The Cell Theory (2.1.1 / 2.1.2) Function of Life (2.1.3)

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Cell Theory (2.

1)
The cell theory (2.1.1 / 2.1.2)

Function of life (2.1.3)

1. The cell is the smallest unit of life

Remember: MRS GREN

2. All living things are made of cells (or cell products)

Movement
Reproduction
Sensitivity (to stimuli)

3. Cells arise from pre-existing cells


Evidence:

Growth
Respiration
Excretion
Nutrition

With the invention of microscopes (Janssen)


scientists could see cells (Hooke, Leeuwenhoek)
Pasteur demonstrated that cells couldnt grow in
sterile conditions (disproved abiogenesis)

Cell size (2.1.4 - 2.1.6)


The rate of metabolism (e.g. cell respiration) is a function of a cells volume
The rate at which material is exchanged (needed for metabolism) is a function of a cells surface area
When a cell grows, volume grows quicker than surface area and the cell must divide or die
Many cells contains structures (e.g. microvilli) to increase their SA:Vol ratio
Calculating cell sizes:
Magnification = Size of image (magnified) Actual size of object
Relative sizes:
Eukaryote (10 - 100m) > Organelle (~10m) > Bacteria (1 - 5m) > virus (100nm) > membrane (7.5nm)

Differential gene expression (2.1.7 / 2.1.8)


Differentiation is the process by which newly-formed cells specialize as they mature
Cells in multi-cellular organisms share identical genomes but differ in gene expression
Chemical signals lead to differential gene expression and thus specialization of cells
The combination of different cell types can give rise to emergent properties

Stem cells (2.1.9 / 2.1.10 / 4.4.12 / 4.4.13)


Stem cells retain the capacity to divide and differentiate along different pathways
Therapeutic cloning can be used to regenerate skin cells in burns victims
somatic cell

nucleus
Reproductive
cloning

fusion
surrogate
stem cells
egg cell

Therapeutic
cloning

enucleated
egg
tissue culture

Arguments For Therapeutic Cloning:


May be used to cure diseases (e.g. diabetes)
Stem cell research may promote future discoveries
Cells cultured when embryos lack nervous system

Arguments Against Therapeutic Cloning:


Involves creation and destruction of embryos
Rapidly dividing cells may become cancerous
At more cost, other technologies fulfill same role

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