Child Neuropsychology: A Journal on Normal and Abnormal Development in Childhood and

Adolescence

http://www.tandfonline.com/doi/full/10.1080/09297049.2015.1081678
Olfactory function is a well-known early biomarker for neurodegeneration and neural functioning in the
adult population, being supported by a number of brain structures that could be dysfunctioning in
neurodegenerative processes. Evidence has suggested that atypical sensory and, particularly,
olfactory processing is present in several neurodevelopmental conditions, including autism spectrum
disorders (ASDs). In this paper, we present data obtained by a systematic literature review, conducted
according to PRISMA guidelines, regarding the possible association between olfaction and ASDs, and
analyze them critically in order to evaluate the occurrence of olfactory impairment in ASDs, as well as
the possible usefulness of olfactory evaluation in such conditions. The results obtained in this analysis
suggested a possible involvement of olfactory impairment in ASDs, underlining the importance of
olfactory evaluation in the clinical assessment of ASDs. This assessment could be potentially included
as a complementary evaluation in the diagnostic protocol of the condition. Methods for study selection
and inclusion criteria were specified in advance and documented in PROSPERO protocol
#CRD42014013939.

Fungsi penciuman adalah biomarker awal terkenal untuk neurodegeneration dan

saraf berfungsi dalam populasi orang dewasa, yang didukung oleh sejumlah
struktur otak yang bisa dysfunctioning dalam proses neurodegeneratif. Bukti
telah menyarankan bahwa atipikal sensorik dan, terutama, pengolahan
penciuman hadir dalam beberapa kondisi perkembangan saraf, termasuk
gangguan spektrum autisme (ASD). Dalam tulisan ini, kami menyajikan data
yang diperoleh oleh tinjauan literatur sistematis, dilakukan sesuai dengan
pedoman PRISMA, mengenai kemungkinan hubungan antara penciuman dan
ASD, dan menganalisis mereka kritis untuk mengevaluasi terjadinya gangguan
penciuman di ASD, serta mungkin kegunaan evaluasi penciuman dalam kondisi
seperti itu. Hasil yang diperoleh dalam analisis ini menyarankan keterlibatan
kemungkinan gangguan penciuman di ASD, menggarisbawahi pentingnya
evaluasi penciuman dalam penilaian klinis ASD. Penilaian ini bisa berpotensi
dimasukkan sebagai evaluasi pelengkap dalam protokol diagnostik kondisi.
Metode untuk seleksi dan inklusi kriteria penelitian yang ditentukan di muka dan
didokumentasikan dalam Prospero protokol # CRD42014013939.