INTRODUCTION

The hydrolysis of the ester methyl acetate in aqueous solution follows the
stoichiometry:

The reaction is catalyzed by hydrogen ions and follows the second order
rate law:

Because the hydrogen ion acts as a catalyst the reaction behaves as a first order
reaction with the rate law

This reaction can be followed analytically by sampling the

reaction mixture and titrating the samples with sodium
hydroxide for the total acid concentration. The acid in the
reaction mixture consists of H+ from the catalyst (HCl) and the
acetic acid, CH3CO2H, produced by the reaction. The total acid
concentration and the HCl concentration allows one to calculate
the CH3CO2H concentration. One experiment was carried out
to determine values for both the apparent first order rate
constant k' and the second order rate constant k.
The experiment was performed according to the instructions for Experiment 0,
A Kinetic Study of the Acid-Catalyzed Hydrolysis of Methyl Acetate
(Chemistry 2710 Laboratory Manual, Spring 2006). The initial concentrations
of hydrochloric acid and of methyl acetate in the reaction mixture were both
0.100 M and the reaction mixture was kept at 25C in a thermostatic bath. At
approximately 10-minute intervals, 25.00 mL aliquots of the reaction mixture
were removed and poured onto ice (to slow the reaction) and titrated as quickly

as possible with 0.100 M sodium hydroxide solution using phenolphthalein

indicator

Procedure:
1. prepare [100] ml of [0.1] N from HCl
2. prepare [100] ml of [0.1] N from NaOH
3. put [100] ml from [0.1] N of HCl into the flask
4. by pipette Move 5 ml of the ester to the flask
containing of [100] ml from [0.1] N HCl.
5. Shaking and record time from the beginning Shaking as a time of the
beginning reaction
6. After [10] minutes of shaking pull [10] ml from the reaction solution
and add [20] of cold ice water to stop the reaction. Rapidly titrate
solution with [0.1] N from NaOH and used ph.ph as indicater[until
formation pink color] volume of NaOH=a
7. When the hydrolysis of the ester full or released the largest amount
of acetic acid from the interaction needs to be, for example, a long-time
4-hour alternative way. put [10] ml of ester solution in a small beaker
containing a few water condensers. Or boiling in a water bath for one
hour to we get the decomposition of aqueous ester fully and titrate with
[0.1] N from NaOH and used ph.ph as indicator [until formation pink
color] volume of NaOH=x
Every titration process, the amount of the base depleting = x ml and It
is equivalent to the amount of HCl in [10] ml + The amount of acetic
acid is released from the reaction
a = It is equivalent amount HCl in [10] ml + The amount of acetic acid
is released from the fully hydrolysis of ester
a-x= Equivalent to the amount of non-reactive ester after a time of t
Place the table as follows

Calculate the half-life t1/2.

T min

X ml

a-X ml

a/(a-X)

Ln a/(a-X)

Draw ln a/ a-x versus t and extracted the order reaction and find rate
constant k