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GNRH Agonists and Antagonists in Cyclophosphamide Induced Ovarian Damage Friend or Foe 2013 Fertility and Sterility
GNRH Agonists and Antagonists in Cyclophosphamide Induced Ovarian Damage Friend or Foe 2013 Fertility and Sterility
(OR), 95% confidence interval (CI): 1.7, 1.3-2.1), being younger at diagnosis
versus being aged 30-35 (aged 20-24: 1.5, 1.0-2.1; aged 25-29: 1.1, 0.8-1.4),
being African American versus being white (1.2, 0.9-1.6), and not being
treated with chemotherapy or radiation (3.1, 2.4-4.1). These ORs and 95%
CIs were similar in a model restricted to women treated with chemotherapy
or radiation. Among women who discussed fertility, 6% of those with a child
and 19% of those without were referred to a specialist.
CONCLUSION: Over half of reproductive-age women with cancer do not
discuss fertility with a doctor before treatment, and even fewer are referred to
a specialist. Some women, especially those aged 20-24, may not be getting
the information they need to make informed decisions about fertility preservation prior to cancer treatment.
Supported by: NICHD 5R01HD066059.
P-70 Tuesday, October 15, 2013
GnRH AGONISTS AND ANTAGONISTS IN CYCLOPHOSPHAMIDE-INDUCED OVARIAN DAMAGE: FRIEND OR FOE? H. A.
Parlakgumus,a E. B. Kilicdag,a F. Bolat,b B. Haydardedeoglu,a
A. Parlakgumus.c aObstetrics and Gynecology, Baskent University, Adana,
Turkey; bPathology, Baskent University, Adana, Turkey; cGeneral Surgery,
Baskent University, Adana, Turkey.
OBJECTIVE: To determine whether GnRH agonist(GnRHa) or antagonist(GnRHant) administration protects the ovarian follicles from cyclophosphamide(Cyc) induced damage and whether the processes were mediated by
AMH.
DESIGN: Experimental study.
MATERIALS AND METHODS: The control group had intraperitoneal(ip) saline injection. The GnRHa group had a single subcutaneous(sc) leuprolide acetate(LA, 1 mg/kg) 28 days prior to a ip saline. The GnRHant
group received a single ip cetrorelix acetate(CA, 0.1 mg/kg) 1 h prior to ip
saline. The Cyc group had an ip Cyc(75 mg/kg) at day 28. The GnRHa +
Cyc group had sc LA(1 mg/kg) 28 days prior to ip Cyc(75 mg/kg). The
GnRHant + Cyc group had an ip CA(0.1 mg/kg) 1 h prior to an ip Cyc(75
mg/kg). After oophorectomy on day 35,primordial follicles(PMFs) were
counted and AMH expression was assessed by H score. Kruscal Wallis
test, c2 test or Fisher Exact test were used in statistical analysis. p<0.05
was considered statistically significant.
RESULTS: The Cyc(p0.003) and GnRHant(p0.003) groups had fewer
PMFs than the control group. GnRHa+Cyc, GnRHant+Cyc and Cyc groups
had similar numbers of PMFs. The H score was lower in the GnRHa(p
<0.001), GnRHant(p0.003), and Cyc(p0.002) groups than in controls.
H scores of GnRHa+Cyc(p0.01) and GnRHant +Cyc(p0.002) groups
were lower than Cyc group.
2.92.5a
11.4b
S168
ASRM Abstracts