t (horas)

Conc Plas (mcg/ml) (mg/L)

0.25
8.21 C0=
0.25
7.87 VD=
1
7.23 Kd=
3
5.15
6
3.09
12
1.11
18
0.4
0.25
0.5
1
3
6
12
18

8.56770584
35.0152078
0.17

La actividad del farmaco es d

Para que se elimine el 99.9%
NO

2.1053529235
2.0630580624
1.9782390362
1.6389967147
1.1281710909
0.1043600153
-0.9162907319

9
8
7
6
5
4
3
2
1
0
0

10

12

14

16

18

20

mg/L
L
/h

2.5
2

f(x) = - 0.170282106x + 2.1486975613

R = 0.9999994442

actividad del farmaco es de 8.55 horas

1.5
a que se elimine el 99.9% del farmaco se necesitan 32.6 horas
1
0.5
0
-0.5
-1
-1.5

18

20

10

12

+ 2.1486975613

10

12

14

16

18

20

t (horas)

Conc (mg/L) t (horas)

Ln C (terminal) Ln Cex
3
2.521
3.2
2.493
3.5
2.437
3.2
2.381
3.6
2.325
3.8
2.213
4.1
1.877
48
3.2
48 1.1631508098
72
1.6
72 0.4700036292
96
0.8
96 -0.2231435513
120
0.4
120 -0.9162907319

1.5
f(x) = - 0.0288811325x + 2.5494451709
R = 1
1

0.5

0
40
-0.5

-1

-1.5

50

60

70

80

90

100

110

120

Cex
CR
12.4410315 9.44103148
12.0975143 8.89751428
11.4386732 7.9386732
10.8157132 7.61571317
10.2266801 6.62668009
9.1431046 5.3431046
6.53387381 2.43387381

LnCR
1 2.24506524
2 2.18577194
4 2.07174616
6 2.03021364
8 1.89110394
12 1.67580687
24 0.88948415

1
2
4
6
8
12
24
48
72
96
120

2.5
f(x) = - 0.0586379366x + 2.3330791883
R = 0.9930389779

2
1.5
1

100

110

120

130

0.5
0
0

10

15

20

25

3
3.2
3.5
3.2
3.6
3.8
4.1
3.2
1.6
0.8
0.4

330791883

15

20

25

30

1
2
4
6
12
24
48
72
96

5.6
5.4
5.2
4.9
3.9
3.2
2.2
0.88
0.42

1
2
4
6
12
24
48
72
96

1.7227666
1.68639895
1.64865863
1.58923521
1.36097655
1.16315081
0.78845736
-0.12783337
-0.86750057

2
f(x) = - 0.0261523007x + 1.7644844094
R = 0.9844039198

1.5
1
0.5
0
0
-0.5
-1

20

40

60

80

100

1
2
4
6
12
24
48
72
96

1.72
6
1.68
1.65
1.59
1.36
5
1.16
0.79
-0.13
4
-0.87

4094

60

80

100

1.5

f(x) = - 0.026152
R = 0.984693772

120

20

40

60
0.5

0
0
-0.5

-1

20

2
f(x) = - 0.0261529734x + 1.7660942351
R = 0.9846937727

1.5

1
40

60

80

100

120

0.5

0
0
-0.5

-1

20

40

60

80

100

120

100

120

120
130
140
150
165

0.92
9
13.2
15.8
17.6

120
130
140
150
165

0.26
6.6
10.2
13.6
15.8

120
130
140
150
165

0
10
20
30
45

0.92
9
13.2
15.8
17.6

0
10
20
30
45

0.26
6.6
10.2
13.6
15.8

0
10
20
30
45

0
10
20
30
45

0.92
9
13.2
15.8
17.6

0
10
20
30
45

19.08
11
6.8
4.2
2.4

0.954
0.55
0.34
0.21
0.12

0
10
20
30
45

19.08
11
6.8
4.2
2.4

0
10
20
30
45

19.08
11
6.8
4.2
2.4

0
10
20
30
45

2.71441762
0
10
20
30
45

0
3.16227766
4.47213595
5.47722558
6.70820393

0.92
9
13.2
15.8
17.6

0.5
11
14.4
16.2
18.6

120
130
140
150
165

0.08
0.6
13.6
15.4
18

0.5
11
14.4
16.2
18.6

0
10
20
35

0.6
13.6
15.4
18

0
10
20
30
45

95%
55% Kd
34% r2
21%
12%

0
10
20
30
45

1.28057837
1.04139269 kd
0.83250891 r2
0.62324929
0.38021124

2.67214153
2.22398009
1.89453647
1.61342865
1.3388659

0
10
20
30
45

0.017
0.87

0.02
0.994

0.04227609
0.49043753 kd
0.81988114 r2
1.10098897
1.37555172

0.029
0.968

20
18

f(x) = 2.5744031954x + 1.0991465064

R = 0.9921479223

16
14
12
10
8
6
4
2
0
0

5064

0.5
1
2
3
4
8
12
16
24

2.8
2.24
1.51
1.11
0.88
0.53
0.4
0.31
0.19

2.5

1.5

0.5

0
0

2.5

1.5

0.5

0
0

10

15

20

25

30

25

30