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Note 15 PDF
Note 15 PDF
ANTI-MIGRINE DRUGS
Acute Attack
Mild to
Moderate
NSAIDs
Prophylaxis
Moderat to
Sever
Anti- emetics
prokinetic
adrenergic
blockers
Specific drug
Diclofenac
5-HT Agonist
Ca channel
blockers
5-HT2
antagonist
Propranolol
Flunarizine
Pizotifen
Metoprolol
Nicardipine
Cyprohepatadine
5HT2 antagonist
/partial agonist
Methysergide
Other
Amitryptyline
Aspirin
Diphenhydramine
Metocloperamide
Sumatripan
Paracetamol
Promethazine
Domperidone
Almotriptan
Nadolol
Nifedipine
Sertraline
Ibuprofen
Naratriptan
Atenolol
Nimodipine
Fluoxetine
Indomethacin
Pizatriptan
Timolol
Verapamil
Clonidine
Naproxene
Zolmitriptan
Ergotamine
Imipramine
Valporate
Opioids
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USES
SIDE EFFECT
Refractory cases of
acute attack of
migraine(rarly)
Prevent vomiting.
Promethazine
Metocloperamide
Domperidone
Almotriptan
Naratriptan
Pizatriptan
Zolmitriptan
Ergotamine
5-HT Agonist
ACTION
Analgesic.
Diphenhydramine
Diclofenac
Sumatripan
PHARMACOKINETIC
Given orally.
they must be given early to be absorbed before
there is vomiting.
Malaise ,fatigue.
Sedation.
Dizziness, vertigo, nausea & vomiting.
feeling of chest pressure, tightness & pain.
CARDIAC ARRHYTHMIA & myocardial infarction.
due to coronary artery spasm.
+ effects
on CNS
NSAIDs
Anti- emetics
prokinetic
Moderat to Sever
attack
Mild to Moderate
attack
DRUG
t is 2 hrs
DOSE.
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Other
5HT2 antagonist
/partial agonist
5-HT2
Ca channel blockers
antagonist
adrenergic blockers
Propranolol
PHARMACOKINETIC
PROPRANOLOL (effect ,
also prevent migraine ).
Metoprolol
Nadolol
Atenolol
Timolol
Flunarizine
Nicardipine
Nifedipine
Nimodipine
Verapamil
Pizotifen
Cyprohepatadine
Methysergide
Amitryptyline
Imipramine
Sertraline
Fluoxetine
Clonidine
Valporate
ACTION
USES
Fatigue.
Broncho-constriction.
Block Ca channel.
antagonize5-HT2 receptors.
Atropine like action.
Antagonize 5-HT2 R & H 1 R.
Block Ca channels
It is 5HT2 antagonist /partial agonist
SIDE EFFECT
Weight gain.
Anti-cholinergic side effects.
Sedation.
weight gain.
Serious Toxicities like;
o RETROPERITONEAL
obstruction to the Ureters.
o Subendocardial, Pericardial or Pleural fibrosis.
Nausea, vomiting & diarrhoea.
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