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    Biofar Latihan 2

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    dittarestiany
    This document contains data from a pharmacokinetic study comparing an oral capsule formulation to an intravenous formulation. It includes timepoint data for concentration in plasma, area under the curve calculations, and comparisons of absorption between the two formulations. Graphs are presented showing linear regression lines for the log concentration over time data. Summary statistics are also reported for the total area under the curve values across 8 subjects.

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    Biofar Latihan 2

    Uploaded by

    dittarestiany
    10 views6 pages
    This document contains data from a pharmacokinetic study comparing an oral capsule formulation to an intravenous formulation. It includes timepoint data for concentration in plasma, area under the curve calculations, and comparisons of absorption between the two formulations. Graphs are presented showing linear regression lines for the log concentration over time data. Summary statistics are also reported for the total area under the curve values across 8 subjects.

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    latihan

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    biofar latihan 2

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    This document contains data from a pharmacokinetic study comparing an oral capsule formulation to an intravenous formulation. It includes timepoint data for concentration in plasma, area under the curve calculations, and comparisons of absorption between the two formulations. Graphs are presented showing linear regression lines for the log concentration over time data. Summary statistics are also reported for the total area under the curve values across 8 subjects.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    10 views6 pages

    Biofar Latihan 2

    Uploaded by

    dittarestiany
    This document contains data from a pharmacokinetic study comparing an oral capsule formulation to an intravenous formulation. It includes timepoint data for concentration in plasma, area under the curve calculations, and comparisons of absorption between the two formulations. Graphs are presented showing linear regression lines for the log concentration over time data. Summary statistics are also reported for the total area under the curve values across 8 subjects.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    of 6

    waktu

    oral
    0
    0.5
    1
    1.5
    2
    3
    4
    6
    8

    AUC (0-8)
    Slope 3 titik terakhir (dalam bentuk ln)
    AUC (8-~)
    AUC total

    F absolut = AUC SO/AUC IV*D(IV)/D (SO)*100%

    kadar
    iv
    0
    2.75
    6.24
    8.5
    9.81
    7.43
    5.6
    3.19
    1.91

    6.136
    5.31
    4.62
    4.02
    3.5
    2.65
    2.01
    1.16
    0.66

    AUC SO
    0.6875
    2.2475
    3.6850
    4.5775
    8.6200
    6.5150
    8.7900
    5.1000
    -7.6400
    40.2225
    -0.268916
    7.102594

    Ln SO
    Err:502
    1.0116
    1.8310
    2.1401
    2.2834
    2.0055
    1.7228
    1.1600
    0.6471

    AUC IV
    2.8615
    2.4825
    2.1600
    1.8800
    3.0750
    2.3300
    3.1700
    1.8200
    -2.6400
    19.7790
    -0.278413
    2.370583

    oral

    Ln IV
    1.8142
    1.6696
    1.5304
    1.3913
    1.2528
    0.9746
    0.6981
    0.1484
    -0.4155

    12
    10
    8
    6
    4
    2
    0
    0

    intravena

    8.000
    6.000
    4.000

    47.33

    22.15

    2.000
    0.000

    85.46437

    Ln Intra Vena
    1.0000
    Axis Title

    f(x) = - 0.2784125415x Colu


    +1
    Line
    R = 0.9999456498

    0.5000
    0.0000
    -0.5000

    Axis Title

    oral

    Column B

    intravena

    Column C

    Ln Intra Vena

    Ln Oral
    2.0000

    G
    f(x) = - 0.2784125415x Column
    + 1.8141550101
    Linear (Column G)
    R = 0.9999456498
    4

    Axis Title

    Axis Title

    f(x) = - 0.2689158389x +
    2.7901252857
    Column
    E
    R = 0.9992852363
    Linear (Column E)

    1.0000
    0.0000
    3

    Axis Title

    389x +
    2.7901252857
    Column
    E
    3
    Linear (Column E)

    No sampel

    AUC total kapsul A


    1
    2
    3
    4
    5
    6
    7
    8

    Rata-rata F
    Standar deviasi (SF)
    Standar deviasi rataan (Sf)
    t (dk=7)
    CLI (+)
    CLI (-)

    AUC Total kapsul STD


    15
    22
    18
    18
    16
    17
    18
    17

    15.8
    19
    19.3
    18.4
    17.2
    16.5
    17.9
    17.5

    F
    94.9367
    115.7895
    93.2642
    97.8261
    93.0233
    103.0303
    100.5587
    97.1429
    99.4464
    7.4539
    2.6353
    1.8950
    2.365
    3.499
    104.4404 105.679 108.6675
    94.4525 93.21386 90.22538

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