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Gout Evidence Based Medicine
Gout Evidence Based Medicine
In the case of Mr RG, he was given an NSAID for his pain with prednisolone 30mg
orally. This is appropriate in the context of the available evidence. There is
currently no reliable trial data comparing the use of NSAIDs/corticosteroids and
colchicine. In clinical practice it remains that there is relative freedom in the
choice of anti-inflammatory medications for acute gout. With similar efficacy
between the three choices it is usual practice to delay more toxic medications
(colchicine) after others have proven inadequate. Care must also be taken in
considering the patients co-morbidities in choosing the most appropriate
therapy.
References
Khanna, P & FitzGerald, J 2015, Evolution of management of gout: a comparison
of recent guidelines, Current Opinion Rheumatology, vol. 24, no. 2, pg. 139146.
Khanna, P, Gladue, H, Singh, M, FitzGerald, J, Bae, S, Prakash, S, Kaldas, M,
Gogia, M, Berrocal, V, Townsend, W, Terkeltaub, R & Khanna, D 2014, Treatment
of acute gout: a systematic review, Seminars in Arthritis and Rheumatism, vol.
44, no. 1, pg. 31-38.
Terkeltaub, R, Furst, D, Bennett, K, Kook, K, Crockett, R & Davis, M 2010, High
versus low dosing of oral colchicine for early acute gout flare: Twenty-fourhour
outcome of the first multicenter, randomized, double-blind, placebo-controlled,
parallel-group, dose-comparison colchicine study, Arthritis & Rheumatism, vol.
62. no. 4, pg. 1060-1068.
Turner, J & Cooper, D 2015, Does colchicine improve pain in acute gout flare?,
Annals of Emergency Medicine, Published 24 April 2015.