PHARMACEUTICAL

INDUSTRY

Sheena M. Barrameda

OVERVIEW
History
Drugs
Manufacturing Process

Available Pharmaceutical Companies in

the Philippines

HISTORY
Drugs used to get rid of pain and to prevent
death
linked with the ancient belief that evil
spirits cause disease
Papyrus Ebers recorded history in the Nile
Valley that comprises drug formulas (approx. 35
ingredients)
ingredients includes botanicals, minerals and
animal products

HISTORY
Hippocrates and Galen Greeks that used
rational approach in therapy instead of mystical
Paracelsus born in 1493; may be looked upon
as the founder of chemotherapy
Liebig and students after three centuries, they
began to synthesize biologically active
compound in Germany

HISTORY
Bernard, Magendie and others developed
methods for experimental medicine in France
1881 Eli Lilly & Co was established;
groundwork for modern pharmaceutical research
begun
1970s development of gene splicing to
produce new form of living materials

DRUGS
Proof of safety of new drugs before it is
marketed
Drug categories prescription and OTC
Patent 17 years
Classified based on use, chemical structure and
on chemical reactions needed in order to
manufacture the product

DRUGS
Have great emphasis on the purity of the product

US Pharmacopeial Convention is the one that

sets standards for purity of prescription and OTC
drugs
Standards are listed in the US pharmacopeia
(USP)

Just a friendly reminder

https://www.youtube.com/watch?v=Mb7J1F
CAt8o

MANUFACTURING
PROCESS
Pharmaceutical industry have greater
variety and more complicated steps in
manufacturing process

Carboxylation and Acetylation

Salisylic Acid and Derivatives

MANUFACTURING
PROCESS
Aspirin (methyl acetyl ester) chief
derivative of salicylic acid
Carboxylation by the Schmitt modification
of the Kolbe reaction is used to
manufacture salicylic acid

MANUFACTURING
PROCESS

http://image.slidesharecdn.com/presentationq10-100323203912-phpapp02/95/presentation-q10-7-728.jpg?cb=1269377014

http://image.slidesharecdn.com/introductionandpreparationofsalicylicacid-150503015443-conversion-gate02/95/introduction-andpreparation-of-salicylic-acid-14-638.jpg?cb=1430619018

MANUFACTURING
PROCESS
https://www.youtube.com/watch?v=1CG6i
Z8Jn-M
https://www.youtube.com/watch?v=M5dQ
MvPsTEk

 Carboxylation and Acetylation

Acetaminophen (Tylenol; analgesic and
antipyretic; paracetamol)
Acetophenetidine (Phenacetin; analgesic and
antipyretic)

Condensation and Cyclization

Diazepam (Valium; tranquilizer/anti anxiety
drug

 Thiamine Hydrochloride (Vitamin B1;

antineuritic vitamin essential for bodily growth)

Alkylation
Phenolbarbital (5-ethyl-5-phenylbarbituric
acid; useful in epilepsy)
Procaine Hydrochloride
(Novocaine;anesthetic)
Cimetidine (antiulcer medication)

PHARMACEUTICAL COMPANIES IN
THE PHILIPPINES

http://finance.mapsofworld.com/company/pharmaceutical/philippines.html

PHARMACEUTICAL COMPANIES IN
THE PHILIPPINES
Pascual Laboratories
located at 817 EDSA, South Triangle,
Quezon City
http://www.pascuallab.com/index.php/about-us
http://www.pascuallab.com/index.php/products

PHARMACEUTICAL COMPANIES IN
THE PHILIPPINES
Pfizer Incorporated
located at Ayala Life FGU Center, 6811 Ayala
Ave, Makati / has branch in Canlubang, Laguna
One of the worlds premier biopharmaceutical
companies
http://www.pfizer.com/products

 Reference:
Austin. G.T. (1984). Shreeve's Chemical
Process lndustries, 5th ed. McGraw-Hill
International Edition.