1.

2.

Sodium bicarbonate

Sodium bicarbonate

Capsules (hard gelatin)

500

Tablets

300 mg(3.57

mg

mEq/tab)

(5.95 mEq, 137 mg of sodium, 6

7.5% Sodium bicarbonate inj

mmol)

50 ml.(44.6 mEq)

Size: 148.5 x 210 mm

3.

(Compliance)

4.

5.(Phar

: Alkalinizing agent,

: Alkalinizing agent,

macology)

Electrolyte supplement.

Electrolyte supplement.

: Sodium

: Sodium

bicarbonate

bicarbonate

Bicarbonate ion

Bicarbonate ion

Neutralize hydrogen ion

Neutralize hydrogen ion

PH

PH

6.

1.Metabolic acidosis

1.Metabolic acidosis

2.Chronic renal failure

2.Chronic renal failure

3.Renal tubular acidosis

3.Renal tubular acidosis

4.Urine Alkalinization

4.Urine Alkalinization

5.Antacid, Indigestion :

5.Antacid

7.

: Alkalosis,

: Alkalosis,

Hypernatremia, severe Pulmonary

Hypernatremia, severe

edema, Hypocalemia

Pulmonary edema, Hypocalemia

1. CSF
Intracranial hemorrhage
2.

1. CSF
Intracranial hemorrhage
2.

3.
2
hypernatremia

8.Pharmacokinetic

Volume of distribution

Onset of action : Oral: Rapid

I.V.:
15 minutes
Duration: Oral : 8-10 minutes
I.V. : 1-2 hr
Absorbtion : Oral: Well
absorbed
Excretion : Urine(< 1 %)
:

9.

-Metabolic acidosis : =

-Metabolic acidosis :

0.3 X weight(kg) X base

= 0.3 X weight(kg) X base

deficit(mEq/L) administer dose

deficit(mEq/L) administer

initially.then remaining dose

dose initially.then remaining

over the next 24 hr.

dose over the next 24 hr.

-Chronic renal failure :

-Chronic renal failure :

: 1-3 mEq/kg/day

: 1-3 mEq/kg/day

: 20-36 mEq/day in

: 20-36 mEq/day in

divided doses,

divided doses,

18-20 mEq/L

18-20 mEq/L

-Renal tubular acidosis :

-Renal tubular acidosis :

: 2-3 mEq/kg/day

: 2-3 mEq/kg/day

: 0.5 2 mEq/kg/day in

: 0.5 2 mEq/kg/day in

4-5 divided doses

4-5 divided doses

-Urine Alkalinization :

-Urine Alkalinization :

: 1 10 mEq/kg/day

: 1 10 mEq/kg/day

4-6 ;

4-6 ;

pH

pH

: 48 mEq : 48 mEq
12-24 mEq 4 ;

12-24 mEq 4

pH

pH

200 mEq

200 mEq

60 100

60

mEq 60 -

100 mEq

-Indigestion :

60 -

Usual dose : 1-5 g(2-10

capsules)

-Antacid : 325 mg 2 g 1-4

times/day

Maximum dose : 5 g(10

capsules)
- Antacid :325 -2 g to 1-4 times
per day

Increased Effect :

Increased Effect :

amphetamines, ephedrine,

amphetamines, ephedrine,

pseudoephedrine, flecainide,

pseudoephedrine, flecainide,

quinidine, and quinine due to

quinidine, and quinine due to

urinary alkalinization.

urinary alkalinization.

Decreased Effect :

Decreased Effect :

Lithium, chlorpropamide, and

Lithium, chlorpropamide, and

salicylates due to urinary

salicylates due to urinary

alkalinization.

alkalinization.

11.

Muscle weakness and cramps,

Hypernatemia, Hyperosmolarity,

stomach pain, feeling bloated,

Hypocalcemia, Hypokalemia,

belching, high blood pressure

Metabolic alkalosis, Pulmonary

and water retention because the

edema

10.

capsules contain a lot of sodium

12.Pregnancy
Category

Categoly : C

Categoly : C

Lactation: Enter breast milk/

Lactation: Enter breast milk/

Compatible
13.

(Clinical

Compatible

Efficacy)
14./
15./

0.5
Focus Pharmaceuticals Ltd

.
16.

Leaflet information from focus

Drun Information handbook

Pharmaceuticals Ltd

17 Edition 2008-2009

17. .

18.

th