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    Perhitungan Obat Miniaspi (B)

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    Lee Auliea
    This document reports on the results of an experiment to determine the dissolution rate of Drug B (Miniasin) tablets. It provides the absorbance readings over time for two groups of Drug B tablets. It then uses the readings to calculate the drug concentration at various time points, the cumulative amount of drug dissolved over time, and performs linear regression to determine the dissolution rate constant. The average log time for the two tablet groups to dissolve 50% of the drug was calculated to be 8.141 minutes.

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    Perhitungan Obat Miniaspi (B)

    Uploaded by

    Lee Auliea
    29 views5 pages
    This document reports on the results of an experiment to determine the dissolution rate of Drug B (Miniasin) tablets. It provides the absorbance readings over time for two groups of Drug B tablets. It then uses the readings to calculate the drug concentration at various time points, the cumulative amount of drug dissolved over time, and performs linear regression to determine the dissolution rate constant. The average log time for the two tablet groups to dissolve 50% of the drug was calculated to be 8.141 minutes.

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    ME

    Original Title

    26773_perhitungan Obat Miniaspi (b)

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    This document reports on the results of an experiment to determine the dissolution rate of Drug B (Miniasin) tablets. It provides the absorbance readings over time for two groups of Drug B tablets. It then uses the readings to calculate the drug concentration at various time points, the cumulative amount of drug dissolved over time, and performs linear regression to determine the dissolution rate constant. The average log time for the two tablet groups to dissolve 50% of the drug was calculated to be 8.141 minutes.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as docx, pdf, or txt
    29 views5 pages

    Perhitungan Obat Miniaspi (B)

    Uploaded by

    Lee Auliea
    This document reports on the results of an experiment to determine the dissolution rate of Drug B (Miniasin) tablets. It provides the absorbance readings over time for two groups of Drug B tablets. It then uses the readings to calculate the drug concentration at various time points, the cumulative amount of drug dissolved over time, and performs linear regression to determine the dissolution rate constant. The average log time for the two tablet groups to dissolve 50% of the drug was calculated to be 8.141 minutes.

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    of 5

    KELOMPOK 1 OBAT B (MINIASIN)

    T
    (menit
    )
    15
    30
    45
    60

    Absorbansi Uji

    1,142
    0,800
    0,547
    0,617

    Absorbansi Kontrol

    0,473
    0,402
    0,384
    0,219

    As-Ak
    15

    = 1,142 0,473
    = 0,669

    30

    = 0,8 0,402
    = 0,398

    45

    = 0,547 0,384
    = 0,163

    60

    = 0,617 0,219
    = 0,398

    C (mg%)
    15

    = bx + a (reglin dari deret baku)

    0,669 = 0,0509x-0,0912

    30

    = 14,93 mg%

    =bx + a

    0,398 = 0,0509x-0,0912

    45

    = 9,61 mg%

    = bx + a

    0,163 = 0,0509x-0,0912
    x

    = 4,99 mg%

    60

    = bx + a

    0,398 = 0,0509x-0,0912
    x

    = 9,61 mg%

    Q
    15

    = 14,93 mg%
    = 14,93 mg/100ml ad 10ml
    = 1,493mg/10ml

    30

    = 9,61 mg%
    = 9,61 mg/100ml ad 10ml
    = 0,961 mg/10ml

    45

    = 4,99 mg%
    = 4,99 mg/100ml ad 10ml
    = 0,499 mg/ml

    60

    = 9,61 mg%
    = 9,61 mg/100ml ad 10ml
    = 0,961 mg/10ml

    t k
    15
    30
    45
    60

    As-Ak
    0,669
    0,398
    0,163
    0,398

    t
    15
    30
    45
    60

    Qkum
    1,493
    2,454
    2,953
    3,914

    Reglin

    C (mg%)
    14,93
    9,61
    4,99
    9,61

    Q
    1,493
    0,961
    0,499
    0,961

    Q Kum
    1,493
    2,454
    2,953
    3,914

    a = 0,763
    b = 0,0517
    r = 0,9929
    ka = 0,0517
    A

    =pxl
    = 20,5 cm x 1,0 cm = 20,50 cm2 = 2050mm2

    PM=

    slope
    0,0517
    =
    =2,52 107 mm/menit
    h
    2050 mm .100

    Log Time
    Y = bx + a ( reglin t vs Qkum)
    0 = 0,0517x + 0,763
    x = 14,758 menit
    x = 15 menit
    KELOMPOK 2 OBAT B (MINIASIN)
    T

    AbsorbansiUji

    15
    30
    45
    60

    0,604
    0,437
    0,287
    0,377

    C (mg%)
    15

    = bx + a

    0,302 = 0,0509x-0,0912

    30

    = 7,72 mg%

    =bx + a

    0,362 = 0,0509x-0,0912
    x

    = 8,88 mg%

    AbsorbansiKontrol
    0,302
    0,075
    0,051
    0,075

    45

    = bx + a

    0,236 = 0,0509x-0,0912

    60

    = 6,43 mg%

    = bx + a

    0,302 = 0,0509x-0,0912
    x

    = 7,72 mg%

    Q
    15

    = 7,72 mg%
    = 7,72 mg/100ml ad 10ml
    = 0,772mg/10ml

    30

    = 8,88 mg%
    = 8,88 mg/100ml ad 10ml
    = 0,888 mg/10ml

    45

    = 6,43 mg%
    = 6,43 mg/100ml ad 10ml
    = 0,643 mg/ml

    60

    = 7,72 mg%
    = 7,72mg/100ml ad 10ml
    = 0,772 mg/10ml

    t k
    15
    30
    45
    60

    As-Ak
    0,302
    0,362
    0,236
    0,302

    t
    15
    30
    45

    Qkum
    0,772
    1,660
    2,303

    C (mg%)
    7,72
    8,88
    6,43
    7,72

    Q
    0,772
    0,888
    0,643
    0,772

    Q Kum
    0,772
    1,660
    2,303
    3,075

    60

    3,075

    Reglin
    a = 0,0645
    b = 0,0503
    r = 0,9982
    ka = 0,0503
    A

    =pxl
    = 1,2 cm x 19,2 cm = 23,04 cm2 = 2304mm2

    PM=

    slope
    0,0503
    =
    =2,18 105 mm/menit
    h
    2304 mm . 100

    Log Time
    y

    = bx + a

    0= 0,0503x + 0,0645
    x

    = -1,282 menit

    = 1,282 menit

    Rata-rata log time = (15 menit + 1,282 menit ) : 2 = 8,141 menit

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