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Psikiatri Mild Brain Injury
Psikiatri Mild Brain Injury
Psychiatric Association
In Review Series
Abstract
Background: Evidence regarding longer-term psychiatric, psychological, and behavioural outcomes (for example, anxiety,
mood disorders, depression, and attention disorders) following mild traumatic brain injury (mTBI) in children and adolescents
has not been previously synthesized.
Objective: To conduct a systematic review of the available evidence examining psychiatric, psychological, and behavioural
outcomes following mTBI in children and adolescents.
Materials and Methods: Nine electronic databases were systematically searched from 1980 to August 2014. Studies
selected met the following criteria: original data; study design was a randomized controlled trial, quasi-experimental design,
cohort or historical cohort study, case-control study, or cross-sectional study; exposure included mTBI (including concussion); population included children and adolescents (<19 years) at the time of mTBI, as well as a comparison group (for
example, healthy children, children with orthopaedic injuries); and included psychiatric, psychological, or behavioural outcomes (for example, anxiety, mood disorders, depression, attention disorders). Two authors independently assessed the
quality and level of evidence with the Downs and Black (DB) criteria and Oxford Centre of Evidence-Based Medicine
(OCEBM) model, respectively, for each manuscript.
Results: Of 9472 studies identified in the initial search, 30 were included and scored. Heterogeneity in methodology and
injury definition precluded meta-analyses. The median methodological quality for all 30 studies, based on the DB criteria, was
15/33 (range 6 to 19). The highest level of evidence demonstrated by all reviewed studies was level 2b based on OCEBM
criteria, with the majority (28/30 studies) classified at this level. Based on the literature included in this systematic review,
psychological and psychiatric problems in children with a history of mTBI were found to be more prevalent when mTBI is
1
2
3
4
5
Alberta Childrens Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Rady Childrens Hospital, San Diego, California, USA
Neuropsychiatric Research, Department of Psychiatry, University of California, San Diego, California, USA
Health Sciences Library, University of Calgary, Calgary, Alberta, Canada
Corresponding Author:
Carolyn A. Emery, PT, PhD University of Calgary, 2500 University Dr NW, Calgary, Alberta, T2N1N4, Canada.
Email: caemery@ucalgary.ca
260
associated with hospitalization, when assessment occurs earlier in the recovery period (that is, resolves over time), when
there are multiple previous mTBIs, in individuals with preexisting psychiatric illness, when outcomes are based on retrospective recall, and when the comparison group is noninjured healthy children (as opposed to children with injuries not
involving the head).
Conclusions: Overall, few rigorous prospective studies have examined psychological, behavioural, and psychiatric outcomes
following mTBI. In the absence of true reports of preinjury problems and when ideally comparing mild TBI to non-TBI injured
controls, there is little evidence to suggest that psychological, behavioural, and/or psychiatric problems persist beyond the
acute and subacute period following an mTBI in children and adolescents.
Abrege
Contexte : Les donnees probantes concernant les resultats psychiatriques, psychologiques et comportementaux a` long
terme (p. ex., lanxiete, les troubles de lhumeur, la depression, et les troubles de lattention) par suite dun traumatisme
cranio-cerebral benin (TCCb) chez les enfants et les adolescents nont pas ete synthetisees anterieurement.
Objectif : Mener une revue systematique des donnees probantes disponibles qui examinent les resultats psychiatriques,
psychologiques et comportementaux dun TCCb chez les enfants et les adolescents.
Materiel et methodes : Neuf bases de donnees electroniques ont ete systematiquement recherchees de 1980 au mois
daout 2014. Les etudes retenues satisfaisaient aux crite`res suivants: des donnees originales; la methode de letude etait un
essai randomise controle, une methode quasi-experimentale, une etude de cohorte ou de cohorte historique, une etude castemoin ou transversale; lexposition incluse dans le TCCb (y compris la commotion); la population comprenait des enfants et
adolescents (< 19 ans) au moment du TCCb, ainsi quun groupe de comparaison (p. ex., des enfants en sante; des enfants ayant
des blessures orthopediques); et comprenait des resultats psychiatriques, psychologiques ou comportementaux (p. ex.,
lanxiete, les troubles de lhumeur, la depression, et les troubles de lattention). Deux auteurs ont evalue independamment la
qualite et le niveau des donnees probantes a` laide des crite`res de Downs et Black (DB) et du mode`le Oxford Centre of
Evidence-Based Medicine (OCEBM), respectivement, pour chaque manuscrit.
Resultats : Sur les 9 472 etudes reperees dans la recherche initiale, 30 ont ete incluses et notees. Lheterogeneite de la
methodologie et la definition du traumatisme excluaient les meta-analyses. La qualite methodologique moyenne pour les 30
etudes, selon les crite`res DB, etait de 15/33 (ecart 6-19). Le niveau le plus eleve des donnees probantes demontre par toutes les
etudes examinees etait le niveau 2b, selon les crite`res de lOCEBM, la majorite des etudes (28/30) etant classees a` ce niveau.
Dapre`s la litterature incluse dans cette revue systematique, les proble`mes psychiatriques et psychologiques des enfants ayant des
antecedents de TCCb se sont reveles plus prevalents quand le TCCb est associe a` une hospitalisation, quand levaluation a lieu
plus tot dans la periode de retablissement (c.-a`-d., qui se resout avec le temps), quand il y a de multiples TCCb passes, chez des
personnes souffrant dune maladie psychiatrique preexistante, quand les resultats sont bases sur la memoire retrospective, et
quand le groupe de comparaison est forme denfants en sante non blesses (par opposition aux enfants blesses mais non a` la tete).
Conclusions : En general, peu detudes prospectives rigoureuses ont examine les resultats psychologiques, comportementaux et psychiatriques dun TCCb. En labsence de rapports fiables de proble`mes pre-traumatisme et en comparant
idealement des sujets ayant subi un TCCb avec des temoins nayant pas subi de TCC, il y a peu de donnees probantes qui
sugge`rent que les proble`mes psychologiques, comportementaux et/ou psychiatriques persistent au-dela` de la periode aigue et
subaigue suivant un TCCb chez les enfants et les adolescents.
Keywords
mild traumatic brain injury, concussion, psychological outcomes, psychiatric outcomes, behaviour outcomes
Background
Mild traumatic brain injuries (mTBI), including concussions, are very common in children and adolescents and
therefore pose a significant public health burden. Annually,
at least 700 000 youth ages 0 to 19 years seek hospital-based
medical care for TBI in the United States, and 80% to 90% of
these injuries are mild in severity.1 No comparable figures
are available for mTBI in Canada, but data from 8 Canadian
pediatric emergency departments indicate that 1 out of every
70 to 220 visits is for concussion.2,3 Moreover, more than
500,000 youth are registered hockey players in Canada, and
260
associated with hospitalization, when assessment occurs earlier in the recovery period (that is, resolves over time), when
there are multiple previous mTBIs, in individuals with preexisting psychiatric illness, when outcomes are based on retrospective recall, and when the comparison group is noninjured healthy children (as opposed to children with injuries not
involving the head).
Conclusions: Overall, few rigorous prospective studies have examined psychological, behavioural, and psychiatric outcomes
following mTBI. In the absence of true reports of preinjury problems and when ideally comparing mild TBI to non-TBI injured
controls, there is little evidence to suggest that psychological, behavioural, and/or psychiatric problems persist beyond the
acute and subacute period following an mTBI in children and adolescents.
Abrege
Contexte : Les donnees probantes concernant les resultats psychiatriques, psychologiques et comportementaux a` long
terme (p. ex., lanxiete, les troubles de lhumeur, la depression, et les troubles de lattention) par suite dun traumatisme
cranio-cerebral benin (TCCb) chez les enfants et les adolescents nont pas ete synthetisees anterieurement.
Objectif : Mener une revue systematique des donnees probantes disponibles qui examinent les resultats psychiatriques,
psychologiques et comportementaux dun TCCb chez les enfants et les adolescents.
Materiel et methodes : Neuf bases de donnees electroniques ont ete systematiquement recherchees de 1980 au mois
daout 2014. Les etudes retenues satisfaisaient aux crite`res suivants: des donnees originales; la methode de letude etait un
essai randomise controle, une methode quasi-experimentale, une etude de cohorte ou de cohorte historique, une etude castemoin ou transversale; lexposition incluse dans le TCCb (y compris la commotion); la population comprenait des enfants et
adolescents (< 19 ans) au moment du TCCb, ainsi quun groupe de comparaison (p. ex., des enfants en sante; des enfants ayant
des blessures orthopediques); et comprenait des resultats psychiatriques, psychologiques ou comportementaux (p. ex.,
lanxiete, les troubles de lhumeur, la depression, et les troubles de lattention). Deux auteurs ont evalue independamment la
qualite et le niveau des donnees probantes a` laide des crite`res de Downs et Black (DB) et du mode`le Oxford Centre of
Evidence-Based Medicine (OCEBM), respectivement, pour chaque manuscrit.
Resultats : Sur les 9 472 etudes reperees dans la recherche initiale, 30 ont ete incluses et notees. Lheterogeneite de la
methodologie et la definition du traumatisme excluaient les meta-analyses. La qualite methodologique moyenne pour les 30
etudes, selon les crite`res DB, etait de 15/33 (ecart 6-19). Le niveau le plus eleve des donnees probantes demontre par toutes les
etudes examinees etait le niveau 2b, selon les crite`res de lOCEBM, la majorite des etudes (28/30) etant classees a` ce niveau.
Dapre`s la litterature incluse dans cette revue systematique, les proble`mes psychiatriques et psychologiques des enfants ayant des
antecedents de TCCb se sont reveles plus prevalents quand le TCCb est associe a` une hospitalisation, quand levaluation a lieu
plus tot dans la periode de retablissement (c.-a`-d., qui se resout avec le temps), quand il y a de multiples TCCb passes, chez des
personnes souffrant dune maladie psychiatrique preexistante, quand les resultats sont bases sur la memoire retrospective, et
quand le groupe de comparaison est forme denfants en sante non blesses (par opposition aux enfants blesses mais non a` la tete).
Conclusions : En general, peu detudes prospectives rigoureuses ont examine les resultats psychologiques, comportementaux et psychiatriques dun TCCb. En labsence de rapports fiables de proble`mes pre-traumatisme et en comparant
idealement des sujets ayant subi un TCCb avec des temoins nayant pas subi de TCC, il y a peu de donnees probantes qui
sugge`rent que les proble`mes psychologiques, comportementaux et/ou psychiatriques persistent au-dela` de la periode aigue et
subaigue suivant un TCCb chez les enfants et les adolescents.
Keywords
mild traumatic brain injury, concussion, psychological outcomes, psychiatric outcomes, behaviour outcomes
Background
Mild traumatic brain injuries (mTBI), including concussions, are very common in children and adolescents and
therefore pose a significant public health burden. Annually,
at least 700 000 youth ages 0 to 19 years seek hospital-based
medical care for TBI in the United States, and 80% to 90% of
these injuries are mild in severity.1 No comparable figures
are available for mTBI in Canada, but data from 8 Canadian
pediatric emergency departments indicate that 1 out of every
70 to 220 visits is for concussion.2,3 Moreover, more than
500,000 youth are registered hockey players in Canada, and
261
Methods
The review was conducted according to the PRISMA
guidelines.39
Study Selection
We used the following inclusion criteria: 1) The study design
included randomized controlled trial, quasi-experimental
design, cohort or historical cohort study, case-control study,
or cross-sectional study. Systematic reviews or meta-analyses
were used to identify additional relevant studies. 2) Children/
adolescents were <19 years of age at the time they sustained
the mTBI. 3) Brain injury severity studied was restricted to
mTBI (although varying definitions were accepted, including
traditional definitions such as a postresuscitation Glasgow
262
Table 1. Evaluation of Psychiatric, Psychological, and Behavioural Outcomes Following Mild Traumatic Brain Injury (mTBI) in Children and
Adolescents: Search Results of a Systematic Review.
MEDLINE EMBASE Cochrane PsycINFO PubMed
CINAHL
ERIC
SPORTDiscus
WoS
mTBI
Psychiatric, etc.
Pediatric
mTBI and psychiatric and
pediatric
Limit to humans
Limit to English
Limit to 1990
Limit to not MEDLINE
Total citations
After duplicates removed
After screening
After eligibility
Articles included
14 134
9472
105
58
30
3404
2 862
2314
6488
5 468
4919
240
3081
4492
63
37 042
769 053
690
690 492
3878
67 063
450 572
691 292
5250
5758
121 386
92 904
364
6868
63 442
137 093
110
101 431
1 173 453
1 506 614
1 827
63
1912
1695
1205
2787
5187 (1990)
5177 (English)
2778 (humans)
640 (not
MEDLINE)
341
108
107
1 777
1 758
Data Synthesis
Extracted data and quality and level of evidence were summarized for each study.
Results
Identification of Studies
An overview of the study identification process is provided
in Figure 1. A detailed breakdown of the search process is
summarized in Table 1. The initial search yielded 14 134
manuscripts; 4663 duplicates were removed, leaving 9472
potentially relevant articles. Following title and abstract
review by 2 authors (A.V.-R, V.G.) to identify potential
relevant records, 105 abstracts were selected and reviewed
by 1 additional pair of authors (2/6 authors) for relevance
and inclusion, resulting in a total of 58 full manuscripts.
These 58 manuscripts were divided among 3 pairs of
reviewers (6 reviewers) and further narrowed to 30 full
manuscripts that were included in the systematic review
based on inclusion/exclusion criteria.24,27,31,32,41-66
263
Idencaon
mTBI SR
search performed 2014.08.15
MEDLINE 2314
EMBASE 4919
Cochrane 63
PsycINFO 1205
PubMed 2787
CINAHL 640
ERIC 341
SPORTDiscus 107
Web of Science 1758
TOTAL - 14134
Eligibility
Screening
Records screened
(n = 105)
Records excluded
(n = 9367)
Inc luded
Studies included in
qualitave synthesis
(n = 30)
Studies included in
quantave synthesis
(meta-analysis)
(n = n/a)
Study Characteristics
Effect Estimates
Descriptions of effect estimates are presented in Table S1.
264
Synthesis of Results
The most commonly investigated behavioural/psychological/psychiatric outcomes that were included in multiple
studies were attention problems, depression and mood
disorders, anxiety, oppositional defiant disorder (ODD)/
disruptive behaviours, and posttraumatic stress disorder
(PTSD). In addition, autism/pervasive developmental disorder, schizophrenia, and substance abuse were evaluated
in 1 study each.
Attention Problems and Hyperactivity. Attention problems and
hyperactivity are the most commonly studied psychological/
psychiatric/behavioural outcomes of mTBI in youth. The
findings are fairly consistent, with higher rates of inattentive/hyperactive symptoms reported 1) in those who are hospitalized versus not hospitalized for mTBI and 2) when
comparing youth with mTBI to healthy (noninjured)
controls.
Several studies reported that children and adolescents
who are hospitalized for mTBI display more symptoms of
inattention and hyperactivity than those who are not hospitalized or healthy controls.44,46-48 Hawley et al44 reported a
relative risk of 6.34 for attention problems in youth who
were hospitalized for a mTBI, but the comparison group was
composed of healthy controls, and problems were reported
based on parents retrospective recall more than 2 years after
the injury.
The comparison group used for examining psychological/
behavioural symptoms in children with mTBI is key for
many studies, especially those focused on attention/hyperactivity. When youth with mTBI are compared with healthy
noninjured controls, secondary attention-deficit hyperactivity disorder (ADHD) is found in a higher proportion of the
children with mTBI (for example, Schachar et al50 reported
that 36% of mTBI and 12% of noninjured controls have
secondary ADHD). Youth who sustain any type of injury
are more likely to display attention problems; thus, using a
noninjured comparison group is likely to overestimate group
265
Discussion
MTBI affects a large number of children and adolescents
each year in Canada, through both sport-related and non
sport-related mechanisms. Although the vast majority of
children with mTBI recover relatively quickly and with few
sequelae,16,17 a small proportion displays persistent problems, often leading to a delayed return to school, a need for
academic accommodations, a delayed return to sport, and an
increased level of health care services. Although somatic
symptoms (for example, headaches, dizziness) are often the
focus following mTBI and a key marker of recovery,17,67
psychological/psychiatric recovery is also an important
aspect of postinjury outcome and recovery for children and
adolescents. Based on our systematic review, the evidence
for increased psychological, behavioural, and psychiatric
problems following a mTBI is mixed, most often based on
symptom ratings (not actual diagnosis) and founded on a
small number of studies characterized by multiple methodological limitations. Overall, some evidence supports an
increased prevalence of psychological, behavioural, and psychiatric problems (that is, symptoms) when 1) mTBI is associated with hospitalization,48 2) the injury occurs early in life
(<6 years old),48,58,63 3) outcomes are assessed earlier after
injury (that is, suggesting resolution over time),27 4) there
are multiple previous mTBIs,63 5) individuals have preexisting psychiatric illness, 56,62 6) outcomes are based on
266
retrospective recall,44 and 7) the comparison group is noninjured healthy children rather than children with nonhead
injuries.50
A recent systematic review of psychosocial outcomes in
children and adolescents with mTBI reached similar conclusions. Keightley et al38 reported an increased likelihood of
psychological or psychiatric problems in the short term following a mTBI in youth (that is, specifically increased risk
of mood disturbance and hyperactivity; no increased risk of
PTSD) but did not find evidence for long-term psychological
or psychiatric problems. Keightley et als systematic review
contained some of the same publications as this one but was
more limited in scope, including only 6 studies.38 The current systematic review was based on a wider time frame for
literature searching and a broader perspective on outcome
but yielded similar conclusions about early psychosocial
problems that resolve with time. Previous reviews of psychosocial outcomes have suggested more long-term difficulties after pediatric TBI but have based their conclusions on
studies that include children with more severe TBI, rather
than limiting their review to studies specifically of
mTBI.36,37
In many studies of psychological, behavioural, and psychiatric outcomes, comparison groups were composed of
healthy noninjured youth. Like all research on mTBI, the
comparison group is key to properly interpreting results.
Studies that compare children with mTBI to healthy controls
are more likely to find significantly elevated rates of psychological and psychiatric problems than studies that compare children with mTBI to children with orthopaedic
injuries. The use of a healthy control group fails to control
for the nonspecific effects of sustaining an injury or the risk
of sustaining an injury based on preexisting risk factors. In
fact, comparisons that are significant when based on a
healthy control group50 may disappear when comparisons
are made to controls with orthopaedic injuries (for example,
Max et al45). The use of children with nonhead injuries as a
comparison group represents a more appropriate and rigorous methodology for understanding outcomes following
pediatric mTBI.
Another key methodological distinction should be drawn
between significantly higher symptom ratings after mTBI
versus significantly higher rates of psychological/psychiatric
diagnoses. The former has much more support at present
than the latter. The current systematic review highlighted
the use of both methods for studying psychological/behavioural/psychiatric outcomes. Both are worthy methods for
studying outcome, but results can differ across the 2
approaches, and the interpretation of findings varies accordingly. Significantly higher symptom ratings do not necessarily translate into clinically elevated levels of problems or
formal diagnosis. For example, significantly higher levels of
symptoms of withdrawal were reported for children who
sustained mTBI early in life58; however, the mean scores
were still well within the normal range. Similar findings
were reported for anxiety symptoms in young children with
Limitations
Meta-analyses were not possible because of inconsistent
methodology and heterogeneity of outcome measures and
research design methodologies. The inclusion of Englishonly studies may also have led to selection bias. Inadequate
reporting and control for potential confounders (for example,
multiple concussion history, age, sex) may have led to bias in
study results presented. In some studies, the inability to consider potential confounding was related to smaller sample
sizes. Recruitment of study participants was not random in
most studies, and selection bias may be associated with differences in participants selected for the study and those not
selected (for example, presenting to a large emergency
department vs. a primary care setting). Significant losses to
follow-up also increased the likelihood of selection bias in
many studies. Reliance on self-report measures and questionable validity of other measures also introduced measurement bias in many studies. Given significant concerns with
internal validity, generalizability is also questionable in this
body of literature.
Recommendations
More research is needed to tease out the complex interplay of
preexisting and new-onset psychological/behavioural/psychiatric problems and mTBI. These studies should employ
suitable control groups including children with non-TBI
injuries. Further, distinctions should be made between
Conclusions
Although psychological, behavioural, and psychiatric problems can occur early in the recovery phase following mTBI,
these resolve in most cases. Children at risk for longer-term
problems are those with multiple previous mTBI or preexisting psychiatric illness.
Funding
The author(s) disclosed receipt of the following financial support
for the research, authorship, and/or publication of this article:
Carolyn A. Emery, PT, PhD, holds a Chair in Pediatric Rehabilitation supported by the Alberta Childrens Hospital Foundation.
Keith Owen Yeates, PhD, holds a Chair in Paediatric Brain Injury
supported by the Alberta Childrens Hospital Foundation. These
sponsors had no involvement with respect to design, collection or
data analyses, interpretation, writing or submission.
Supplemental Material
The supplemental table cited in this article is available online at
http://cpa.sagepub.com/supplemental.
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