-white bond

-opaque, no moisture resistance

PART 1: PREPARATIONS
Preparation 1: Anhydrous Thyroxine Na
Category:
Powder - drug or chemical in dry form which can be taken
internally (nose, throat, tooth) or externally (skin)

-glassine
- waxed, transparent w/ moisture
resistance
-waxed
-transparent with water proof properties

Production Method:
1. Comminution/ Particle Size -reduction of particle
size
Large Scale - mill
Extemporaneous
-Trituration - reducing by rubbing the
particles by mortar & pestle.
-Pulverization by intervention - state
of condition of solid with the aid of anoher
example: camphor + alcohol
iodine + ether
- Levigation - formulation of paste by
a levigating agent (example: glycerin)

2. . Paper boxes/ Powder Envelopes

Special Problems:
Volatile Substance -sealed plastic envelope
-double wrapped with bond paper
Eutectic Mixture -add diluents (starch, lactose)
-ASA, camphor, menthol
Hygroscopic-absorb/ adsorb moisture
- ZnCl, NaCl
Deliquescent -absorbs moisture & liquid
- CuSO4
*Powder chartulae
*Description- properly folded
*Uses- thyroxine
Formulation

2. Blending/ Mixing
extemporaneous
-spatulation
-trituration
-sifting
-tumbling
-geometric dilution (potent drug)
*geometric dilution 1g diluet ==> 1 g potent
3. Divided Powder
- weighing
-block & divide
4. Packaging Material
1. Powder Paper Type
-vegetable parchment
-thin, semi-opaque, moistureresistant

Ingredients

OriginalAmount

ComputedAmount

Eltroxin
Lactose

100 mcg
200 mg

25 mcg
50 mg

Procedure:
1. triturate lactose
2. pulverized tablet
3. Mix together
4. Place in pill tile, form a block then divide into 4potions
5. Wrap each individually in a glassine paper & place in paper
envelope
Label: white
Container: papertab (8 x13)
Envelope: (17 x 12..5)