Curriculum Vitae 1 Dr. Rosario R.

Trifiletti

Dr. Rosario R. Trifiletti M.D. Ph.D.

Date of Preparation May 1, 2010

Personal Data

Name: Dr. Rosario R. Trifiletti, MD, PhD

Birthdate : 10/16/58 (Age 51)
Birthplace: Flushing, NY
Residence: 25 Smith Hill Road Airmont, NY 10952
Citizenship: U.S.
Married to Mrs. Eileen Trifiletti (neè McNamara) RN, BSN , two children
Current email addresses: rtrif@aol.com; trifmd@gmail.com

Academic Training

College: attended Seton Hall University, South Orange, NJ.

received B.S. (magna cum laude) in Chemistry, 1979.

University: attended Johns Hopkins University School of Medicine, Baltimore, Md.

Fellow in Medical Scientist Training Program
received M.D., 1986.
received Ph.D. in Pharmacology and Experimental Therapeutics, 1986.
Thesis title: " A Biochemical Study of Multiple Drug Recognition Sites on
Central Benzodiazepine Receptors"
Thesis advisor: Dr. Solomon H. Snyder

Traineeship

1986-1988: Resident, Department of Pediatrics

The Babies Hospital, Columbia-Presbyterian Medical Center NYC, NY

1988-1991: Pediatric Neurology Fellow, Department of Neurology

The Neurological Institute of New York, Columbia-Presbyterian Medical Center NYC, NY

Medical Licensure / Board Certification

Medical Licensure in New York State License # 176660 (active)

Medical Licensure in New Jersey License # MA-53137 (active)
Board certified in Pediatrics as of 2/92 (re-certification pending)
Board certified in Neurology (with special competence in Child Neurology) as of 11/92

Military service
None

Membership in Professional Societies:

The American Medical Association

The Society for Neuroscience
The American Academy of Neurology
Curriculum Vitae 2 Dr. Rosario R. Trifiletti

The Child Neurology Society

The American Academy for the Advancement of Science

Academic Appointments

7/1/91-11/1/92 : Assistant Professor of Neurology

Division of Child Neurology
The Neurological Institute of New York, Columbia-Presbyterian Medical Center NYC, NY

11/1/92-3/1/94 Florence and Herbert Irving Assistant Professor of Neurology

Division of Child Neurology
The Neurological Institute of New York, Columbia-Presbyterian Medical Center NYC, NY

Assistant Professor of Pediatrics

Department of Pediatrics
Babies Hospital
Columbia-Presbyterian Medical Center

3/1/94- 7/1/02 Assistant Professor of Neurology, Neuroscience and Pediatrics

The New York Hospital-Cornell Medical Center
New York, NY

7/1/02 – 9/1/03 Associate Professor of Neurology and Pediatrics

The New York Medical College
Valhalla, NY

9/1/03-11/17/06 Associate Professor of Neurology and Pediatirics

UMDNJ/Newark
Newark, NJ

Hospital Appointments

7/1/91-3/1/94 : Assistant Attending

Division of Child Neurology
The Neurological Institute of New York, Columbia-Presbyterian Medical Center NYC, NY

3/1/94 – 7/1/02 Assistant Attending

Department of Pediatrics
Division of Child Neurology
The New York Hospital
New York, NY

3/1/94- 7/1/09 Staff Neurologist and Assistant Pediatrician

Blythedale Children's Hospital
Valhalla, New York

7/1/02- 7/1/03 Attending and Chief, Division of Child Neurology

St. Vincent’s Hospital and Medical Center
153 W. 11th Street
NYC, NY 10011

7/1/02- 8/1/03 Attending and Chief, Child Neurology

Metropolitan Hospital Center
New York, NY
Curriculum Vitae 3 Dr. Rosario R. Trifiletti

7/1/02- 9/1/03 Attending and Chief, Child Neurology

The New York Foundling Hospital
New York, NY

9/1/03-11/17/07 Chief, Division of Child Neurology

Department of Neurosciences
UMDNJ/Newark
Newark, NJ

4/9/07-7/1/09 Staff Pediatrician and Neurologist

Morristown Memorial and Overlook Hospitals
Atlantic Health System
Morristown, NJ

7/1/09-present Private Child Neurology Practice

246 N. Franklin Tpke, Suite 5 Ramsey, NJ

Awards/Honors
Valedictorian, St.Joseph's Regional High School, 1975.
Salutatorian, Seton Hall University, 1979.
Sigma Xi Research Award, Seton Hall University, 1979.
Paul Ehrlich Award in Basic Science Research, Johns Hopkins University School of Medicine, 1985.
Alpha Omega Alpha (inducted 1986).
Dana Fellow 1990-92.
Finalist, The John Merck Foundation for Developmental Disabilities in Children, 1991.
Fellow, The John Merck Foundation for Developmental Disabilities in Children, 1992-1996.
Florence and Herbert Irving Clinical Research Fellow (Columbia-Presbyterian)1992-1994.
Stanley H. Bergen Award for Excellence in Medicine (by Seton Hall University), 1995.
Assistant Editor, Neurology Alert 1995-2002t

Publications

1. Trifiletti, R. and P. Ander. Interaction of small ions with sodium deoxyribonucleic acid by self-diffusion studies.
Macromolecules 12: 1197-1203 (1979).

2. Trifiletti, R., A. Snowman and S. Snyder. Barbiturate recognition site on the GABA/benzodiazepine receptor
complex is distinct from the picrotoxinin/TBPS recognition site. Eur J Pharmacol 106: p441-447 (1984).

3. Trifiletti, R., A. Snowman and S. Snyder. Solubilization and anionic regulation of cerebral sedative/convulsant
receptors labeled with [35S] tert-butylbicyclophosphorothionate (TBPS). Biochem Biophys Res Commun 120:
p692-699 (1984).

4. Trifiletti, R., M. Lo and S. Snyder. Kinetic differences between type I and type II benzodiazepine receptors.
Mol Pharmacol 26: p228-240 (1984).

5. Trifiletti, R. and S. Snyder. Anxiolytic cyclopyrrolones zopiclone and suriclone bind to a novel site linked
allosterically to benzodiazepine receptors. Mol Pharmacol 26: p458-469 (1984).

6. Trifiletti, R., A. Snowman and S. Snyder. Anxiolytic cyclopyrrolone drugs allosterically modulate the binding of
[35S]t-butylbicyclophosphorothionate to the benzodiazepine/gamma-aminobutyric acid-A receptor/chloride
anionophore complex. Mol Pharmacol 26: p470-476 (1984).

7. Trifiletti, R. and S. Snyder. Localization of type I benzodiazepine receptors to postsynaptic densities in bovine
brain. J Neurosci 5: p1049-1057 (1985).
Curriculum Vitae 4 Dr. Rosario R. Trifiletti

Publications (cont'd)

8. Pevsner, J., R. Trifiletti, S. Strittmatter and S. Snyder. Isolation and characterization of an olfactory receptor
protein for odorant pyrazines. Proc Natl Acad Sci U S A 82: p3050-3054 (1985).

9. Whitehouse, P., R. Trifiletti, B. Jones, S. Folstein, D. Price, S. Snyder and M. Kuhar. Neurotransmitter
receptor alterations in Huntington's disease: autoradiographic and homogenate studies with special reference to
benzodiazepine receptor complexes. Ann Neurol 18: p202-210 (1985).

10. Frost, J., H. J. Wagner, R. Dannals, H. Ravert, A. Wilson, J. Links, A. Rosenbaum, R. Trifiletti and S. Snyder.
Imaging benzodiazepine receptors in man with [11C]suriclone by positron emission tomography. Eur J Pharmacol
122: p381-383 (1986).

11. Snyder, S., A. Verma and R. Trifiletti. The peripheral-type benzodiazepine receptor: a protein of
mitochondrial outer membranes utilizing porphyrins as endogenous ligands. FASEB J 1: p282-288 (1987).

12. Trifiletti, R., A. Snowman, P. Whitehouse, K. Marcus and S. Snyder. Huntington's disease: increased
number and altered regulation of benzodiazepine receptor complexes in frontal cerebral cortex. Neurology 37:
p916-922 (1987).

13. De Vivo, D., R. Trifiletti, R. Jacobson, G. Ronen, R. Behmand and S. Harik. Defective glucose transport
across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay
[see comments]. N Engl J Med 325: p703-709 (1991).

14. Trifiletti, R. Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat. Eur J
Pharmacol 218: p197-198 (1992).

15. Trifiletti, R. and M. Pranzatelli. ACTH binds to [3H]MK-801-labelled rat hippocampal NMDA receptors. Eur J
Pharmacol 226: p377-379 (1992).

16. McEnery, M., A. Snowman, R. Trifiletti and S. Snyder. Isolation of the mitochondrial benzodiazepine
receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl
Acad Sci U S A 89: p3170-3174 (1992).

17. Kader, A., V. Frazzini, R. Solomon and R. Trifiletti. Nitric oxide production during focal cerebral ischemia in
rats. Stroke 24: p1709-1716 (1993).

18. Kader, A., V. Frazzini, C. Baker, R. Solomon and R. Trifiletti. Effect of mild hypothermia on nitric oxide
synthesis during focal cerebral ischemia. Neurosurgery 35: p272-277; discussion 277 (1994).

19. Babey, A., Y. Kolesnikov, J. Cheng, C. Inturrisi, R. Trifiletti and G. Pasternak. Nitric oxide and opioid
tolerance. Neuropharmacology 33: p1463-1470 (1994).

20. Parano, E., R. Falsaperla, V. Pavone and R. Trifiletti. Congenital muscular dystrophy with syringomyelia.
Pediatr Neurol 11: p263-265 (1994).

21. Parano, E., A. Fiumara, R. Falsperla, G. Vita and R. Trifiletti. Congenital muscular dystrophy: correlation of
muscle biopsy and clinical features. Pediatr Neurol 10: p233-236 (1994).

22. Vosatka, R., S. Kashyap and R. Trifiletti. Arginine deficiency accompanies persistent pulmonary
hypertension of the newborn. Biol Neonate 66: p65-70 (1994).

23. Parano, E., L. Pavone, A. Fiumara, R. Falsaperla, R. Trifiletti and W. Dobyns. Congenital muscular
dystrophies: clinical review and proposed classification. Pediatr Neurol 13: p97-103 (1995).
Curriculum Vitae 5 Dr. Rosario R. Trifiletti

Publications (cont'd)

24. Parano, E., R. Falsaperla, V. Pavone, A. Toscano, E. Bolan and R. Trifiletti. Intrafamilial phenotypic
heterogeneity of the Poland complex: a case report. Neuropediatrics 26: p217-219 (1995).

25. DeVivo, D., M. Garcia-Alvarez, G. Ronen and R. Trifiletti. Glucose transport protein deficiency: an emerging
syndrome with therapeutic implications. Int Peds 10: 1 (1995).

26. Trifiletti, R., G. Incorpora, A. Polizzi, M. Cocuzza, E. Bolan and E. Parano. Aicardi syndrome with multiple
tumors: a case report with literature review. Brain Dev 17: p283-285 (1995).

27. Trifiletti, R., E. Parano, R. Falsaperla and G. Incorpora. Myotonic dystrophy in a large Sicilian kinship: a case
report. Childs Nerv Syst 11: p453-455 (1995).

28. Trifiletti, R., R. Falsaperla, A. Fiumara, E. Parano and L. Pavone. Mental retardation in muscular dystrophy:
a study from Catania, Italy with a review of the literature. Dev Brain Dysfunct 7: 183-191 (1995).

29. Parano, E., A. Uncini, G. Incorpora, V. Pavone and R. Trifiletti. Delayed bilateral median nerve injury due to
low-tension electric current. Neuropediatrics 27: p105-107 (1996).

30. Harden, C., R. Trifiletti and H. Kutt. Felbamate levels in patients with epilepsy. Epilepsia 37: p280-283
(1996).

31. Incorpora, G., L. Pavone, E. Parano, M. Cocuzza, F. Catalano and R. Trifiletti. Neurological complications in
hospitalized patients with pertussis: a 15-year Sicilian experience. Childs Nerv Syst 12: p332-335 (1996).

32. Barbut, D., J. Gold, M. Heinemann, R. Hinton and R. Trifiletti. Horner's syndrome after coronary artery
bypass surgery. Neurology 46: p181-184 (1996).

33. Barbut, D., F. Yao, D. Hager, P. Kavanaugh, R. Trifiletti and J. Gold. Comparison of transcranial Doppler
ultrasonography and transesophageal echocardiography to monitor emboli during coronary artery bypass surgery.
Stroke 27: p87-90 (1996).

34. Parano, E., L. Pavone, S. Musumeci, F. Giambusso and R. Trifiletti. Acute palsy of the recurrent laryngeal
nerve complicating Epstein-Barr virus infection. Neuropediatrics 27: p164-166 (1996).

35. Parano, E., L. Pavone, R. Falsaperla, R. Trifiletti and C. Wang. Molecular basis of phenotypic heterogeneity
in siblings with spinal muscular atrophy. Ann Neurol 40: p247-251 (1996).

36. Yao, F., D. Barbut, D. Hager, R. Trifiletti and J. Gold. Detection of aortic emboli by transesophageal
echocardiography during coronary artery bypass surgery. J Cardiothorac Vasc Anesth 10: p314-317 (1996).

37. Barbut, D., F. Yao, Y. Lo, R. Silverman, D. Hager, R. Trifiletti and J. Gold. Determination of size of aortic
emboli and embolic load during coronary artery bypass grafting [see comments]. Ann Thorac Surg 63: p1262-
1267 (1997).

38. Donovan, G., C. Harden, J. Gal, L. Ho, E. Sibille, R. Trifiletti, L. Gudas and M. Toth. Sensitivity to jerky gene
dosage underlies epileptic seizures in mice. J Neurosci 17: p4562-4569 (1997).

39. Barbut, D., Y. Lo, J. Gold, R. Trifiletti, F. Yao, D. Hager, R. Hinton and O. Isom. Impact of embolization
during coronary artery bypass grafting on outcome and length of stay. Ann Thorac Surg 63: p998-1002 (1997).
Curriculum Vitae 6 Dr. Rosario R. Trifiletti

Publications (cont'd)

40. Barbut, D., Y. Lo, G. Hartman, F. Yao, R. Trifiletti, D. Hager, R. Hinton, J. Gold and O. Isom. Aortic atheroma
is related to outcome but not numbers of emboli during coronary bypass. Ann Thorac Surg 64: p454-459 (1997).

41. Bernardini, G., D. Herrera, D. Carson, G. R. De, S. M. Gama, E. Kolodny and R. Trifiletti. Adult-onset
Krabbe's disease in siblings with novel mutations in the galactocerebrosidase gene. Ann Neurol 41: p111-114
(1997).

42. Ara, J., S. Przedborski, A. Naini, V. Jackson-Lewis, R. Trifiletti, J. Horwitz and H. Ischiropoulos. Inactivation
of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine (MPTP). Proc Natl Acad Sci U S A 95: p7659-7663 (1998).

43. Parano, E., V. Pavone, F. Greco, M. Majorana and R. Trifiletti. Reflex sympathetic dystrophy associated with
deep peroneal nerve entrapment. Brain Dev 20: p80-82 (1998).

44. Parano, E., S. Giuffrida, D. Restivo, R. Saponara, F. Greco and R. Trifiletti. Reversible palsy of the
hypoglossal nerve complicating infectious mononucleosis in a young child. Neuropediatrics 29: p46-47 (1998).

45. Calingasan, N., L. Park, L. Calo, R. Trifiletti, S. Gandy and G. Gibson. Induction of nitric oxide synthase and
microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. Am J
Pathol 153: p599-610 (1998).

46. Incorpora, G., P. Pavone, N. Platania, R. Trifiletti and E. Parano. Vein of Galen malformation and infantile
spasms. J Child Neurol 14: p196-198 (1999).

47. Incorpora, G., G. F. Di, M. Romeo, P. Pavone, R. Trifiletti and E. Parano. Focal neurological deficits in
children with beta-thalassemia major. Neuropediatrics 30: p45-48 (1999).

48. Parano, E., V. Pavone, F. DiGregorio and R. Trifiletti. Extraordinary intrathecal bone reaction in b-
thalassemia intermedia. Lancet 354: 922 (1999).

49. Pavone, P., R. Garozzo, R. Trifiletti and E. Parano. Marin-Amat syndrome: case report and review of the
literature. J Child Neurol 14: p266-268 (1999).

50. Incorpora G, Pavone P, Smilari PG, Trifiletti R, Parano E. Late primary unilateral thalamic hemorrhage in
infancy: report of two cases. Neuropediatrics 30(5):264-7 (1999).

51. Pavone, P., E. Parano, A. Polizzi, and R.R. Trifiletti, Colobomatous microphthalmia, microcephaly with
cerebellar hypoplasia: association or new syndrome? Am J Med Genet, 92(4): p. 278-80 (2000).

52. Bolan, E.A., K.N. Gracy, J. Chan, R.R. Trifiletti, and V.M. Pickel, Ultrastructural Localization of Nitrotyrosine
within the Caudate-Putamen Nucleus and the Globus Pallidus of Normal Rat Brain. J Neurosci, 20(13): p. 4798-
480 (2000).

53. Barone R, Pavone P, Trifiletti RR, Parano E. Tuberous breast deformity in an adolescent girl with Hurler-
Scheie syndrome. Eur J Pediatr 159(12): 936-7 (2000).

54. Parano E, Trifiletti RR, Barone R, Pavone V, Pavone P. Arthrogryposis multiplex congenita and pituitary
ectopia. A case report. Neuropediatrics 31(6):325-7 (2000)

Publications (cont'd)
Curriculum Vitae 7 Dr. Rosario R. Trifiletti

55. Trifiletti RR, Restivo DA, Pavone P, Giuffrida S, Parano E. Diabetes insipidus in neurobrucellosis. Clin Neurol
Neurosurg 102(3):163-5 (2000).

56. Parano E, Falcidia E, Grillo A, Pavone P, Cutuli N, Takabayashi H, Trifiletti RR, Gilliam CT. Noninvasive
prenatal diagnosis of chromosomal aneuploidies by isolation and analysis of fetal cells from maternal blood. Am J
Med Genet Jul 1;101(3):262-7 (2001).

57. Parano E, Falcidia E, Grillo A, Takabayashi H, Trifiletti RR, Pavone P. Fetal nucleated red blood cell counts
in peripheral blood of mothers bearing Down syndrome fetus. Neuropediatrics 32(3):147-9 (2001)

58. Pavone P, Bianchini R, Trifiletti RR, Incorpora G, Pavone A, Parano E. Neuropsychological assessment in
children with absence epilepsy. Neurology 56(8):1047-51 (2001).

59. Greco F, Finocchiaro M, Pavone P, Trifiletti RR, Parano E. Hemihydranencephaly: case report and literature
review. J Child Neurol 16(3):218-21 (2001)

60. Barone R., Parano E, Trifiletti RR, Fiumara A and P. Pavone. White matter changes mimicking a
leukodystrophy in a patient with Mucopolysaccharidosis: characterization by MRI.
J Neurol Sci. 30:195:171-5 (2002).

61. Pavone P, Bianchini R, Parano E, Incorpora G, Rizzo R, Mazzone L, Trifiletti RR. Anti-brain antibodies in
PANDAS versus uncomplicated streptococcal infection. Pediatr Neurol.30(2):107-10 (2004).

62. Falcidia E, Parano E, Grillo A, Pavone P, Takabayashi H, Trifiletti RR, ScolloP, Dallapiccola B, Grammatico
P, Novelli A, Paladini D, Monni G, Gulisano A,Scassellati G. Fetal cells in maternal blood: a six-fold increase in
women who have undergone amniocentesis and carry a fetus with Down syndrome: a multicenter study.
Neuropediatrics. 2004 Dec;35(6):321-4

63. Pavone P, Incorpora G, Fiumara A, Parano E, Trifiletti RR, Ruggieri M. Epilepsy is not a prominent feature of
primary autism. Neuropediatrics. 2004 Aug;35(4):207-10.

64. Pavone P, Barbagallo M, Parano E, Pavone L, Souayah N and Trifiletti RR Clinical heterogeneity in familial
congenital ptosis: analysis of fourteen cases in one family over five generations. Pediatr Neurol 33: 251-4 (2005)

65. Pavone P, Parano E, Trifiletti RR Autoimmune neuropsychiatric disorders associated with streptococcal
infection: Sydenham chorea, PANDAS and PANDAS variants. J Child Neurol . 2006 Sep;21(9):727-36 (2006).

66. Trifiletti RR,, Hosain, Syed E, Hayes-Rosen C, Parano E., MD and *Pavone P., MD Anton-Babinski
syndrome in a child with early-stage adrenoleukodystrophy. In press, J Child Neurol (2007).

67. Pavone P, Ruddle JB, Parano E, Trifiletti RR amd Mackey DA. Levator-Abducens Synkinesis: A clinical sign
associated with familial congenital ptosis. Submitted, Eur J Ped Neurol, 2008.

68. Pavone P, Parano E, Trifiletti RR Levator-Abducens Synkinesis: A clinical sign associated with congenital
ptosis In press, Neurology (2007)

69. Trifiletti RR , Parano E and P. Pavone Familial early-onset dystonic-gutteral tics: A PANDAS Variant ?
Submitted, J. Child. Neurol, 2008.

70. Trifiletti RR and P. Pavone. Displacement mutism: a novel anxiety disorder . Submitted, J Child Adol Psych,
2008.

.
Publications (cont’d)
Curriculum Vitae 8 Dr. Rosario R. Trifiletti

71. Pavone P., R Falsaperla S Leonardi, R Taibi and RR Trifiletti. Arterial ischemic stroke complicating
infectious disease in children with Down syndrome and selective IgG4 subclass deficiency. Submitted, J Child
Neurol 2008

72. Pavone P, Parano E ,Rizzo R. And RR Trifiletti. Elevated Streptococcal antibody titers are associated with
presence of anti-neuronal antibodies in patients with Tourette syndrome but not uncomplicated streptococcal
infection. Submitted, Pediatrics, 2008.

73. Pavone V, Privitera V, Costarella L, Pavone P, Trifiletti RR, Sessa G. Bilateral total hip arthroplasty in
subjects with multiple epiphyseal dysplasia. Submitted Int J Ped Orthoped, 2008

74. Trifiletti RR. Behavioral exacerbations in autistic patients associated with streptococcal infection. Submitted,
J Child Neurol, 2009.

75. Trifiletti RR. Developmental regression and mitochondrial dysfunction in a male with selective MeCP2
duplication. Submitted Ped Neurol 2009.

76. Trifiletti RR. Oromotor apraxia and autistic-like features associated with LIS1 overexpression. Submitted,
Neurol 2009

77. Trifiletti RR Selective and displacement mutism in Williams-Beuren duplication syndrome. Submitted, Ped
Neurol, 2009.

78. Trifiletti RR. Selective duplication of serotonin receptor gene HTR1B/D associated with severe anxiety over
two generations. Submitted, J Child Adol Psych 2009

79. Trifiletti RR. Exorcist syndrome: a severe PANDAS variant. Submitted, J Child Neurol.

80. Trifiletti RR. Neurexin-1 deficiency associated with a autism and severe self-injurious behaviour.

81. Trifiletti RR. Marfanoid features and unusual general anesthetic reaction in a 47-XXX female. Submitted Ped
Anesthesia

Review Articles

1. Snyder,S.H. and R.R.Trifiletti. Drug and synaptic principles elucidated by GABA and benzodiazepines.
Biogenic Amines 5,no.3/4,191-197(1988).

2. Trifiletti, R.R. and F.M. Testa. A practical approach to childhood head injury. Emergency Peds. 4:72-74
(1991).

3. Trifiletti, R.R. and A.M. Packard. Metabolic disorders presenting with behavioral symptoms in the school-aged
child. Child Adolesc Psychiatr Clin N Am 8:767, 1999

4. Trifiletti RR, Packard AM: Immune mechanisms in pediatric neuropsychiatric disorders. Tourette's syndrome,
OCD, and PANDAS. Child Adolesc Psychiatr Clin N Am 8:767, 1999

Book Articles
Curriculum Vitae 9 Dr. Rosario R. Trifiletti

1. Lo,M.M.S., Trifiletti,R.R. and S.H.Snyder. Physical separation and characterization of two central
benzodiazepine receptors. In: Pharmacology of the Benzodiazepines Edited by E.Usdin, P.Skolnick, J.F.Tallman
Jr., D.Greenblatt and S.M.Paul. Raven Press,165-172(1982).

2. Singer,H.S., Trifiletti,R.R. and K.Gammon. The role of "other" neuroleptic drugs in the treatment of
Tourette's Syndrome. In: Tourette's Syndrome and Tic Disorders-Clinical Understanding and Treatment Edited by
D.J.Cohen, R.D.Bruun and J.F.Leckman, Wiley-Interscience, 304-316 (1988).

3. Trifiletti, R.R. and D.R. Nordli. Hyperammonemia. Chap.83 in Merritt's Textbook of Neurology, 9th ed.
Lea and Fibiger (1996).

4. Chutorian, A.M. and R.R. Trifiletti. Vitamins and Electrolytes, Ch.55 in Priniciples of Child Neurology, in
B.Berg (ed). 1996

5. Pavone, P. and R. Trifiletti. Chorea Minor Sydenham, Ch. 321 in Encyclopedia of Molecular Mechanisms
of Disease. Springer, Berlin (2008).

Abstracts

1. Trifilettti,R.R.,Lo,M.M.S. and S.H.Snyder. Central benzodiazepine (BZ) receptors: heterogeneity and

cooperativity in receptor subpopulations. Soc.Neuroscience Abstr.,Vol.8,p.573(1982).

2. Trifiletti,R.R. and S.H.Snyder. Partial proteolytic mapping of the benzodiazepine binding subunit of
central benzodiazepine receptors. Soc.Neurosci.Abstr., Vol.9,p.403(1983).

3. Nye,J.S., Blaustein,R.O., Trifiletti,R.R. and S.H.Snyder. Cyclopyrrolone anxiolytics allosterically influence

benzodiazepine receptor binding at a novel allosteric site. Soc.Neurosci.Abstr. Vol.9, p.404(1983).

4. Trifiletti,R.R. and S.H.Snyder. Cyclopyrrolone anxiolytics allosterically influence benzodiazepine receptor

binding. (Presented,Symposium on Cyclopyrrolones, XIV C.I.N.P. Conference Florence,Italy). Clin.
Neuropharmacol. Vol.7,Suppl.1,624-625(1984).

5. Trifiletti,R.R., Snowman,A.M. and S.H.Snyder. Specific effects of shortwave ultraviolet radiation on the
anion recognition site of benzodiazepine/GABA receptors. Soc.Neurosci.Abstr.,Vol.10,p.970 (1984).

6. Frost,J.J., Dannals,R.F., Ravert,H.T., Wilson,A.A., Links, J.M., Trifiletti,R.R., Kuhar,M.J., Snyder,S.H.

and H.N.Wagner. Imaging benzodiazepine receptors in man with [11C]suriclone and positron emission
tomography. Soc.Neurosci Abstr,,Vol.11,p.1121 (1985).

7. Trifiletti,R.R., Verma,A. and S.H.Snyder. Molecular identification of peripheral-type benzodiazepine

receptors. Soc.Neurosci.Abstr.,Vol.12,p.666 (1986).

8. Verma,A. Trifiletti,R.R., Michael,E.M., and S.H.Snyder. Peripheral-type benzodiazepine receptors:

Porphyrins as endogenous ligands: hormonal associations. Soc.Neurosci.Abstr.,Vol.13,p.965 (1987).

9. Trifiletti,R.R. and M.R.Pranzatelli. Central benzodiazepine receptor changes in the p,p'-DDT

myoclonic/epileptic rat hippocampus. Soc.Neurosci.Abstr.,Vol.15, p.1073 (1989).

Abstracts (cont’d)
Curriculum Vitae 10 Dr. Rosario R. Trifiletti

10. Trifiletti, R.R. and M.R. Pranzatelli. The peripheral benzodiazepine receptor in childhood
neuroectodermal tumors. Neurology 40(Suppl. 1) 361 (1990).

11. DeVivo, D.C., Trifiletti,R.R., Jacobson,R.I. and S.I. Harik. Glucose transporter deficiency causing
persistent hypoglychorrhachia: a unique cause of infantile seizures and acquired microcephaly. Ann. Neurol.
28:414(1990).

12. Trifiletti,R.R. and M.R. Pranzatelli. Influence of ACTH and ACTH fragments on (3H)MK-801 binding to
rat hippocampal NMDA receptors. Soc.Neurosci Abstr., Vol.16,p.785 (1990).

13. Trifiletti,R.R., Testa,F.M., Gold,A.P. and D.C. DeVivo. Partial remission of subacute sclerosing
panencephalitis (SSPE) with intrathecal alpha-interferon therapy. Ann.Neurol. 30:507(1991).

14. D.C. DeVivo and R.R. Trifiletti. Neuronal nitric oxide synthetase (NOS): relationship to NADPH-
diaphorase. Neurology 42:168 (1992).

15. Trifiletti, R.R. Nitric oxide synthetase (NOS) - a neuronal oxygen sensor candidate. Neurology 42: 69
(1992).

16. D.C. DeVivo and R.R. Trifiletti. Neuronal nitric oxide synthetase (NOS): relationship to NADPH-
diaphorase. Neurology 42:168 (1992).

17. Trifiletti, R.R. Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat pup. Ann.
Neurol. 32:461(1992).

18. Wang, C.H., Trifiletti, R.R., Gold, A.P. and D.C. DeVivo. Plasma exchange versus intravenous
immunoglobulin as treatment for childhood-onset Guillain-Barré syndrome. Ann. Neurol. 32:440 (1992).

19. Trifiletti, R.R., Kader, A. and R.Solomon. Brain nitric oxide production in focal ischemia.
Soc.Neurosci Abstr., Vol.18,p.1254 (1992).

20. Kader,A., Trifiletti,R.R., Solomon,R. and R.R.Goodman. Mild hypothermia: effect on infarct size and
brain nitric oxide production. Soc.Neurosci Abstr., Vol.18, p.1587 (1992).

21. Kader,A., Solomon .R. and R.R.Trifiletti. Nitric oxide production during focal cerebral ischemia.
Presented, 18th International Joint Conference on Stroke and Cerebral Circulation. Miami,Fla. (1993).
Abstracts (cont’d)

22. Trifiletti, R.R. and E.Bolan. Nitric oxide mediates 3-nitropropionic acid neurotoxicity. Neurology 43:A329
(1993).

23. Trifiletti, R.R. and D.C. DeVivo. Erythrocyte glucose transport in the blood-brain barrier glucose
transporter deficiency syndrome. Ann. Neurol. 34:316 (1993)

24. Trifiletti, R.R. Macaya, A. and E.Bolan. Nitric oxide mediates quinolinate neurotoxicity in the rat pup. Ann.
Neurol. 34:444 (1993).

25. Trifiletti, R.R. and E.Bolan. Quantitative analysis of spontaneous developmental myoclonus in the rat
pup. Ann. Neurol. 34:491(1993).
Curriculum Vitae 11 Dr. Rosario R. Trifiletti

Abstracts (cont’d)

26. Trifiletti, R.R. and E. Bolan. Possible physiologic role for nitric oxide in the developing rat brain:
myoclonic facilitation. Soc. Neurosci. Abstr., Vol. 19, p.754 (1993).

27. Kolesnikov, Y., Babey, A.M., Cheng, J., Trifiletti, R.R. and G.W. Pasternak. Blockade of morphine
tolerance by nitric oxide synthase inhibitor: behavioral and biochemical data. Soc. Neurosci. Abstr., Vol. 19,
p.1797 (1993).

28. Parano E, Falsaperla R, Fiumara A, Trifiletti R. Mental retardation in Duchenne-Becker muscular

dystrophy. Abstract XXIV Congress of the International Society of Psychoneuroendocrinology. Taormina 19-23
Settembre 1993. Neur Endocrinol Letters 15:330 (1993).

29. Bolan, E. and Trifiletti, R.R. Post-hypoxic myoclonus: a rat pup model. Neurology 44 (Suppl.2), p. A305
(1994).

30. Garcia-Alvarez, M., DeVivo, D.C. and R. Trifiletti. CSF diagnosis of blood-brain barrier glucose
transporter deficiency. Neurology 44 (Suppl.2), p. A208 (1994).

31. Trifiletti, R.R., Bolan, E.A., Lynch, T., Lovelace, R., Côte, L., Pullman, S. and S.Fahn. Quantitative
stochastic analysis of myoclonic movements in a patient with Whipple's disease. Presented, Eight annual
symposim on Etiology, Pathogenesis and Treatment of Parkinson's disease and on Hyperkinetic Movement
Disorders, San Francisco, CA., Oct. 9, 1994.

32. Bandele, A.N., Bolan, E.A. and R.R Trifiletti. Excitotoxic injury impairs mitochondrial respiratory chain
function in the neonatal rat pup by a nitric oxide dependent mechanism. Ann. Neurol 36: 533 (1994).

33. Garcia-Alvarez, M., D.C.DeVivo and R.R. Trifiletti. CSF findings in infants evaluated for possible sepsis.
Ann. Neurol 36: 533 (1994).

34. Garcia-Alvarez, M., R.R. Trifiletti and D.C.DeVivo. Cerebrospinal fluid (CSF) glucose and lactate values
in neurometabolic diseases. Ann. Neurol 36: 467 (1994).

35. DeVivo, D.C., Burke, C., Trifiletti, R., Filloux, F, Dooley, J., Sherwood, G., Garcia-Alvarez,M. and S.I.
Harik. Glucose trasporter protein deficiency: an emerging syndrome with therapeutic implications. Ann.Neurol
Abstracts (cont’d)

36: 481 (1994).

36. Kader, A., Solomon R., Bolan, EA, Gubits R and R.R.Trifiletti. The effect of N-acetylcysteine on infarct
size and nitric oxide production during focal cerebral ischemia. Soc. Neurosci. Abstr., Vol. 20, p.190 (1994).

37. Trifiletti, RR, Bolan, EA and A.N. Bandele. Tyrosine nitration in the nervous system. In: Nitric Oxide:
Advances in Therapeutic Application and Commercial Development. International Business Communications.
Scarborough, MA (1995).

38. Trifiletti R.R., Bolan E.A. and A.N Bandele. Protection against excitotoxic injury in rat pups by
glutathione and N-acetylcysteine. Ann. Neurol 38: 504 (1995).

Abstracts (cont’d)
Curriculum Vitae 12 Dr. Rosario R. Trifiletti

39. Trifiletti R.R, Bolan E.A. and A.N. Bandele. Protein tyrosine nitration in the developing nervous system: a
marker of brain nitric oxide production. Ann. Neurol 38: 523 (1995).

40. Trifiletti R.R. and E. A. Bolan Effects of body temperature upon myoclonus in a rat pup model. Ann.
Neurol 38: 524 (1995).

41 Incorpora G., Parano E. and R.R.Trifiletti. Pertussis and neurological complications: a fifteen year
Sicilian experience. Ann. Neurol 38: 524 (1995).

42. Trifiletti RR, Solomon GE, Pons R, and D.C. DeVivo. Dicarboxylic aciduria in Bannayan-Riley-Ruvalcaba
syndrome: a case report. Presented at 24th annual Child Neurology Society meeting, 1995.

43. Bernardini G.L, Herrera D., Carson D. and R.R. Trifiletti. Pure motor adult-onset Krabbe disease in
affected siblings: a case report. Presented at 24th annual Child Neurology Society meeting, 1995

44. Trifiletti R.R., Bandele, A.N. and E. A. Bolan. Protein tyrosine nitration in the nervous system: a marker
of brain nitric oxide production. Soc. Neurosci. Abstr., Vol. 21, p.869 (1995).

45. Trifiletti R.R.,Toth M. and C.L. Harden. Chronometric analysis of recurrent seizures: a formalism for
analysis of seizure “clustering”.Epilepsia 36 (Supp 4) 63 (1995)

46. Harden C.L.,Toth, J.L., Trifiletti R.R. and M. Toth. Marked increase in pentylenetetrazol-provoked
seizures in a novel null-allele transgenic mouse model. Epilepsia 36 (Supp 4) 121 (1995)
Abstracts (cont’d)

47. Filipov, P., Roth, P., Koenigsberg M. and R.R. Trifiletti. Measurement of nitrite/nitrate levels in
cerebrospinal fluid (CSF) of preterm babies: relationship to brain damage. Presented, Eastern Society for
Pediatric Research, New Brunswick, NJ, Jan 24, 1996.

48. Hills, D.F., Apatoff, B.R. and R.R. Trifiletti .Protein tyrosine nitration and anti-nitrotyrosine antibodies in
patients with multiple sclerosis. In: Nitric Oxide: Moving toward the clinic International Business Communications.
Scarborough, MA (1996).

49. Ngyuen, K., J.Wagner and R.R. Trifiletti. Nitric oxide stimulates endogenous biotinylation of proteins in
neuronal cell lines. Presented, at Biochemistry and Molecular Biology of Nitric Oxide: An International
Conference. University of California, Los Angeles, July 13-17 (1996).

Abstracts (cont’d)

50. Yao, F.S, Barbut D., Lo, T., Trifiletti RR, Hartman G and J. Gold. Aortic emboli detected by
transesophageal echocardiography do not correlate with severity of aortic atheromatous disease. Presented,,
American Society of Anesthesiology, 1996.

51. Trifiletti R. Neurologic causes of progressive cognitive decline in childhood. Presented,, American
Academy of Child Psychiatry, Philadelphia, October 1996.

52. Trifiletti R.R., Lazar, L., Bojko, A., Chutorian, A.M. and S. DiMauro. Early poliodystrophy with
mitochondrial defect (EPMD): two cases. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis,
September, 1996.

53. Filipov, P., Hills, D.F. and R.R. Trifiletti. CSF nitrite/nitrate in normal neonates and those with IVH.
Presented, 25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

Abstracts (cont’d)
Curriculum Vitae 13 Dr. Rosario R. Trifiletti

54. Trifiletti R.R., Pavone, L., Incorpora, G., E. Parano. Stroke in children with β -thalassemia: role of
hypertransfusion. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

55. Trifiletti R.R., Pavone, P. and E. Parano. Acute palsy of the recurrent laryngeal nerve and Epstein-Barr
virus infection. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

56. Trifiletti R.R., Harden, C., Incorpora, G. and Parano, E. Recurrent afebrile seizures in children initially
diagnosed with febrile seizures. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis,
September, 1996.

57. Ngyuen, K., Wagner, J. and R.R. Trifiletti. Multitude of biotinylated proteins in neural cells: alteration by
oxidative stress. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

58. Hills, D.F., Filipov, P. and R.R. Trifiletti. CSF protein tyrosine nitration in neonates: marker of brain NO
production. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

59. Takai, E., Hills, D.F., Bandele, A.N. and R.R. Trifiletti. Marked enhancement of protein tyrosine nitration
by dystonia-producing toxin 3-nitropropionic acid (3-NP): implications for mechanisms of neurotoxicity. Presented,
25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

60. Parano, E. and R.R.Trifiletti. Reflex sympathetic dystrophy associated with deep peroneal nerve
entrapment. Presented, 25th Annual Child Neurology Society Meetings. Minneapolis, September, 1996.

61. Bernardini, G.L, Herrera, D.G., Carson, D., DeGasperi, R.G., GamaSosa M.A., Kolodny, E.H. and R.R.
Trifiletti. Late onset Krabbe disease in GALC compound heterozygotes. Presented, 25th Annual Child Neurology
Society Meetings. Minneapolis, September, 1996.

62. Bolan, E.A., Trifiletti, R.R. and V. Pickel. Nitrotyrosine immunolabelling present in axons and glial
processes in the globus pallidus of normal adult rat brain. Soc. Neurosci. Abstr., Vol. 22, p.891 (1996)

63. Trifiletti R.R., Harden, C.L., Toth, J.G. and M. Toth. Effect of genetic background on PTZ-provoked
seizures in the jerky mouse model. Epilepsia, 37 (Supp 5), p.77 (1996).

64. Yao, F.S., Barbut, D., Hager, D.N., Trifiletti R.R. and J.P. Gold. Comparison of transcranial doppler
and transesophageal echocardiography to monitor emboli during coronary artery bypass surgery.
Anesth. Analg. 82: SCA61 (1996).

65. Yao, F.S., Barbut, D., Hager, D.N., Trifiletti R.R. and J.P. Gold. Determination of embolic size and
load of embolization with transesophageal echocardiography during coronary artery bypass surgery.
Anesth. Analg. 82: SCA62 (1996).

66. Ngyuen, K., Wagner, J. and R.R. Trifiletti. Nitric oxide stimulates endogenous protein biotinylation in
neuronal cell lines. Presented 16th Annual Vincent du Vigneau Medical Research Symposium. New York May,
1996.

67. Gold, J.P., Barbut, D., Lo, T., Trifiletti, R.R., Yao, F.S., Hager, Hinton, D.N. and O.W.Isom. The impact of
cerebral emboli during coronary bypasss surgery on neurologic and cardiac outcomes as well as length of
hospital stay. Presented, Soc. Thor. Surg, 1997.

68. Przedborski S, Kostic, V., Jackson-Lewis, Bandele A.N. and R. R. Trifiletti. Nitrotyrosine and
Parkinson’s disease. Neurology 48, A201 (1997).

Abstracts (cont’d)
Curriculum Vitae 14 Dr. Rosario R. Trifiletti

69. Delanty, N., Przedborski, S., Bandele, A..N., Lynch, T. aand Rosario R. Trifiletti. Elevated protein
nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis Neurology 48, A201 (1997).

70. Bojko, A., Frucht, S., Eidelberg, D, Nygaard, T., Trifiletti, R. and A.M. Chutorian. ARA-C induced
parkinsonism in a child: case report. Presented , Iberian Neurological Society (1997).

71. Frucht, S., Zabriskie, J. and R. R. Trifiletti. Immunoblot characterization of anti-neuronal antibody targets
in Sydenham chorea. Presented,, 26th Annual Meeting Child Neurology Society, Phoenix, Ariz., October 1997.

72. Nguyen, K., Wagner, J. and R.R. Trifiletti.. Induction of endogenous protein biotinylation after oxidative
stress involves multiple intracellular signaling pathways… Presented,, 26th Annual Meeting Child Neurology
Society, Phoenix, Ariz., October 1997.

73. Bojko, A.S., Chutorian, A.M., Eidelberg, D., Frucht, S.J., Nygaard, T., Trifiletti, R.R. and L. Heier. MPTP-
like parkinsonism secondary to ARA-C: neurochemical and PET findings. Presented,, 26th Annual Meeting Child
Neurology Society, Phoenix, Ariz., October 1997.

74. Trifiletti, RR, Toth M and C.L. Harden. Genetic control of seizure clustering in the jerky mouse.
Presented,, American Epilepsy Society, 1997.

75. Harden, C.L., Jacobs, A., Trifiletti, R.R. Estrogen use increases incidence of focal seizures in post-
menopausal women. Presented,, American Epilepsy Society, 1997.

76. Trifiletti R.R., Frucht S., Altemus, M., Bandele, A. and J. Zabriskie. TS83: a candidate autoantigen
recognized by the serum of patient with Gilles de la Tourette Syndrome and childhood obsessive
compulsive disorder. Presented,, Soc for Biological Psychiatry, 1998.

77. Trifiletti ,R.R., Altemus ,M., Solomon ,G.R., Packard, A.M. , Bandele, A.N.. and J.B. ZabriskieTS83:
candidate target brain autoantigen in Tourette Syndrome and OCD. Ann. Neurol 44: 561 (1998).

78. Trifiletti R.R., Altemus, M, Packard, A.M., Bandele, A.N. and J.B. Zabriskie. Changes in anti-neuronal
antibodies following conventional and immunosuppressive therapy for Tourette Syndrome and OCD. Ann. Neurol
44: 561 (1998).

79.Trifiletti, R.R. and Packard, A.M. Monozygotic twins with Childhood Disintegrative Disorder (CDD):
evidence for a genetic basis. Ann. Neurol 44: 574 (1998).

80 Trifiletti, R.R. and Solomon, G.E. Bannayan-Riley-Ruvalcaba-Smith syndrome: a “Sotos-like” syndrome

related to Cowden disease. Ann. Neurol 44: 574 (1998).

81 Joshi, C., Engel, M., Solomon, G.E., Chutorian, A.M. and R.R. Trifiletti. Brainstem autoantibodies in a
child with Cogan syndrome. Presented,, 51st Annual Meeting of the American Academy of Neurology,
Toronto, Ontario, Canada, April 1999

82 Trifiletti R.R., Altemus, M. and J. Zabriskie. Antibodies to the Calpain-Calpastatin complex in patients
with Tourette Syndrome and Obsessive Compulsive Disorder. Presented,, Third International Scientific
Symposium on Tourette Syndrome, New York, NY, June 1999.

83 Trifiletti RR. Immunotherapy in pediatric neuropsychiatric disorders. Presented,, 47th Annual Meeting of
the American Academy of Child and Adolescent Psychiatry. New York, NY, October 2000.

Abstracts (cont’d)
Curriculum Vitae 15 Dr. Rosario R. Trifiletti

84 Bianchini R, Pavone P. , Parano E. and R. R. Trifiletti anti-brain antibodies are frequently present in
children with pandas but not uncomplicated active Group A Streptococcal infection. Presented,, 29th
Annual Meeting of the Child Neurology Society, St. Louis, MO, October 2000.

85 Trifiletti R.R. and A. N. Bandele Serum antibodies to specific brain proteins in patients with tics, Tourette
syndrome and/or Obsessive-Compulsive Disorder. Ann Neurol 48: 511-12(2000).

86 Trifiletti R.R. and Bandele, A.N. Antibodies to the calpain-calpastatin complex in patients with Tics,
Tourette syndrome and/or Obsessive compulsive disorder . Ann Neurol 48: 542(2000)

87 Pavone P. , Bianchini R. , Parano E. and R. R. Trifiletti Neuropsychological assessment in children with

absence epilepsy. Presented,, 29th Annual Meeting of the Child Neurology Society, St. Louis, MO,
October 2000.

88 Nguyen K., Bandele, A.N. Wagner, J.A. and R. R. Trifiletti. Resistance to toxicity from glutathione
depletion in a nitric oxide resistant cell line . Presented,, 29th Annual Meeting of the Child Neurology
Society, St. Louis, MO, October 2000.

89. Pavone P., Parano E. , Polizzi A. and R. R. Trifiletti Colobomatous microphthalmia,

microcephaly with cerebellar hypoplasia: a new clinical syndrome Presented,, 29th Annual Meeting of the
Child Neurology Society, St. Louis, MO, October 2000.

90. Trifiletti RR, Lazar LL. “Exorcist syndrome”: a severe PANDAS variant. Presented, 37th Annual Meeting of the
Child Neurology Society. Santa Clara, CA November 2008

91. Pavone P, Parano E ,Rizzo R. And RR Trifiletti. Elevated Streptococcal antibody titers are associated with
presence of anti-neuronal antibodies in patients with Tourette syndrome but not uncomplicated streptococcal
infection. Presented, 37th Annual Meeting of the Child Neurology Society. Santa Clara, CA November 2009