M cells into rabbit peyers patches. Gastroenterol
Jpn1986;21:325-35
8.Tandon HD,Prakash A. Pathology of intestinal tuberculosis and its distension from crohns
disease. Gut 1972:13:260-9