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Analgesik Opioid

Act centrally
Addiction, dependence, tolerance
Schedule II/III controlled substances
Notable adverse effects: sedation, respiratory
depression, constipation
No anti-inflammatory effect
No ceiling effect

Analgesik Non-opioid
Act peripherally
Not habit-forming
Not controlled drugs
Notable adverse effects: gastric irritation,
bleeding problems, renal toxicity
Anti-inflammatory effect
Ceiling effect - increase in dose does not
increase analgesia but increases side effects

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