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Biomedical Engineering
Biomedical Engineering
org/biomedical-engineering
second
edition
biomedical
engineering
Explore this rapidly growing field with
research from eight leading biomedical
engineering publications
contents
Introduction
Biomedical Materials
Biofabrication
Nanotechnology
10
Physiological Measurement
12
Physical Biology
14
16
medicalphysicsweb
18
20
21
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biomedical engineering
Biomedical engineering is a rapidly growing discipline covering
the application of engineering principles and materials
technology to healthcare. The field seeks to bridge the gap
between engineering and medicine, combining the design
and problem-solving skills of engineering with medical and
biological sciences. This can include researching, designing
and developing medical therapeutic products and biological
systems, or optimizing/managing the use of clinical equipment
to improve diagnosis, monitoring and therapy for patients.
iopscience.org/biomedical-engineering
Biomedical Materials
Biomedical Materials publishes original
research findings that contribute to our
knowledge of the composition, properties and
performance of materials for tissue engineering
and regenerative medicine applications.
Included within the scope are applications that utilize
biomedical materials in the treatment of the underlying
causes of loss of tissue (e.g. trauma, disease and ageing), in
concert with the role of the material in tissue engineering and
regenerative medicine, namely, a scaffold.
Worldwide visibility
More than 125000 full-text
downloads in 2012
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iopscience.org/bmm
iopscience.org/biomedical-engineering
FEATURED ARTICLE
Injectable perlecan domain 1-hyaluronan microgels potentiate the cartilage repair effect of BMP2 in a
murine model of early osteoarthritis
Padma P Srinivasan, Sarah Y McCoy, Amit K Jha, Weidong Yang, Xinqiao Jia, Mary C Farach-Carson
and Catherine B Kirn-Safran
2012 Biomed. Mater. 7 024109
Abstract
The goal of this study was to use bioengineered injectable microgels to enhance the action of bone
morphogenetic protein 2 (BMP2) and stimulate cartilage matrix repair in a reversible animal model of
osteoarthritis (OA). A module of perlecan (PlnD1) bearing heparan sulfate (HS) chains was covalently
immobilized to hyaluronic acid (HA) microgels for the controlled release of BMP2 in vivo. Articular
cartilage damage was induced in mice using a reversible model of experimental OA and was treated
by intra-articular injection of PlnD1-HA particles with BMP2 bound to HS. Control injections consisted
of BMP2-free PlnD1-HA particles, HA particles, free BMP2 or saline. Knees dissected following these
injections were analyzed using histological, immunostaining and gene expression approaches. Our results
show that knees treated with PlnD1-HA/BMP2 had lesser OA-like damage compared to control knees.
iopscience.org/biomedical-engineering
Biofabrication
Biofabrication focuses on the forefront research
and development of emerging technologies that
employ a range of physical, chemical, biological
and engineering methods to fabricate models,
systems, devices, interfaces and products
oriented for bio-applications using biologically
active or biologically derived components.
Worldwide visibility
545 average downloads per
article in 2012
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decision in just
29 days
iopscience.org/bf
iopscience.org/biomedical-engineering
FEATURED ARTICLE
Development of a valve-based cell printer for the formation of human embryonic stem cell spheroid
aggregates
Alan Faulkner-Jones, Sebastian Greenhough, Jason A King, John Gardner, Aidan Courtney
and Wenmiao Shu
2013 Biofabrication 5 015013
Abstract
In this paper we report on the development of a valve-based cell printer that has been validated to print
highly viable cells in programmable patterns from two different bio-inks with independent control of the
volume of each droplet (with a lower limit of 2 nL or fewer than five cells per droplet). Human ESCs were
used to make spheroids by overprinting two opposing gradients of bio-ink; one of hESCs in medium and the
other of medium alone. The resulting array of uniform sized droplets with a gradient of cell concentrations
was inverted to allow cells to aggregate and form spheroids via gravity. The resulting aggregates have
controllable and repeatable sizes, and consequently they can be made to order for specific applications.
Spheroids with between 5 and 140 dissociated cells resulted in spheroids of 0.250.6 mm diameter.
Nanotechnology
When navigating the tiny intricacies of the human
body, nanoscale materials and structures are an
obvious choice. Nanotechnology has become a
hotbed for top research reports on developments
in biology and medicine that exploit the rare
combinations of useful properties observed in
nanomaterials.
nanotechweb.org
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people who read the latest
in nanotechnology research
every month
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75 days
iopscience.org/nano
iopscience.org/biomedical-engineering
FEATURED ARTICLE
Control of neuronal network organization by chemical surface functionalization of multi-walled carbon
nanotube arrays
Jie Liu, Florence Appaix, Olivier Bibari, Gilles Marchand, Alim-Louis Benabid, Fabien Sauter-Starace
and Michel De Waard
2011 Nanotechnology 22 195101
Abstract
Carbon nanotube substrates are promising candidates for biological applications and devices. Interfacing
of these carbon nanotubes with neurons can be controlled by chemical modifications. In this study, we
investigated how chemical surface functionalization of multi-walled carbon nanotube arrays (MWNT-A)
influences neuronal adhesion and network organization. Functionalization of MWNT-A dramatically
modifies the length of neurite fascicles, cluster inter-connection success rate, and the percentage of
neurites that escape from the clusters. We propose that chemical functionalization represents a method
of choice for developing applications in which neuronal patterning on MWNT-A substrates is required.
iopscience.org/biomedical-engineering
Worldwide visibility
The average number of
downloads per article published
in 2012 was more than 700
3.837
10 iopscience.org/biomedical-engineering
iopscience.org/jne
FEATURED ARTICLE
An implantable wireless neural interface for recording cortical circuit dynamics in moving primates
David A Borton, Ming Yin, Juan Aceros and Arto Nurmikko
2013 J. Neural Eng. 10 026010
Abstract
We have designed and implemented a neural interface microsystem, housed in a compact, subcutaneous
and hermetically sealed titanium enclosure. Device verification and early validation were performed in
both swine and non-human primate freely-moving animal models and showed that the wireless implant
was electrically stable, effective in capturing and delivering broadband neural data, and safe for over
one year of testing. In addition, we have used the multichannel data from these mobile animal models
to demonstrate the ability to decode neural population dynamics associated with motor activity. The
use of this new implantable neural interface technology can provide insight into how to advance human
neuroprostheses beyond the present early clinical trials. Further, such tools enable mobile patient use,
have the potential for wider diagnosis of neurological conditions and will advance brain research.
iopscience.org/biomedical-engineering
11
Physiological Measurement
A journal for sensors, instrumentation and
systems in physiology and medicine,
Physiological Measurement covers the
quantitative assessment and visualization
of physiological function in clinical
research and practice.
Worldwide visibility
More than 120000 article
downloads in 2012
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first decision in just
45 days
iopscience.org/pmea
Published in partnership with:
Institute of Physics and
Engineering in Medicine
12 iopscience.org/biomedical-engineering
FEATURED ARTICLE
Dynamic time warping and machine learning for signal quality assessment of pulsatile signals
Q Li and G D Clifford
2012 Physiol. Meas. 33 1491
Abstract
In this work, we describe a beat-by-beat method for assessing the clinical utility of pulsatile waveforms,
primarily recorded from cardiovascular blood volume or pressure changes, concentrating on the
photoplethysmogram (PPG). Physiological blood flow is nonstationary, with pulses changing in height,
width and morphology due to changes in heart rate, cardiac output, sensor type and hardware or software
pre-processing requirements. Moreover, considerable inter-individual and sensor-location variability
exists. Simple template matching methods are therefore inappropriate, and a patient-specific adaptive
initialization is therefore required.
iopscience.org/biomedical-engineering
13
Physical Biology
Physical Biology focuses on the interdisciplinary
field where physicists and engineers are
working with biologists to gain new insights into
biological systems at all scales of space and
time, and all levels of complexity. Research
areas covered include physical aspects of
disease, developmental processes and
neuronal dynamics.
Worldwide visibility
More than 95000 article
downloads in 2012
Fast publication
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first decision in just
36 days
14 iopscience.org/biomedical-engineering
iopscience.org/pb
FEATURED ARTICLE
The compositional and evolutionary logic of metabolism
Rogier Braakman and Eric Smith
2013 Phys. Biol. 10 011001
Abstract
Metabolism is built on a foundation of organic chemistry, and employs structures and interactions at many
scales. Despite these sources of complexity, metabolism also displays striking and robust regularities
in the forms of modularity and hierarchy, which may be described compactly in terms of relatively few
principles of composition. These regularities render metabolic architecture comprehensible as a system,
and also suggests the order in which layers of that system came into existence. In addition metabolism also
serves as a foundational layer in other hierarchies, up to at least the levels of cellular integration including
bioenergetics and molecular replication, and trophic ecology. The recapitulation of patterns first seen
in metabolism, in these higher levels, motivates us to interpret metabolism as a source of causation or
constraint on many forms of organization in the biosphere. Many of the forms of modularity and hierarchy
exhibited by metabolism are readily interpreted as stages in the emergence of catalytic control by living
systems over organic chemistry, sometimes recapitulating or incorporating geochemical mechanisms.
iopscience.org/biomedical-engineering
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Worldwide visibility
More than 650000 article
downloads in 2012
Fast publication
Average receipt to
first decision in just
50 days
Published in partnership with:
Institute of Physics and
Engineering in Medicine
16 iopscience.org/biomedical-engineering
iopscience.org/pmb
FEATURED ARTICLE
Navigators for motion detection during real-time MRI-guided radiotherapy
Mette K Stam, Sjoerd P M Crijns, Bernard A Zonnenberg, Maurits M Barendrecht, Marco van Vulpen,
Jan J W Lagendijk and Bas W Raaymakers
2012 Phys. Med. Biol. 57 6797
Abstract
An MRI-linac system provides direct MRI feedback and with that the possibility of adapting radiation
treatments to the actual tumour position. This paper addresses the use of fast 1D MRI, pencil-beam
navigators, for this feedback. The accuracy of using navigators was determined on a moving phantom.
The possibility of organ tracking and breath-hold monitoring based on navigator guidance was shown for
the kidney. Navigators are accurate within 0.5 mm and the analysis has a minimal time lag smaller than
30ms as shown for the phantom measurements. The correlation of 2D kidney images and navigators
shows the possibility of complete organ tracking.
iopscience.org/biomedical-engineering
17
medicalphysicsweb
medicalphysicsweb provides in-depth analysis and incisive
commentary on the fundamental research, emerging
technologies and clinical applications that underpin the core
disciplines of medical physics and engineering.
The website covers, in a highly accessible form, some of the most
interesting and timely research published in the fields of medical physics
and engineering. A number of the stories feature new research from the
prestigious journal Physics in Medicine & Biology, covering everything
from the latest technologies for delivering state-of-the-art radiation
therapy to the latest developments in PET detectors.
Other IOP Publishing journals covered include Physiological
Measurement, a broad-based biomedical engineering journal with
an emphasis on the development of new methods of measurement
and their validation, and Biofabrication, a tissue-engineering journal
focusing on using cells, proteins and biomaterials to manufacture
advanced biological systems and medical therapeutic products.
medicalphysicsweb.org
18 iopscience.org/biomedical-engineering
iopscience.org/biomedical-engineering
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Additional content
Bioinspiration & Biomimetics
Bioinspiration & Biomimetics publishes research that applies principles
abstracted from natural systems to engineering and technological design
and applications, including both the design and practical applications of
biomimetics or bioinspired devices and systems.
The journal has grown significantly since its launch in 2006 and has become
well respected in its field. It is included in MEDLINE and Thomson Reuters
(ISI) Web of Knowledge, with an Impact Factor in 2011 of 1.952.
iopscience.org/biomedical-engineering
21
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Hydrogel
Analytical
Models
Compression
Torsion
Modular
Design
1 to 3 axes
Tension
Force Range
Cartilage
1.5 to
100 N
Indentation
Force
Resolution
Automatic
Mapping
Fits
Mechanical
Incubator Stimulation
to 75 N
Travel Range
50 to
250 mm
Shear
www.biomomentum.com
info@biomomentum.com
quantum
information
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graphene
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semiconductors
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quantum-information
iopscience.org/metamaterials
Materials science:
from research to
technology
plasma
physics
metamaterials
iopscience.org/materials-science
A showcase of cutting-edge
research taken from selected
journals and Physics World.
iopscience.org/plasma-physics
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plasma-physics
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materials-science
iopscience.org/
metamaterials