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Sublingual Buprenorphine For Acute Renal Colic Pain Management: A Double-Blind, Randomized Controlled Trial
Sublingual Buprenorphine For Acute Renal Colic Pain Management: A Double-Blind, Randomized Controlled Trial
Sublingual Buprenorphine For Acute Renal Colic Pain Management: A Double-Blind, Randomized Controlled Trial
ORIGINAL RESEARCH
Open Access
Background
Renal colic is a severely painful condition frequently
encountered in emergency departments (EDs) [1]. As
relieving the patients pain and suffering is one of the first
responsibilities of emergency physicians, finding safe and
effective methods to accomplish this task is of paramount
importance [2]. The routine practice for pain reduction in
renal colic is intravenous (IV) administration of analgesics,
either non-steroidal anti-inflammatory drugs or opioids
[3]. IV administration of these drugs, although effective,
takes a lot of staff time, which is not ideal in constantly
overcrowded EDs. On the other hand, time to analgesia is
an indicator of ED service quality, which will be much
longer when using a parenteral route for analgesia [4]. The
ideal analgesic drug is one with enough efficacy and the
fewest side effects as well as easy route of administration.
* Correspondence: mjalili@tums.ac.ir
1
Emergency Medicine Department, Imam Hospital, Tehran University of
Medical Sciences, Keshavarz Blvd, Tehran, Iran
Full list of author information is available at the end of the article
Buprenorphine is an analgesic with mixed agonistantagonist properties which has been shown to have a
role in acute pain management in postoperative pain
and orthopedic injuries [5,6]. However, there is only one
study evaluating its effectiveness in renal colic [7] and,
to the best of our knowledge, there is no study using the
sublingual form of buprenorphine as an analgesic in
renal colic. Its sublingual form can be administered
rapidly and with no need for IV lines, and hence may be
an ideal drug for acute pain management in renal colic.
We compared the effectiveness of sublingual buprenorphine with that of IV morphine sulfate for pain
management in ED patients with renal colic.
Methods
Study design
2014 Payandemehr et al.; licensee Springer. This is an open access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly cited.
Page 2 of 5
Baseline demographic and clinical variables were compared using independent Students t-tests or exact tests.
Repeated measure ANOVA was used to assess the effect
of intervention on pain scores across time and between
the study groups at each time point. Side effects were
compared using 2 tests and P <0.05 was considered
statistically significant. The sample size was calculated as
25 for each group according to the study conducted by
Finlay et al. [7] with and error being 0.05 and 0.20,
respectively. We enrolled 80 patients to cover possible
withdrawals from the study. All analyses were performed
using the Statistical Package for Social Science version
15 (SPSS Inc., Chicago, IL, USA).
Results
Patient characteristics
Measurements
Page 3 of 5
Buprenorphine n = 37
Morphine n = 32
9.84 (0.50)
9.78 (0.55)
35 (10)
31 (10)
13.38 (1.55)
13.13 (1.28)
90.95 (9.40)
94.63 (11.48)
Female (%)
Mean age (year)*
Discussion
The results of this study demonstrated that administration of 2 mg sublingual buprenorphine effectively
reduced pain in patients with acute renal colic. Although
the number of patients was not enough to perform
equivalency tests, the results showed that the analgesic
effect of buprenorphine was comparable to 0.1 mg/kg IV
morphine.
Table 2 Pain scores in study groups
Group
NRS0*
NRS20*
NRS40*
Rescue analgesia**
Buprenorphine
9.84 (0.50)
5.22 (2.66)
2.30 (2.09)
5 (13.5%)
Morphine
9.78 (0.55)
4.25 (2.51)
1.78 (2.45)
2 (6.25%)
*Mean numerical rating score (SD) at baseline and after 20 and 40 minutes.
**Number of patients who needed rescue analgesia after 40 minutes.
Page 4 of 5
Nausea
Vomiting
Drowsiness
Pruritus
Dizziness
Respiratory depression
Hypotension
Buprenorphine
20 (54%)
4 (10.8%)
6 (16.2%)
0 (0%)
23 (62.1%)*
10 (27%)
17 (45.9%)
20 (62.5%)
3 (9.3%)
6 (18.7%)
1 (3.1%)
12 (37.5%)
11 (34.3%)
15 (46.8%)
0.47
1.000
0.782
0.464
0.041
0.508
0.938
Morphine
P value
whose NRS was 10 at the beginning; however, this situation is expected to be similar in both groups and does
not seem to influence the change in NRS during the
observation time. Another limitation of our study was
the use of 2 mg buprenorphine tablets which may be the
cause of slightly higher rate of side effects in this group;
using smaller doses and then titrating it to effect may
reduce the occurrence of side effects. Finally, this study
did not find a significant difference between the two
groups probably because of the small sample size.
Page 5 of 5
Conclusions
In conclusion, sublingual buprenorphine can be used as
an effective analgesic with minor side effects for acute
pain relief in patients with renal colic, and its effectiveness is comparable to that of IV morphine.
Abbreviations
ED: Emergency department; IV: Intravenous; NRS: Numeric rating scale.
Competing interests
All authors declare that they have no competing interests.
Authors contributions
PP and MJ developed the study questions, designed the methods for data
acquisition, and supervised the collection of data. BMD performed statistical
analysis. PP, MJ, and BMD jointly participated in drafting the manuscript. AD
helped in the interpretation of data and also revised the manuscript critically.
All authors read and approved the final version of the manuscript.
Author details
1
Emergency Medicine Department, Imam Hospital, Tehran University of
Medical Sciences, Keshavarz Blvd, Tehran, Iran. 2Tehran University of Medical
Sciences, Keshavarz Blvd, Tehran, Iran. 3Department of Pharmacology, School
of Medicine, Tehran University of Medical Sciences, Poursina St, Keshavarz
Blvd, Tehran, Iran.
Received: 26 July 2013 Accepted: 16 December 2013
Published: 3 January 2014
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