Total quality management (TQM) is an extensively applied system for increasing
organizational performance around the globe. The literature review explores areas of research in this domain of quality operations management, mainly in the area of empirical examining of TQM implementation with effectiveness. The purpose of this study was to examine the total quality management practices and operational performance of manufacturing companies existing in Karachi in order to establish the relationships among these practices, and firm performance. We used sample of 120 executives and managers of manufacturing organizations of Karachi. The Factor analysis, reliability test, regression analysis were conducted for evaluating the practice and performance measures. Our study reveals that the relationship between TQM practice (i.e. leadership, customer focus and strategic planning) and organizational performance is significant. All of the categories of TQM practice were particularly strong predictors of organizational performance. Finding indicates that organizational performance has moderately high correlation with TQM practices along with significant impact Keywords: Organizational Performance; Quality; Leadership, Customer Focus, Strategic Planning Empirical research.