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Learning Zone: An Overview of Cardiovascular Disease Risk Assessment
Learning Zone: An Overview of Cardiovascular Disease Risk Assessment
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An overview of cardiovascular
disease risk assessment
NS621 Westerby R (2011) An overview of cardiovascular disease risk assessment.
Nursing Standard. 26, 13, 48-55. Date of acceptance: July 18 2011.
Abstract
Cardiovascular disease (CVD) risk assessment is being undertaken in
the UK as a result of a national drive to reduce premature mortality and
the economic burden of vascular disease. This article focuses on ways
in which primary care teams can implement a systematic approach to
CVD risk assessment. A systematic approach to CVD risk assessment
includes identification of the target population, the collection of
information and data to calculate a CVD risk score, and management
of the results. Primary care teams can work successfully with lifestyle
teams and public health to provide a comprehensive service.
Author
Ruth Westerby
Clinical lead for cardiovascular disease prevention, stroke and
evidence-based health care, Education for Health, Warwick, and senior
lecturer in health and social care, University of Wolverhampton.
Correspondence to: r.westerby@wlv.ac.uk
Keywords
Cardiovascular disease, coronary heart disease, stroke
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Introduction
CVD risk assessment is not solely about
preventing heart attacks. The national
initiative to identify and prevent vascular
diseases (known in England as the Health
Check process) includes heart attack, stroke,
chronic kidney disease and diabetes
(Department of Health (DH) 2009).
Collectively, CVD accounts for 170,000 deaths
each year in England and four million people
living with long-term illness and disability
(DH 2007). The national service frameworks
for chronic heart disease (DH 2000), diabetes
(DH 2001) and renal disease (DH 2005), and
the National Stroke Strategy (DH 2007)
highlight the need for prevention of CVD. The
document Putting Prevention First: Vascular
Checks (DH 2008a) combined the assessment
NURSINGSTANDARD / RCNPUBLISHING
TABLE 1
Approaches to cardiovascular disease prevention
High-risk approach
Population approach
(Bovet 2009)
NURSINGSTANDARD / RCNPUBLISHING
1 Consider the
reasons why the burden
of CVD is anticipated to
increase. Make a list of
the factors that might
contribute to this and
outline how these could
be addressed.
Identification
Deaths from CVD, particularly premature
deaths, are not evenly distributed in the UK
and it is therefore logical to establish who
and where those most at risk are, and to
start the process in a targeted fashion, within
the context of assessing all people aged
40 to 74. For example, unskilled men
experience three times more deaths from
coronary heart disease than the professional
occupation groups. This is attributed to the
ways in which socioeconomic status affects
lifestyle and behaviour patterns, ease of
access to health care and chronic stress
(WHO 2009).
Deaths are 50% higher in the south Asian
community than in the general population
(Care Quality Commission 2009). People
from India are at less risk than Bangladeshi
and Pakistani communities (Bhopal 2000),
but overall the south Asian population is at
increased risk.
NURSINGSTANDARD / RCNPUBLISHING
3 Visit the
QRisk2 website at
http://qintervention.org
and input an example of
patient data. Change the
parameters and observe
the effects on overall
risk score.
FIGURE 1
Identification of people at high risk of diabetes
Key
BMI = body mass index
BP = blood pressure
FPG = fasting plasma glucose
HbA1c = glycated haemoglobin
OGTT = oral glucose tolerance test
6.5%/48mmol/mol (symptoms)
6.5%/48mmol/mol
6.5%/48mmol/mol
(no symptoms)
Either
HbA1c
6%/42mmol/mol to
<6.5%/48mmol/mol
Repeat
HbA1c
OGTT
6.5%/
48mmol/
mol
Non-diabetic
hyperglycaemia:
intensive lifestyle
advice
2hr glucose
7.8-11.0mmol/L
2hr glucose
11.1mmol/L
Either
<6%/42mmol/mol
Healthy lifestyle
advice
Diabetes
diagnosis
Yes
7mmol/L (symptoms)
BMI 30 (or 27.5
if Indian, Pakistani,
Bangladeshi, other
Asian or Chinese or
BP 140/90mmHg
11.1mmol/L
FPG*
6-7mmol/L
2hr glucose
7.8-11.0mmol/L
No
No further
testing
2hr glucose
OGTT
<6mmol/L
Non-diabetic
hyperglycaemia:
intensive lifestyle
advice
Healthy lifestyle
advice
* The values in the diagram are for laboratory tests. For FPG POCT, use a value of less than 5.5mmol/L
to proceed to healthy lifestyle advice. If the FPG POCT value is 5.5mmol/L or above, repeat using a
venous blood sample for laboratory testing and follow the diagram according to results.
NURSINGSTANDARD / RCNPUBLISHING
If at risk
Diabetes filter
BP measurement
Cholesterol test
Ethnicity
Family history
Physical activity
Smoking status
Gender
Age
Initially,
primary care
trusts decide
which people
to call first
and where
the checks
can be
accessed
(for example
general
practice and
pharmacy)
bearing in
mind the
need to
tackle health
inequalities
Risk assessment
FIGURE 2
If blood
sugar high
Raised BP
DM
IFG/IGT
Signpost
or refer to
lifestyle
interventions
Serum creatinine
Assessment for
hypertension
CKD assessment
Anti-hypertensives
prescription*
Statins prescription
offered*
IFG/IGT lifestyle
management advice
Weight management
on referral
Exercise on prescription
or other physical
activity intervention
Behaviour change,
for example Mid-life
LifeCheck
Risk management
eGFR low
High
Oral glucose
tolerance test
Risk
assessment
Communication of risk
Recall
Key
BP: blood pressure
CKD: chronic kidney disease
DM: diabetes mellitus
eGFR: estimated glomerular filtration rate
IFG: impaired fasting glucose
IGT: impaired glucose tolerance
Exit
Exit
Exit
Exit
Diabetes High risk Hypertension CKD
register annual
register
register
reviews
(Adapted from Department of Health 2008a)
NURSINGSTANDARD / RCNPUBLISHING
4 Using the
information in Table 2,
what BMI would be
classed as obese for a
person of south Asian
ethnic origin? Now list
the factors that might
contribute to obesity
and suggest strategies
or lifestyle modifications
to lower obesity in this
population.
TABLE 2
Factors to consider during cardiovascular disease risk assessment
Data required
Age
40-74 inclusive.
Gender
Male or female.
Smoking status
Framingham equation (DAgostino et al 2008) smoking or quit within the past year.
QRisk2 smoking or non-smoking (including previous smoker) (Hippisley-Cox et al 2007).
Family history
History of heart attack or stroke in first-degree relative under 60 (included in the QRisk2 not in the
Framingham equation). Joint British Societies (JBS) (2005) guidelines provide an additional calculation
to obtain a score if using the Framingham equation, which is to multiply the score obtained by 1.3.
Ethnicity
QRisk2 incorporates self-assigned ethnicity. The Framingham equation does not include a measure of
ethnicity. The additional calculation suggested by JBS (2005) is to multiply the score obtained by 1.4
if ethnic origin was Indian sub-continent. In the Health Check process, ethnicity such as south Asian
and black minority ethnic groups automatically suggests further testing for the presence of diabetes
since it highly prevalent in those ethnic groups.
Cholesterol test
The Framingham equation requires measurement of total serum cholesterol and high density
lipoproteins (HDL). QRisk2 requires the measurement of the total serum cholesterol to HDL ratio.
There are no specific thresholds for total cholesterol for primary prevention, but the National Institute
for Health and Clinical Excellence (NICE) (2008c) and JBS (2005) guidance suggest that a total
cholesterol of >7.0mmols/L or a total cholesterol to HDL ratio of >6 should prompt assessment of
familial hypercholesterolaemia.
Systolic and diastolic BP measurements are required to ascertain the level of risk from diabetes,
chronic kidney disease and hypertension. If BP is above the threshold (140/90mmHg) then it must
be measured again on two separate occasions by the GP practice team. If BP remains above the
threshold, then the patient will require screening for diabetes and chronic kidney disease. Local
guidelines usually also have an upper safe limit for BP (usually around 180/110mmHg) above which
the patient should be reviewed by a GP immediately.
Individuals should aim to engage in 30 minutes of moderate activity, five days a week. NICE (2006
and 2008b) guidance advocates the use of the GP Physical Activity Questionnaire, which measures
levels of physical activity and links this to cardiovascular risk (DH 2006).
NURSINGSTANDARD / RCNPUBLISHING
BOX 1
Methods to help support behaviour change
4Assisting people to plan, create and share specific and relevant goals.
4Helping people to anticipate difficulties and challenges associated with
making changes, and preparing them to cope with these.
(National Institute for Health and Clinical Excellence 2007)
Conclusion
There are several ways in which primary care
can contribute to the CVD risk assessment
process. It is important to be able to identify
people at high risk of developing CVD.
Everyone in the UK is to some degree at risk
of CVD, and a universal information and
support structure should exist for all.
However, some groups and communities
are at higher risk and will require greater
intervention and effort. It is important to
work with providers outside the clinical arena
NURSINGSTANDARD / RCNPUBLISHING
References
Association of Public Health
Observatories (2007) Public Health
Observatories. www.apho.org.uk
(Last accessed: November 11 2011.)
Bhopal R (2000) What is the risk
of coronary heart disease in South
Asians? A review of UK research.
Journal of Public Health. 22, 3,
375-385.
Bovet P (2009) Primary Prevention
of CVD. Ministry of Health,
Seychelles and University of
Lausanne, Switzerland.
Capewell S (2008) Will screening
individuals at high risk of
cardiovascular events deliver large
benefits? No! British Medical
Journal. 337, a1395.
Care Quality Commission (2009)
Closing the Gap: Tackling
Cardiovascular Disease and Health
Inequalities by Prescribing Statins
and Stop Smoking Services. Care
Quality Commission, London.
DAgostino RB, Vasan RS, Pencina MJ
et al (2008) General cardiovascular
risk profile for use in primary care:
the Framingham heart study.
Circulation. 117: 743-753.
Department of Health (2000)
National Service Framework for
Coronary Heart Disease. The
Stationery Office, London.
Department of Health (2001)
National Service Framework
for Diabetes. The Stationery
Office, London.
Department of Health (2005)
National Service Framework for
Renal Services Part Two: Chronic
Kidney Disease, Acute Renal Failure
and End of Life Care. The Stationery
Office, London.
Department of Health (2006) The
General Practice Physical Activity
Questionnaire (GPPAQ). The
Stationery Office, London.
Department of Health (2007)
National Stroke Strategy. The
Stationery Office, London.
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In practice
After reading a learning zone
article on wound care, Amajit,
a senior staff nurse on a surgical ward,
approached the nurse manager with
concerns about wound infections.
Following an audit, which Amajit
undertook, a protocol for dressing
wounds was established that led to a
reduction in infections on the ward
and across the directorate. Amajit
used this experience for her practice
profile and is now taking part in
a regional research project.
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