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Action Potential Jens Ellrich
Action Potential Jens Ellrich
Jens Ellrich
Action Potential
Understand the basics of
electrochemical gradients in neurons.
Outline the ionic basis of
the resting membrane potential.
Outline the ionic basis of the action potential
with particular reference to potassium and sodium
ion channels.
Jens Ellrich
Electrical potential
Electrical potential is the potential energy per unit of charge associated with a
static electrical field measured in volts (U=W/Q).
Potential difference is a quantity related to the amount of energy that is
required to move an object from one place to another against various types of
forces.
Storage lake, Dam
Waterfall
Lake
+ potential difference
no flow
+ potential difference
flow
no potential difference
no flow
Jens Ellrich
Jens Ellrich
Jens Ellrich
Driving forces
Jens Ellrich
Species of ion
Intracellular
Concentration
(mmol/l)
Extracelluar
Concentration
(mmol/l)
K+
120
Na+
14
140
Cl-
120
Equilibrium
Potential
(mV)
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Species of ion
Intracellular
Concentration
(mmol/l)
Extracelluar
Concentration
(mmol/l)
Equilibrium
Potential
(mV)
K+
120
-89
Na+
14
140
60
Cl-
120
-89
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Na+-K+ pump
active
electrogenic
continuous
emphasis on K+ leakage
100 times as permeable to K+
Jens Ellrich
Na+-K+ pump
binding of Na+
phosphorylation
conformational change
release of Na+
binding of K+
triggering dephosphorylation
return to
original conformation
release of K+
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Jens Ellrich
Refractory periods
Jens Ellrich
Refractory periods
Jens Ellrich
Refractory periods
Jens Ellrich
Jens Ellrich