Professional Documents
Culture Documents
4-3 - Batch Organic Chemical Synthesis
4-3 - Batch Organic Chemical Synthesis
Page 1 of 16
Module-1
Table of Contents
1
1.2
1.3
1.4
1.5
1.6
1.7
P&IDs .............................................................................................. 10
1.8
References ............................................................................................. 16
Page 2 of 16
Module-1
Page 3 of 16
Module-1
Page 4 of 16
Module-1
Glassed steel
Stainless steel
Separation devices are usually pressure filter or centrifuge. The dryer is either
a standalone device or a combined pressure filter or centrifuge.
Page 5 of 16
Module-1
Reactor vessel
In a continuous-stirred-tank-reactor
(CSTR), one or more fluid reagents
are introduced into a tank reactor
equipped with an impeller. The
impeller stirs the reagents to ensure
proper mixing.
Impeller (agitator) in a CSTR
Page 6 of 16
Module-1
Filter plate/sieve/screen
Discharge Port
Page 7 of 16
Module-1
Inverting-filter centrifuge
Centrifuge basket
Page 8 of 16
Module-1
Tray Dryer
Tray Dryer
Drum dryer
Drum dryer
Page 9 of 16
Module-1
1.7 P&IDs
P&ID is an acronym that means Piping and Instrumentation Diagram - a
diagram showing piping and instrumentation connections between process
units in chemical plants, power plants, water treatment and similar plants. API
facilities almost universally include process trains comprising reactor,
crystallizer, separation device, and dryer to produce bulk quantities of powder.
Page 10 of 16
Module-1
Page 11 of 16
Module-1
Page 12 of 16
Module-1
Page 13 of 16
Module-1
Combination (mixing)
Separation (distillation)
Page 14 of 16
Module-1
Typical vertical processing facility designed for batch production with barrier separation between processing steps
Process
Technical
Services
Process
Technical
Services
Solids
Charging
1
Solids
Charging
2
Liquid
Charging
Solids
Charging
3
Filter
Dryer
Reactor
1
Reactor
2
Reactor
3
Elevator
Process
Technical
Services
Solution
Mother
Liquor
Distillate
Page 15 of 16
Tray
Dryer
Module-1
2 References
ISPE Baseline Guide-1
(second edition)
Active Pharmaceutical Ingredients
International Society for
Pharmaceutical Engineering, Tampa,
FL 33607, USA
(2007)
Page 16 of 16