Ebola Haemorhagic fever:

Haemorrhage

Multi-organ failure + shock

Differentials: Complicated malaria, typhoid, bacterial gastroenteritis,

leptospirosis

Aetiology: Spread through blood and bodily fluid transmission. Use of

personal protecticve equipment reduceds ths risk.
Microvascular instability causing capillary leaks and impaired haemostasis
along with DIC are pathognomic?
Non-specific presentations of : fever, headache, asthenia, myalgias,
abdominal pain ( esp over liver), nausea and vomiting and diarrhoea. Fleeting
maculopapular rash maybe seen.
Lab findings: mild lymphopenia, thrombocytopenia, elevated liver
transaminases, AST>> ALT. Leucocytosis in late stage.

Diagnosis: Lab- Positive ELISA antigen and PCR testing for Ebola along with
negative ELISA IgG?

Treatment : Conservative as for septive shock. Antimalarials and broad spec

antibioitics should be administered until diagnosis of viral HF is confirmed. No
approved vaccines presently. COntact tracing important/