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    Pathophysiology of Multiple Myeloma

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    Rifa'atul Mahmudah
    Multiple myeloma is a cancer of plasma cells that develops due to a combination of predisposing and precipitating factors. Predisposing factors include increasing age, family history of cancer, and having monoclonal gammopathy of uncertain significance. The cancer develops as chromosomes and genes are destroyed, eliminating controls on plasma cell proliferation and antibody secretion. This leads to overproduction of antibodies and immature, proliferating plasma cells spreading through the bone marrow. Consequences include kidney failure, anemia, increased risk of infection, bone lesions, and fatigue.

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    Pathophysiology of Multiple Myeloma

    Uploaded by

    Rifa'atul Mahmudah
    344 views3 pages
    Multiple myeloma is a cancer of plasma cells that develops due to a combination of predisposing and precipitating factors. Predisposing factors include increasing age, family history of cancer, and having monoclonal gammopathy of uncertain significance. The cancer develops as chromosomes and genes are destroyed, eliminating controls on plasma cell proliferation and antibody secretion. This leads to overproduction of antibodies and immature, proliferating plasma cells spreading through the bone marrow. Consequences include kidney failure, anemia, increased risk of infection, bone lesions, and fatigue.

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    pathway multiple myeloma

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    Multiple myeloma is a cancer of plasma cells that develops due to a combination of predisposing and precipitating factors. Predisposing factors include increasing age, family history of cancer, and having monoclonal gammopathy of uncertain significance. The cancer develops as chromosomes and genes are destroyed, eliminating controls on plasma cell proliferation and antibody secretion. This leads to overproduction of antibodies and immature, proliferating plasma cells spreading through the bone marrow. Consequences include kidney failure, anemia, increased risk of infection, bone lesions, and fatigue.

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    © All Rights Reserved
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    344 views3 pages

    Pathophysiology of Multiple Myeloma

    Uploaded by

    Rifa'atul Mahmudah
    Multiple myeloma is a cancer of plasma cells that develops due to a combination of predisposing and precipitating factors. Predisposing factors include increasing age, family history of cancer, and having monoclonal gammopathy of uncertain significance. The cancer develops as chromosomes and genes are destroyed, eliminating controls on plasma cell proliferation and antibody secretion. This leads to overproduction of antibodies and immature, proliferating plasma cells spreading through the bone marrow. Consequences include kidney failure, anemia, increased risk of infection, bone lesions, and fatigue.

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    of 3

    PATHOPHYSIOLOGY OF MULTIPLE MYELOMA

    Predisposing Multiple Myeloma:

    Precipitating Factors:
    1. Stress
    2. Lifestyle

    1. Age (58 y/o) the risk of MM


    goes up with age
    2. Familial
    history
    of
    cancer
    (patients uncle)
    3. Having
    MGUS
    (Monoclonal
    Gammopathy
    of
    Uncertain
    Significance)

    Chromosomes and genes


    destroyed

    Kidney failure

    Promote gene to
    chromosomes stimulate
    antibody genes

    Eliminating controls B cell


    proliferation & antibody
    secretion

    Overproduction antibody

    Plasma cells are immature


    proliferation has suffered

    High risk infection

    Plasma tumor cells


    proliferating

    Anemia
    Hb

    Disorders of the
    musculoskeletal
    Impaire
    d
    walking

    Spread widely in the marrow


    cavity throughout the
    skeleton

    Anorexia

    Oxygen
    Hb

    Weak, dizzy,
    pale skin

    Muscle strength
    Imbalanc
    e
    Nutrition

    Impaired mobility
    Corrosion on the bone

    Risk of injury
    fracture phatologic

    Bacterial Infection of bone


    Acute Pain
    Back pain
    Numbness, muscle
    weakness in the legs

    Fatigue

    Activity
    Intolerance

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