Professional Documents
Culture Documents
Kasiske 1998
Kasiske 1998
L. KASISKE,*
*Dit,ision
of Nephrology,
Minnesota;
Abstract.
This
inequities
in the
eric
renal
and
cohort
Factors
Waiting
Department
study
current
whether
for
listing
patients
univariate
and
using
analyses
to identify
factors
before
initiation
of dialysis.
LONDON,t
of Medicine,
of Research,
investigates
system
transplantation,
WENDY
Department
associated
It includes
United
there
for
Influencing
List
are
cadav-
Network
ance
Sharing,
full-time
time);
receiving
(OR
for kidney-pancreas
center
ysis
sis
initiation)
pendent
cluded:
at the
before
males);
dialysis
age
b7
respectively,
was
and
respectively,
The United
States
organs
OPTN
is currently
Sharing
(UNOS).
part in organ
for allocating
exceeded
times
the
have
are
more
equal
(2).
to
UNOS
cadaveric
and
and efficient.
who
the
need
the
system
time,
likely
for
so that
allocating
individuals
to receive
It is understandable
a kidney,
that
once
pin
County
to Dr.
Medical
Bertram
Center,
L. Kasiske.
701
Park
Avenue,
Department
Minneapolis,
made that
physicians
possible,
racial
inequities
directed
at patients
uniform
help
with
fewer
those
counterparts
dialysis.
listing
to be
These
results
the
current
in
in the
and
United
providers,
criteria
to reduce
and
ethnic
and
transplantation
anal-
and
their
renal
may
transplantation
will want
to begin
advantage
as
for cadaveric
these
inequities.
waiting
more
have
waited
regard
all other
factors
there
a decision
has
Henne55415.
is usually
before
before
indicator
possible
who
register
care
no
dialysis
renal
may
be advantageous
who
after
transplanta-
to determine
did
in
or did
patients
in the allocation
with
whether
not
who
initiating
Thus,
practical
initiation
cadaveric
differences
inequities
who
dialysis,
kidney.
offers
we sought
in patients
those
and
patients
for
dialysis
accrual,
Major
to health
Materials
All
time
potential
be an
main-
theoretically
initiating
a cadaveric
usually
listing
before
differences
versus
indicate
access
of early
dialysis.
may
before
waiting
time accrual.
before
maintenance
listing
were
it may
initiating
dialysis
with
transplantation
to waiting
Indeed,
before
a transplant
patients
and
as soon
as
not
before
Because
time.
before
to receive
advantage
other than
We used registration
tion.
waiting
for transplantation
Registering
patients
registering
is an option,
both
registration
to occur
accruing
to register
dialysis.
allow
awards
MN
transplantation,
than
before
mandated
the
transplant
that
remediable
efforts
tation
has
is now
of Medicine,
transplantation,
educated,
likely
for
in recent
kidneys
who
be
and thereby
obviate
However,
given the
Received
February
3, 1998. Accepted
May 9, 1998.
The statements
contained
in this report are solely those of the authors and do
not necessarily
reflect the views of the United Network
for Organ
Sharing.
Correspondence
been
their
as an
point
may
registration
as recently
tenance
take
transplant
time
there
organ
well
pay);
listed
kidney
(OR
=
1.22,
bias for general
a previous
It is concluded
transplantation
a system
that is
As a result,
waiting
Education
Organ
who
However,
a kidney
of organs.
median
States.
programs,
has established
transplantation
had
are less
renal
for
allocate
others
for
who
less
insur-
other
refer-
for
up of transplant
for
system
administer
Network
patients,
supply
and
for waiting
longer
United
is made
workers,
available
being
contract
the
equitable
increased,
than 2 yr (1).
The
UNOS
points
The
by
listed
with
volume
>400
To remove
possible
referral
resources
reference:
private
reference;
not on insulin):
1 .43, reference:
listed for
and
those
financial
and
reference:
to patients
results.
suggest
Procurement
and
similar
minorities,
well
care
limited
1.80,
race,
0.55,
to health
was
1.14,
black
and
to retrieve
of patients
in
attended
1 1 8, and
degree);
0.59,
the Organ
transplantation.
kidneys
for
and
(OR
(OPTN)
UNOS
to be both
school
0.47,
ini.e.,
than
1.91
transplant
created
care
the number
(OR
Network
held
health
designed
(OR
transplantation.
individual
in females
Congress
Transplantation
for
high
Asian/other
0.001)
male,
access
found
Inde-
0 to 8 yr education,
degree
(OR = 0.78,
reference:
and
examined.
likely
prior
>55);
or postdialy-
dialysis
(P <
1.14, reference:
18 to 55
age
(pre-
were
more
no prior transplant);
and received
a college
Hispanic,
years
14%
age
reference:
reference:
college,
and
of registration
predictors
of listing
before
female
(odds ratio [OR] =
listing
I .37,
time
status
1.98,
Medicare
respectively,
(OR
and
dialysis
Virginia.
(OR
with
1 .29,
only);
listed
at a center
reference:
volume
<400).
predicting
Richmond,
1 .24,
the kidney
and kidney-pancreas
waiting
lists between
April 1,
1994, and June 30, 1996 (n
41,596)
from all 238 United
Network
for Organ
Sharing
renal transplant
centers.
Patient
factors
Minneapolis,
employment
and
insulin
Center,
payment
0.35
Placement
D. ELLISONt
Organ
full
(OR
MARY
Medical
white);
than
Early
County
for
ence:
less
multivariate
and
Hennepin
Soc
dialysis
system,
register
register
could
and/or
in
in general.
Methods
registered
with
UNOS
on
the
national
OPTN
1 , I 994,
and
June 30, 1996, were included in this analysis if their dialysis status at
the time of registration
was known (95.4% of all registrations).
Data
kidney
and
kidney-pancreas
waiting
lists
between
April
J Am Soc Nephrol
were
using
from
the
9: 2142-2147,
238 centers.
The
UNOS
Transplant
included
the
kidney
transplant,
following
400
variables:
period
versus
projected
a center
and
the
across
univariate
(I 994,
out both
we
responses
logistic
we
used
registration
after
dependent
or
this
kidney
status
at registration,
1996).
performed
carried
out
we
was that
registration
individuals
listing
in the final
logistic
per patient.
selected
after
versus
care.
subgroup
of patients
who
analysis
there
one
that
initiating
to health
regression
When
possibility
in access
that
6.12.
including
patients
again.
The
could
than
and
was
one
excluded
differences
dialysis
did
this
had
a previous
by
center
included
than
one
the
others.
in patients
who
may reflect
We
bias
The former
Therefore,
that
more
general
assistance,
or unable
out
only
registraWe
also
registered
differences
separately
analyzing
the
transplant,
reasoning
that
predialysis
versus
those
not be explained
by other
that could
variables.
Multivariate
were
dialysis.
were
Analysis
a total
multiple
of 41 ,596
listings.
A number
registrations
Of all registrants,
of characteristics
of which
1 8.4%
were
different
57.7%
yet on dialysis
prior
transplant.
often
white.
only
were younger
They
were
Patients
were
and
better
not on dialysis
male
were
(Table
1 1.9%
maintenance
defined
of daily
with
been
with
living
a slight
listed
as:
living
with-
for those
tendency
for
rather
than
in 1996
dialysis
91%,
and
listed
before
times
those
18 to 55
dialysis.
as likely.
47,
The
Individuals
ment status
dialysis
more
had a
more
of registration
greater
were
before
under-
for females
com-
with individuals
17 yr or younger
who
were
14%
with
years
more
a prior
likely
to be
transplant
of schooling
as likely
were
with
to patients
primary
source
likely,
whereas
likely
volume
to be listed
before
center
were 22%
Patients
istered
those
were
before
obtained
was
prior
kidney
cant
predictors
(Table
whole
3),
only
one
there
of patients
were
population.
similar
Of
(logistic)
those
5944).
to
those
note,
patients
before
with
a greater
likelihood
with
a reduced
likelihood
of patients
was analyzed
(Table
absence
of age as an independent
reglikely
due
found
used
registrations
same.
When
who
dialysis
In general,
had
or
the
had
signifi-
was
reinitiated
to a much
the independent
in part
in the
analysis
of
the
0 to 8 yr of education
of listing
when
before
the larger
2). It is possible
predictor
in this
a surrogate
results
was
statistically
are
however,
compared
became
at a high-
regression
fewer
predictors
=
as
more
predialysis.
per patient
of whether
were the
were
correlated
8 yr of schooling
34%
21%
2).
listed
fewer
(n
time.
whose
only
were
Patients
listed
to be listed
likely
regardless
the results
to only
size
full
those
were
registration
restricted
although
than
insurance
(Table
transplant,
sample
Medicare
multivariate
when
the
dialysis.
required
insulin,
and patients
transplant
were also more
dialysis
identical,
less
dialysis.
with diabetes
who
for a kidney-pancreas
before
sources,
private
more
had,
or whose
employto be listed before
payment
was
with
time,
likely
working
other
of payment
a patient
to be listed
full
more
those
with
those
than 3
as whites
compared
Compared
correlates
not
yr old
Individuals
between
I). Those
14%
smaller
at the time of
male, of those
were
with males
(Table
2). Compared
more than 55 yr old at listing,
those
not yet on
more likely
to have
educated
and were
at the time
also
Analysis
analysis
Results
Univariate
There
were
of daily
activities
to have
dialysis
to require
They
status
activities
on dialysis,
the frequency
if diabetic,
Functional
assistance.
to be listed
Virtually
patents
to have
of payment.
to be listed at a
at registration.
on dialysis.
performs
to perform
these patients
likely had fewer
barriers
to health
care, at least with
respect
to transplantation.
Finally,
we carried
out logistic
regression
to
determine
the extent to which there were center-specific
differences
in
with which
and,
not
on dialysis.
model.
version
in more
those
likely
source
was
and those
1994 or 1995.
charac-
listings
more
more likely
on dialysis
to be diabetic
with
limitations,
pared
were
multiple
likely
no activity
I) or
that including
more
compared
were
primary
dialysis
predictors).
and registered
and
as a projected
2143
transplant
than
across
categothose
not on
grouped
patients
as
Model
building
was
to be working
Transplantation
going
kept
for Kidney
yet on dialysis
were
center
than patients
were
insulin
software,
They
Listing
as the
or center
(the
likely
insurance
anal-
out a second
the
before
(0)
from individuals
who registered
only once.
more weight
than the latter in the analysis.
randomly
more
private
those
SAS/STAT
the results
it is possible
registration
addressed
0.05)
<
using
we carried
patient
variables
manner,
(P
a transplant,
were different
would
receive
the
the
across
dialysis
dialysis
of this approach
regarding
which
the results
and
in
dialysis
the multivariate
before
on maintenance
stepwise
one. However,
For
For the
differences
after
We first analyzed
advantage
decisions
test
listing
as the independent
significant
received
to
analyses.
versus
variable.
with
response),
in a forward
was
test
before
placed
the categories
statistically
Analysis
for each
above
registration
18 to 40,
and multivariate
regression
(the
described
In most cases,
tion,
1995,
used
being
variable
teristics
one
during
were
Patients
not
high-volume
race/ethnicity,
of registrations
functional
registering
ysis,
tered,
of previous
achieved,
diabetes/insulin-dependent,
univariate
of patients
all categorical
who
who
number
registration,
analysis,
proportions
were
history
collected
(3). We
Analyses
We carried
UNOS
17,
age,
level
was
Form
payment
source,
registered
at a highwith more than 400 registrations,
where
all centers),
of listing
Statistical
gender,
median
kidney-pancreas
the year
in the database
Registration
education
, at
is approximately
time
information
Candidate
highest
employment
status,
volume
center (i.e.
Early
1998
for
younger
dialysis,
population
that in the
model,
0 to
age.
2 144
Table
Journal
of the American
1. Characteristics
Society
of registrants
who
were
pre-
versus
Overall
(%)
P Value
57.7
59.3
<0.001
yr
3.8
2.7
Male
Age
18 to 40 yr
39.4
36.1
41 to 55 yr
37.5
35.9
>55
yr
14.3
20.2
not reported
Previous
transplant
4.9
5.1
17.6
14.4
Highest
none
education
attended
college
associate
or bachelor
post-college
degree
degree
unknown
Race/ethnicity
0.9
1.1
3.8
27.6
5.8
34.6
20. 1
1 8. 1
14.8
10.5
6.9
4.0
25.9
25.9
white
73.9
56.9
black
13.7
26.1
Hispanic
8.4
1 1.8
Asian
2.7
3.4
other
1.4
1.9
Employment
full time
not
not
53.4
time
working
working
unable
by choice
due to disease
to find
not working
retired
employment
Source
<0.001
<0.001
bevel
Oto8yr
9 to 12 yr
part
9: 2142-2147,
postdiabysis
Predialysis
(%)
Characteristic
l7
J Am Soc Nephrol
of Nephrology
work
for
unknown
status
unknown
reasons
<0.001
<0.001
34.5
6.5
8.2
2.6
19.2
3.8
31.7
0.6
0.8
2.8
4.7
10.0
4.2
7.7
9.0
<0.001
of payment
Medicare
Medicaid
23.2
7.3
other government
private
insurance
65.2
2.2
self
donation
other
or free
care
High-volume
center
50.1
7.6
2.0
<0.001
38.9
1.0
0.8
0.2
0.9
0.2
0.5
40.6
34.3
Diabetic
42.1
36.3
<0.001
Requiring
insulin
Kidney-pancreas
89.6
12.7
82.3
7.1
<0.001
<0.001
8 1 .7
81.9
8.8
0.6
10.4
0.7
9.0
7.0
Functional
no activity
listing
<0.001
status
limits
activities
with assistance
needs total assistance
not applicable/unknown
Listing
in (year)
1994
30.8
31.7
1995
45.6
45.6
1996
23.6
22.7
>0.05
<0.05
1998
J Am Soc Nephrol
Table
9:
The
2.
2142-2147,
odds
of being
initiating
Early
1998
placed
maintenance
on the United
dialysis
for
Network
41,596
Reference
waiting
Transplantation
list before
2145
after
versus
Group
Odds
Ratio
P Value
0.0001
1.136
Age
>55
yr
1.914
0.0001
Age
>55
yr
1.142
0.0001
First
transplant
1 .798
0.0001
First
transplant
3.250
0.0001
0 to 8 yr of schooling
High
school
degree
0.775
0.0004
Attended
High
school
degree
1 176
0.0001
degree
1 .363
0.0001
Age
l7
yr
Age
18 to 55
Prior
transplant
Prior
transplant
yr
unknown
college
Received
a college
degree
High
school
Black
White
0.465
0.0001
Hispanic
White
0.588
0.0001
White
0.548
0.0001
0.0001
0.0001
0.0001
Asian
or other
Full-time
employment
Employment
Medicare
Private
unknown
insurance
From
high-volume
Receiving
centerb
Less
than
full-time
1 .988
Less
than
full-time
1 .496
Other
pay
Other
pay
Low-volume
Not
insulin
Kidney-pancreas
on
0.343
1 .209
1 .222
centerb
0.0001
0.0001
insulin
1.283
0.0001
only
1 .426
0.0001
Kidney
Includes
patients
listed at more than one center.
High volume
is a center
with more than 400 listings.
Table
The odds
for Organ
3.
versus
of being
Sharing
after
prior
graft
renal
placed
(UNOS)
failure
frequently
on the United
Network
waiting
list before
5944
for
patients
only
with
than
0 to 8 yr of
High
schooling
Group
school
Odds .
P Value
1 .384
0.0 153
Ratio
degree
Black
White
0.715
0.0001
Hispanic
White
0.736
0.0048
0.626
0.0114
1.834
1.397
0.0001
0.0012
Otherpay
Other
pay
0.751
1 .579
Non-diabetic
1 .740
0.0135
0.0002
0.0001
Asian
or other
Full-time
Employment
White
Less
Less
employment
unknown
Medicare
Private
insurance
Diabetic
Excludes
multiple
these
suggested
Reference
than
than
full-time
full-time
of the
Superimposing
transplantr
Variable
expected.
12 (5%)
that
centers
(UNOS)
Male
Female
Sharing
for Kidney
registrationsa
Variable
for Organ
Listing
that
there
By chance,
to have
centers
on a map
was
differed
we would
centers
a random
from
the
Renal
Function
at the
Patients
Transplanted
have
entered
into
of the
geographical
norm
(not
expected
the
model.
United
States
distribution
of
shown).
Time of Transplantation
before
Dialysis
for
3172
data
(age,
gender,
UNOS
Kidney
tion of creatinine
(4).
body
weight,
Transplant
clearance
Estimated
creatinine
listed
before
dialysis
(mean
at the
SD)
and
serum
creatinine)
from
Registration
Form to allow
using the Cockcroft-Gault
clearance
in
initiation
time
this
was
subset
16.7
the
estimaformula
of
patients
10.2
mb/mm
of transplantation.
listings.
Discussion
Center-Specific
Differences
at
transplant
(after
into
centers
patients
an
centers.
or
for
the model
(36.
in these
less
age,
model
found
indicator
If registrants
more
adjusting
enter
regression
variables
listing)
significantly
86
in a logistic
independent
status
before
In this
of listing
Dialysis
waiting
Initiation
We included
other
in Listing
to correlate
for
from
a particular
likely
gender,
to
centers
entered
were
be
into
listed
each
then
before
that
center
predictor.
the
model,
before
of
center
listed
etc.),
with
with
variable
as an independent
1 %)
(along
the
dialysis
the
238
were
dialysis
would
Surprisingly,
suggesting
dialysis
more
that
or less
tion
study,
could
list earlier
of patients
for
were
prediabysis
at the time
of placement
on the
of renal
already
disease
on dialysis.
than
of
being
on dialysis
subset
of patients,
reasons.
these
was
were
with
that
renal
clearance
transplanted
this
assumption.
function
that
symptoms,
and not for
of creatinine
who
compatible
it is likely
to decline
with time)
placed
on the waiting
Estimates
patients
registra-
We assumed
placed
on dialysis
because
of signs,
indicators
of end-stage
renal disease,
nonmedical
a subset
in the course
who
patients
were
and laboratory
other,
we assumed
that being
be used as an indicator
(which
before
In this
tends
2146
Journal
when
it was
not
be
of the American
measured.
Although
representative
before
of
dialysis,
Society
all
this
patients
it nevertheless
subset
had better
renal
function,
on
in their
course
renal
disease
the
and were
as possible,
UNOS
may
point
wait
likely
patient
as possible
many
American
Society
centers,
least
patients
who
waiting
time
listing
criteria,
study,
a logistic
30,
often
influenced
listing.
educated,
white,
working
coverage
were
with
patients
ethnic
others,
not
may
be
alter
nomically
before
effects
who
care
before
who
relisted
before
had
likely
rest
both
have
suboptimal
to keep
concerns
are
not
barriers
center
coverage.
Indeed,
coverage
for
were
socioeconomic
even
when
there
still
if they
and
There
do not
have
to
of patients
delayed
Even
inequities
ties
to be
employed
ized
and
care
the
is
vast
not
are
to under-
may
services.
is adequate
be more
the transplant
(even
when
overcoming
simply
these
have
influence
health
insurance
coverage
to
of
in this
listing
found
care
race
some
of
steps
system,
major
can
the
very
organ
appear
and
and
allocation
threatens
of altruistic
there
do
trans-
are
of organ
inequity
system
reasons,
there
donato be
these
inequi-
Secretary
things,
these
AM,
registry:
rules
of Health
governing
mandate
criteria
on the
listing
Department
set of rules
listing
bevel
of
that
for
UNOS
could
be
held
criteria
for renal
list.
be
an
current
transplanUNOS
and
to require
filtration
soon.
important
first
disparities
that
The
a consensus
glomerular
implemented
the
UNOS
determining
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Physicians
estimated
likely
of the
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a new
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appear
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had
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However,
that
issued
will
allocation
concerns
study
waiting
some
to fail
due
socioeconomic
a matter
of patients
Others
likely
center,
shown
until
of Transplant
correcting
1.
bevel
transplant
overcome
standardized
can
a threshold
References
who
likely
to
on standardized
Patients
be less
the
Society
caregivers.
majority
factors
uniform,
organ
been
allocation
other
patients
our
payment
However,
Among
(Table
3).
in early listing
coverage
with
Services
listing
and education
cadaveric
addressed.
4, 1998,
before
of steps
(9).
perception
tation
on January
National
Institutes
rate
status,
the
at large.
Human
conference
pa-
number
that
socioeconomic
difficult
On April
American
may
disadvantaged
Identificais influ-
income
organ
and
socioeconomic
factors.
for renal transplantation
have
to ensure
be
in other
others,
transworkers
patients
than
of
to be influ-
on
gender
delay
care
to a growing
employment
placed
in the
coverage
discrepancies
may
gender,
the
should
reaching
Indeed,
likely
white,
is fair.
when
i.e.,
more
were
gender,
and
candidates
be
have
seem
foundation
upon which
our
tion is built.
For whatever
establish
early,
reason.
be taken
OPTN.
socioeco-
that
transplantation
in society
should
of listing
early, and, as a result,
may not
for themselves.
In addition,
patients
who
transplant
and
patients
may
and
centers
transplant
initiation
earlier
listing.
listed
patients
cost
health
these
list
that
suggests
well-founded).
to
early
likely
be
less
to differences
between
on
or
had
that
the analysis
appointments
about
(compared
is due
may
that
insurance
and
plantation
also
socioeconomically
be added
racial
that
who
health
sooner
to renal
a lower
of the
changes
better
of a racial
with
Many
could
manage
listed
can now
and
patients
that
dialysis.
been
age,
patients
dialfactors
better
However,
insurance
initial
did
(before
by race,
for
present
effect
younger,
centers
it less
in general,
disadvantaged
In the
center
time,
this
factors
had better
insurance
for socioeconomic
with
for
on standardized
a transplant
a prior
socioeconomically
race,
dialysis.
dialysis
full-time,
and
The reasons
list,
list
points
received
to the transplant
patients
Having
dialysis
by
individuals
had previously
referral
that
make
It is possible
nephrobogists
before
(7).
for differences
that
to health
to
This
before
road
enced
had
full
served
of these
disadvantaged
access
a recent
listing
the
trans-
educated,
than
adjusting
reasons
dialysis.
good
less
well
Early
along
center
were
before
less
It is unlikely
the
several
wish
In
their
sooner
and
listed
of patients
because
to be listed
to be
likely
that
for
who
time,
older,
working
populations
than
full
often
coverage).
in the
tients
and socioeconomic
Patients
were
minority,
insurance
did
more
who
the more
(6).
unconsciously,
some
in populations
and
it is possible
or
allow
it less
may
waiting
adherence
consciously,
that
common
addition,
poll of UNOS
patients
that race
In
make
centers.
found
early
ways
as
is more
to care
which
medical
enced by race,
tion of potential
MD).
testing
listed
other
study
that
the
Bethesda,
may
total
patients
to accumulate
model
centers
than
present
Listing
possible.
on
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Soc
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well
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The
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socioeconomically
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January
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ysis)
placed
(presented
points
Physicians
of 149 respondents
is medically
on the waiting
soon.
as
Medical
are
plantation.
adds
soon
these
with
to centers
as
that
earlier
the number
advantageous
list
listed
determine
greater
of Transplant
sometimes)
indeed
helps
patients
25%
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time
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is also
as
(at
The
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may
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