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Veins

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 Venous circulation (1)

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 Venous circulation (2)

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 Deep venous system

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 Superficial venous system

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 Head and neck veins

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 Veins (1)

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 Veins (2)

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 Veins (3)

Tunica media

Intima

Adventitia
Internal
elastic membrane
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 Vascular tunics

Valve
Tunica intima
(endothelium)

Elastic membrane

Tunica media
External
elastic
lamina
Tunica externa
(adventitia)

Artery Vein
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 Capillaries (1)

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 Capillaries (2)

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 Capillary (3)

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 Capillary compartment

Preferential canal

Arteriola

Venule
Sphincters

Capillary

Lymphatic canaliculus
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 Venous system

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 Blood flow (1)

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 Blood flow (2)

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 Venous return

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 Foot pump

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 Venous disease

Telangiectasis Varicose veins Oedema Lipodermatosclerosis Venous leg ulcer

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 Varicose vein

Membrane adhesion -
Molecule expression
(ICAM-1, E-selectin,…)

Venous valve

Venous wall
remodeling

Pressure and shear stress

induced gene expression
(TNF, IL-1, …)

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 Venous valves (1)

Competent valve: closed Competent valve: open Passage of micronized Daflon

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500 mg through open valve
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 Venous valves (2)

Valve at early stage Inflamed valve: closed Inflamed valve: open

of inflammation Non Commercial Use Only
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 Venous valves (3)

Inflamed incompetent valve Varicose vein + inflamed Varicose vein + inflamed

incompetent valve incompetent valve + reflux
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 Oedema (1)

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 Oedema (2)

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 Oedema (3)

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 Edema formation

Normal capillaries Edema formation

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 Phlebitis

Inflammation
of the inner
layer

Healthy vein Vein with phlebitis

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 Venous thrombosis (1)

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 Venous thrombosis (2)

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