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Dosis Ranitidin k10
Dosis Ranitidin k10
yearswerefittedwithParapermoxygenpluscontactlensesandwerecomparedwith20spectacle
wearers.Theaverageprogressionofmyopiawassignificantlydifferent:0.48Dperyearforrigid
contactlenswearerscomparedwith1.53Dperyearforspectaclewearers.50However,theallocation
oftreatmentwasnotrandomised.Itwasalsoobservedthatapproximatelyhalfoftheeffectofrigidgas
permeablecontactlenseswasduetotransientcornealflattening.Inanonrandomisedstudyof45rigid
contactlenswearersand45spectaclewearersinSingapore10yearoldchildren,themeanincreasein
myopiaovera3yearperiodof
polymethylmethacrylate(PMMA)hardcontactlenses,thusalteringtheshapeofthecornea. 49
However,therewerehypoxiarelatedcornealchanges.Newrigidgaspermeablelenseswithhigh
oxygenpermeabilityareasuitableandsaferalternative.45Thepotentialmechanismsofactionofrigid
contactlensesincludetransientflatteningofthecornea,andimprovedqualityoftheretinalimagewith
reducedperipheralimageblur.Perhapsrigidcontactlensesmayevenretardaxialelongation.
However,thepermanenceofthesemechanismsofactionisstillunknown.
Ininfantprimateswearingminuscontactlenses,compensatoryoculargrowthmayleadtofunctional
myopia.38,39Alargenumberofreportsontheefficacyofvarioustypesofcontactlenses(silicone
acrylatecontactlenses,hydrophiliccontactlenses,hydrogellenses)werenotrandomised,hadsmall
samplesizes,andhighdropoutrates.4047Inarandomisedclinicaltrialoftheefficacyofsoftcontact
lensesin175childrenbyHornerandassociatesintheUnitedStates,therewasnosignificantdifference
intherateofprogressionofmyopiabetweenthecontactlens(0.36Dperyear)andcontrolgroup
(0.30Dperyear).48
Morrisonin1956fitted1021myopicchildren(79years)flatterthantheflattestcurvaturewith
reductionoftheprogressionofmyopia(meanmyopiaprogression1.19Dperyearinmultifocalgroup
versus1.40Dperyearinsinglevisiongroup)in227myopicchildrenaged612yearsafter1
years.34TheCorrectionofMyopiaEvaluationTrial(COMET)isalargeongoing3yearmulticentre
randomised,doublemaskedtrialevaluatingtheeffectofprogressiveadditionlensesversussingle
visionlensesin469myopicchildren(sphericalequivalentbetween1.25and4.50D)aged611
yearsintheUnitedStates.35,36Theresultsfromthistrialmayprovidenewevidencefortheefficacyof
multifocallenses.
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CONTACT LENSES
ContactlenseshavealonghistoryofuseasopticalcorrectionsincetheirintroductionbyEugenFickin
1888.37Contactlensesmayincreaseperipheralvision,providecosmeticbenefits,andpromotemore
outdooractivity.However,potentialcomplicationsofcontactlensuseincludeallergicconjunctivitis,
cornealinfiltrates,andinfectivekeratitis,andcontactlenshygienecompliancemaybeaproblemin
lessresponsiblechildren.
theprogressiveadditionlensmustbefittedveryhightofacilitatetheuseofthesegmentforreading.In
aclinicaltrialconductedbyLeungandBrowninHongKong,22childrenwereassignedtowear
progressivelenseswith+1.50Daddition,14tolenseswith+2.00Daddition,and32tosinglevision
lenses.Themeanprogressionrateofmyopiawas3.73Dforthechildrenassignedto+1.50D
additions,3.67Dforchildrenwearing+2.00Dadditions,and3.67Dforchildrenwearingsingle
visionlenses(p<0.001).However,theassignmentwasnotrandom:subjectswithevencaserecord
numberswereplacedintheprogressivelensesgroup,whilesubjectswithoddcaserecordnumbers
wereplacedinthesinglevisionlensesgroup.19ATaiwaneserandomisedclinicaltrialbyShihand
colleaguesshowedanonsignificantreductionoftheprogressionofmyopia(meanmyopiaprogression
1.19Dperyearinmultifocalgroup
Whenmyopiaisnotcorrected,lackofaclearvisualimagemayleadtoformdeprivationmyopia.11
Conversely,correctingachildsmyopiawithnegativelensesmayresultincompensatoryaberranteye
growthandthedevelopmentofmyopia.10Animalexperimentshaveshownthatcompensatorychanges
intheaxiallengthofaneyemayoccurinresponsetoerrorsignalsfromlensinduceddefocus.10,12Ina
nonrandomisedclinicaltrialevaluatingparttimedistancespectaclewearintheUnitedStates,43
myopeswerecategorisedintofourtreatmentgroups:(a)fulltimespectaclewear,(b)wearfordistance
viewingandthenaswitchtofulltimewear,(c)wearfordistanceviewingonly,and(d)nonwear.Over
aperiodof3years,therewerenosignificantdifferencesinrefractiveshiftsasmeasuredbynon
cycloplegicdistance
Whenmyopiaisnotcorrected,lackofaclearvisualimagemayleadtoformdeprivationmyopia.11
Conversely,correctingachildsmyopiawithnegativelensesmayresultincompensatoryaberranteye
growthandthedevelopmentofmyopia.10Animalexperimentshaveshownthatcompensatorychanges
intheaxiallengthofaneyemayoccurinresponsetoerrorsignalsfromlensinduceddefocus.10,12Ina
nonrandomisedclinicaltrialevaluatingparttimedistancespectaclewearintheUnitedStates,43
myopeswerecategorisedintofourtreatmentgroups:(a)fulltimespectaclewear,(b)wearfordistance
viewingandthenaswitchtofulltimewear,(c)wearfordistanceviewingonly,and(d)nonwear.Over
aperiodof3years,therewerenosignificantdifferencesinrefractiveshiftsasmeasuredbynon
cycloplegicdistance
Myopiaisclassifiedinasimplemanneras
i)simple
ii)pathological
SimpleMyopiaisnotprogresivebeyondtheamountincludedwithinnormaldevelopment;isassociated
withgoodvisionandrequiresnotreatmentexceptopticalcorrection.
PathologicalMyopiaontheotherhandisadegenerativemyopiaaccompaniedbychangesinthe
posteriorsegmentoftheeyeballwithlengtheningofAPaxisoftheglobe.Besides,theaxial
pathologicalmyopia,thereareothertypesofmyopiaduetodefectsinthecurvatureofcorneaandlens
andduetodrauma.Today,IwillconfinemyremarksonlytopathologicalaxialMyopia.
Thepathologicalmyopiashowsdegenerativechangesintheposteriorpole.Thusitcanbenamedas
degenerativemyopia(DukeElder).Itmayoccurasanindependentdevelopmental(congenital)
conditionorinassociationwithotherocculardiseasesorgeneraldisease.
VonJeagerfirstdescribedcongenitalmyopiain1855.Sincethenanumberofcaseshavebeen
reported.Majorityofcongenitalmyuopiasremainstationary.Someprogressfurtherleadingto
detachmentoftheretina.Visionisgoodinsomecases,whileinothersitissubnormal.
beinducedareformdeprivationandopticaldefocus.Formdeprivationmyopiacanbeinducedbythe
applicationoftranslucentoccludersovertheanimalseyes.Localretinaleffectsmayoccurandthe
resultantscleralgrowthmodulatedbychemicalssuchasdopamine,growthfactors,andmuscarinic
antagonists.79Negativespectaclelensesinchicksinducecompensatoryaxialelongationandmyopia.10
Suitabletherapeuticmodalitiessuchaspharmacologicalinterventionsandopticalcorrectivedevices
thatmayretardtheprogressionofmyopiainmyopicindividualshavebeenreported.The
overwhelmingmajorityofthesereportshavebeencitedinoptometryandnotophthalmologyjournals.
Theopticalcorrectionofmyopiaandoptimalstrategiestopreventtheprogressionofmyopiahavebeen
developedandprescribedlargelybyoptometrists.Ontheotherhand,issuesregardingthecausesand
preventionofmyopiahaveonlygainedinterestamongophthalmologistsintherecentdecade.The
objectiveofthis
Myopiahasbeenknownformorethan2000yearsandwasfirstdescribedbytheancientGreeks.1,2
However,despitetherecordeduseofconvexlensesforpresbyopiainthelate13thcenturyinFlorence,
Italy,thecorrectionofmyopicrefractiveerrorhadtoawaitthedevelopmentofconcavelensesinthe
mid16thcentury.
Myopiamaybeclassifiedasschoolmyopiaoradultonsetmyopia.3Schoolmyopiadevelops
duringtheschoolageandstabilisesaround1517yearsofage,whileadultonsetmyopiadevelopsin
youngadults.Theaetiology,pathogenesis,andtreatmentofmyopiahavebeenhotlydebatedinthe
ophthalmiccommunityfordecades.4Thereareseveraltheoriesonthemechanismofdevelopmentof
myopiaarisingfromdisruptionoftheemmetropisationprocess.Emmetropisationisachievedwhenthe
opticalpoweroftheeyematchestheaxiallength,resultinginafocusedimageofadistantobjectonthe
retinawithoutaccommodativeeffort.5Ithasbeenproposedthatoveractingintraocularmusclesmay
resultinexcessiveaccommodationandinfluenceemmetropisation.6Thetwobasicmechanismsby
whichanimalmyopiamay
INTRODUCTION
Optometrists, through their clinical education, training, experience,
and broad geographic distribution, have the means to provide
effective primary eye and visison care for a significant portion of the
American public and are often the first health care practitioners to
diagnose patients with myopia.
2.
3.
Tellyourdoctorrightawayifanyoftheseunlikelybutserioussideeffectsoccur:signsofinfection
(e.g.,fever,persistentsorethroat),troublebreathing,unusualtiredness,swellingankles/feet,
burning/painful/frequenturination,decreasedsexualinterest/ability,hairloss,musclecramps/pain,See
alsoWarningsection.
Beforetakingitraconazole,tellyourdoctororpharmacistifyouareallergictoit;ortootherazole
antifungals(e.g.,ketoconazole);orifyouhaveanyotherallergies.Thisproductmaycontaininactive
ingredients,whichcancauseallergicreactionsorotherproblems.Talktoyourpharmacistformore
details.
Beforeusingthismedication,tellyourdoctororpharmacistyourmedicalhistory,especiallyof:liver
disease(orhistoryofliverdiseasewithotherdrugs),kidneydisease,heartdisease(e.g.,coronaryartery
disease,heartvalvedisease,congestiveheartfailure),severelungdisease(e.g.,chronicobstructive
pulmonarydisease
s
Tunikavaskularis(lapisuvea)merupakanlapisantengahbolamataterdiri
ataskhoroid,badansiliarisdaniris.
Tunikaneuralis(lapisretina)merupakanlapisandalambolamataterdiriatasretina.
Howtouseitraconazole
ReadthePatientInformationLeafletprovidedbyyourpharmacistbeforeyoustart
takingitraconazoleandeachtimeyougetarefill.Ifyouhaveanyquestions,consult
yourdoctororpharmacist.
Takethismedicationbymouthwithafullmeal,usuallyonceortwicedailyoras
directedbyyourdoctor.Thecapsulesmustbeswallowedwhole.
Thedosageisbasedonyourmedicalcondition,responsetotreatment,andother
medicationsyoumaybetaking.Besuretotellyourdoctorandpharmacistaboutall