ISM Presentation Outline Assignment for Mid Term Presentation

Slide 1: Hyperlipidemia Treatments (Statin vs. PCSK9)

Slide 2: Hyperlipidemia Treatments
Presented by: Abhishek Amin
Mentor: Rakesh Shah, MD
Bay Area Heart
Cardiology
Independent Study Mentorship Fall 2016
ISM Teacher: Mrs.Click
Slide 3: What is ISM?
ISM is an Independent Study Mentorship for High School Students to experience real
world jobs
Slide 4: What is Hyperlipidemia?
Hyperlipidemia is caused by a group of genetic diseases that lead to vast amounts of
lipids inside of ones body
Slide 5: Why I chose Hyperlipidemia
Hyperlipidemia interests me because my family has a history of Cholesterol problems
Slide 6: Treatment Options for Hyperlipidemia
There are two treatment options which would be Statin and PCSK9, also there is the
possible solution of just eating better
Slide 7: Statin Treatment Pros
Statin can prevent more blockage from being created in your blood vessels and prevent
future heart attacks.

Slide 8: Statin Treatment Cons

Statin treatment has been the go to treatment to lower cholesterol but it doesnt reduce it
enough in 1/5 of people
Additionally, some people are unable to take Statin because of its side affects, muscle
pain, liver damage, or leading to diabetes.
Slide 9: How Statin treatment works
They block a resource in your body which is used to create cholesterol.
Statins also absorb cholesterol deposited in your artery walls causing plaque and
disrupting flow.
Slide 10: PCSK9 treatment pros
PCSK9 inhibitors are antibodies that are monoclonal.
Convertase subtilisin kexin 9 helps create healthier arteries, fewer heart attacks and
strokes, as well as reduces cholesterol based diseases.
Slide 11: PCSK9 treatment cons
However, this treatment is very expensive, a one year treatment could be upwards of
$12,000.
These drugs are still experimental since the trials havent been published yet.
Slide 12: How PCSK9 treatment works
They target a specific protein inside of the liver and render it useless by blocking the
creation of it
It knocks out the proprotein called convertase subtilisin kexin 9 which significantly
reduces the amount of low density lipoproteins in the bloodstream of the body

Slide 13: Demonstration video of how the treatments work

I have determined the website I am going to use to create the demonstration and have
begun working on the video

Slide 14: To sum it all up

This slide is still in progress as I have not conducted enough research to make a
conclusive statement
Slide 15: Thank You Slide
I would like to thank Dr. Rakesh Shah
I would like to thank Mrs. Nancy Badillo
I would like to thank all of the office staff
I would like to thank Mrs. Click
I would like to thank my evaluators
Lastly I would like to thank my mom for giving birth to me
Slide 16: Work Cited
Curfman, Gregory, MD. "PCSK9 Inhibitors: A Major Advance in Cholesterol-lowering Drug
Therapy." Web log post. Harvard Health Publication. Harvard University, 15 Apr. 2015.
Web. 1 Oct. 2016.
Mayo Clinic Staff. "Statins: Are These Cholesterol-lowering Drugs Right for You?" Mayo Clinic.
Mayo Clinic, 8 Apr. 2015. Web. 1 Oct. 2016.
<mayoclinic.org>

Randall, Otelio S., Deborah S. Romaine, and Nathan M. Segerson. "Hyperlipidemia." The
Encyclopedia of the Heart and Heart Disease, Second Edition. N.p.: Facts On File, 2010.
Health Reference Center. Web. 1 Oct. 2016.
Wells, Ken R., and Taryn Terry, DC, MSACN, BA. "Hyperlipoproteinemia." The Gale
Encyclopedia of Genetic Disorders. Ed. Tracie Moy and Laura Avery. 4th ed. Vol. 2.

Farmington Hills, MI: Gale, 2016. 958-961. Science in Context. Web. 1 Oct. 2016.