Atropine_stability

http://www.bvsde.paho.org/bvstox/fulltext/atropine.pdf
Atropine
Atropine sulfate
3.6 pH
A saturated solution of atropine
A 2% solution in water has a pH of 4.5 to 6.2
in water is alkaline (Parfitt,1999).
(Parfitt,1999).
3.7 Stability
Atropine should be protected Atropine sulphate is slowly affected by light (McEvoy,
in light
from light, and stored in airtight 2002). It should be protected from light and stored
containers (Parfitt, 1999).
in airtight containers (Parfitt, 1999).
3.8 Reactivity When heated to decomposition, Atropine sulphate effloresces when exposed to dry
toxic fumes of oxides of nitrogen air (McEvoy, 2002). When heated to decomposition,
are emitted (Sax , Lewis, 1992). toxic fumes of oxides of nitrogen and sulphide are
emitted (Sax, Lewis 1992).
http://www.pharmacopeia.cn/v29240/usp29nf24s0_m6410.html
Atropine Sulfate injection
pH 3.0-6.5

USP29

https://www.medicines.org.uk/emc/medicine/20905
Atropine Sulfate Injection 600mcg in 1ml
6.1 List of excipients
Water for Injections Ph. Eur.
Sulfuric acid 1N (for pH adjustment)
6.2 Incompatibilities
Atropine sulfate injection is reported to be physically incompatible with bromides, iodides,
alkalis, noradrenaline bitartrate, metaraminol bitartrate and sodium bicarbonate. A haze or
precipitate may form within 15 minutes when atropine sulfate is mixed with methohexital
sodium solutions.
6.3 Shelf life
36 months.
6.4 Special precautions for storage
Protect from light. Store at less than 25 C.

6.5 Nature and contents of container

Type I clear glass ampoule, 1ml. Packed in cardboard cartons to contain 10 ampoules x 1ml.
6.6 Special precautions for disposal and other handling
Use as directed by the physician.
https://www.drugs.com/monograph/atropine-sulfate.html
Injection
25C (may be exposed to 1530C).
Protect from freezing and light.