Paper I

1. Discuss 20x2=40
A. Measures of Clinical Pharmacokinetics
B. Animal models for screening new compounds for their potential utility
in treating peptic ulcer

2. Write briefly on 10x6=60

A. Sampling methods in cohort studies
B. Meta analysis
C. Measures of central tendency in statistics
D. Genetic variations in receptors and enzymes modifying drug action
E. Concept of Rational Drug use
F. Nanoparticle - based therapeutics

Paper II

1. Discuss 20x2=40
A. Drug management of acute attack of myocardial infarction and its possible
Consequences with rationale for use of each drug
B. Pharmacology of drugs acting on proximal renal tubules

2. Write briefly on 10x6=60

A. Therapeutic and toxicological importance of drugs modulating vagal action
on the heart
B. Therapeutic relevance of other mechanisms of action of Beta blockers.
C. Endothelin receptor antagonists
D. Recent advances in the treatment of glaucoma
E. Potential therapeutic applications of statins
F. Angiotensin receptor antagonists
Paper III

1A. Discuss the management of an acute attack of migraine explaining the

pharmacological basis for use of each drug. Add a note on the prophylactic
treatment of migraine 20

1B. Discuss the therapeutic applications and limitations of drugs modifying

adrenergic actions in brain. 20

1. Write briefly on 10x6=60

A. Oral anticoagulants
B. GABA modulators
C. Treatment of ethanol dependence. Add a note on methanol poisoning
D. Novel therapeutic targets in enteric nervous system disorders
E. Second generation antihistamines
F. Plasma expanders

Paper IV

1A. Discuss mechanism of action, advantages and limitations of drugs affecting

bone mineral density in postmenopausal women 20

1B. Pharmacology of Natural products in treatment of neoplasms 20

2. Write briefly on
A. Mechanism of action of methylprednisolone as immunosuppressant
B. Insulin analogs
C. HIV vaccines
D. Iodides in clinical practice
E. Treatment of MDR tuberculosis
F. Drugs for Staphylococcal infections