PATHOPHYSIOLOGY

NON-MODIFIABLE

MODIFIABLE

Heredofamilial Hx of Glaucoma (Maternal)

Past History

Increasing age (45-65 yrs.old)

HPN

OBSTRUCTION OCCURS AT THE

TRABECULAR MESHWORK AND THE CANAL
OF SCHLEMM
BLOCKAGE OF ANTERIOR CHAMBER ANGLES

HYPERPRODUCTION OF AQUEOUS HUMOUR

INTRAOCULAR PRESSURE

PUPILLARY DILATION/ IRIS DISPLACE

FORWARD
ANGLE
CLOSURE

INHIBITION OF BLOOD SUPPLY TO THE OPTIC

NERVE & RETINA

OPTIC NERVE DAMAGE AND ISCHEMIA OF

DELICATE TISSUES (IRIS & CILIARY BODY)

OPTIC NERVE CUPPING &

PALLOR (BASED ON
OPTHTHALMOSCOPIC
EXAMINATION)
The axons of the optic nerve
leave the eye by passing
through a structure called
the lamina cribrosa, which
is a mesh-like structure
composed of pores or holes
through which the axon
bundles must cross. It is
thought that the site of initial
damage may be to the axons
as they pass through the
lamina cribrosa. Mechanical
compression and/or
decreased blood flow of the

PAIN
AROUND
EYES
Due to
pressure

CLOUDY
VISION
Due to
corneal
edema

HAZY
APPEARING
CORNEA
Due to
corneal
edema

NAUSEA

Result from the

activation of
protective
physiological
mechanisms that
exist in order to
eliminate toxins
from the body.
Increasing IOP
stimulate pain
and causes
nausea.

RAINBOW OF
COLOR
AROUND
LIGHTS
Due to optic
nerve
damage

PERIPHERAL
VISION
A significant
number of nerve
fibers are
damaged; blind
spots develop in
the field of vision